A versatile mitochondria isolation- and analysis-pipeline generates 3D nano-topographies and mechano-physical surface maps of single organelles

Autor: Joshi S, Ciacchi Lc, Manfred Radmacher, Iris Finkemeier, Palovaara J, Peter A, Heinkow P, Kirstein J, Jürgen Eirich, Kubitschke M, Schweser O, Madduri Mk, Maedler K, Mathew Aj, Masseck Oa, Ellinghaus H, Rita Groß-Hardt, Hater F, Callenius H

Living eukaryotic cells typically contain large quantities of highly dynamic mitochondria, which sustain the cells’ energy and redox homeostasis. Growing evidence suggests that mitochondria can functionally differ among but also within cells. The e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d0913168849f9313dbeb26a662389901
https://doi.org/10.1101/2021.10.31.466655

Inhibition of PHLPP1/2 phosphatases rescues pancreatic β-cells in diabetes.

Autor: Lupse B; Centre for Biomolecular Interactions Bremen, University of Bremen, 28359 Bremen, Germany., Annamalai K; Centre for Biomolecular Interactions Bremen, University of Bremen, 28359 Bremen, Germany., Ibrahim H; Centre for Biomolecular Interactions Bremen, University of Bremen, 28359 Bremen, Germany., Kaur S; Centre for Biomolecular Interactions Bremen, University of Bremen, 28359 Bremen, Germany., Geravandi S; Centre for Biomolecular Interactions Bremen, University of Bremen, 28359 Bremen, Germany., Sarma B; Centre for Biomolecular Interactions Bremen, University of Bremen, 28359 Bremen, Germany., Pal A; Centre for Biomolecular Interactions Bremen, University of Bremen, 28359 Bremen, Germany., Awal S; Centre for Biomolecular Interactions Bremen, University of Bremen, 28359 Bremen, Germany., Joshi A; Centre for Biomolecular Interactions Bremen, University of Bremen, 28359 Bremen, Germany., Rafizadeh S; Centre for Biomolecular Interactions Bremen, University of Bremen, 28359 Bremen, Germany., Madduri MK; Centre for Biomolecular Interactions Bremen, University of Bremen, 28359 Bremen, Germany., Khazaei M; Centre for Biomolecular Interactions Bremen, University of Bremen, 28359 Bremen, Germany., Liu H; Centre for Biomolecular Interactions Bremen, University of Bremen, 28359 Bremen, Germany., Yuan T; Centre for Biomolecular Interactions Bremen, University of Bremen, 28359 Bremen, Germany., He W; Centre for Biomolecular Interactions Bremen, University of Bremen, 28359 Bremen, Germany., Gorrepati KDD; Centre for Biomolecular Interactions Bremen, University of Bremen, 28359 Bremen, Germany., Azizi Z; Centre for Biomolecular Interactions Bremen, University of Bremen, 28359 Bremen, Germany; Department of Molecular Medicine, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran 1449614535, Iran., Qi Q; Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA., Ye K; Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA., Oberholzer J; Charles O. Strickler Transplant Center, University of Virginia Medical Center, Charlottesville, VA 22903, USA., Maedler K; Centre for Biomolecular Interactions Bremen, University of Bremen, 28359 Bremen, Germany. Electronic address: kmaedler@uni-bremen.de., Ardestani A; Centre for Biomolecular Interactions Bremen, University of Bremen, 28359 Bremen, Germany; Department of Molecular Medicine, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran 1449614535, Iran. Electronic address: ardestani.amin@gmail.com.

Publikováno v: Cell reports [Cell Rep] 2021 Aug 03; Vol. 36 (5), pp. 109490.