Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Maddocks, Oliver D.K."'
Autor:
Sun, Congxin, Seranova, Elena, Cohen, Malkiel A., Chipara, Miruna, Roberts, Jennie, Astuti, Dewi, Palhegyi, Adina M., Acharjee, Animesh, Sedlackova, Lucia, Kataura, Tetsushi, Otten, Elsje G., Panda, Prashanta K., Lara-Reyna, Samuel, Korsgen, Miriam E., Kauffman, Kevin J., Huerta-Uribe, Alejandro, Zatyka, Malgorzata, Silva, Luiz F.S.E., Torresi, Jorge, Zhang, Shupei, Hughes, Georgina W., Ward, Carl, Kuechler, Erich R., Cartwright, David, Trushin, Sergey, Trushina, Eugenia, Sahay, Gaurav, Buganim, Yosef, Lavery, Gareth G., Gsponer, Joerg, Anderson, Daniel G., Frickel, Eva-Maria, Rosenstock, Tatiana R., Barrett, Timothy, Maddocks, Oliver D.K., Tennant, Daniel A., Wang, Haoyi, Jaenisch, Rudolf, Korolchuk, Viktor I., Sarkar, Sovan
Publikováno v:
In Cell Reports 30 May 2023 42(5)
Autor:
Scopelliti, Alessandro, Bauer, Christin, Yu, Yachuan, Zhang, Tong, Kruspig, Björn, Murphy, Daniel J., Vidal, Marcos, Maddocks, Oliver D.K., Cordero, Julia B.
Publikováno v:
In Cell Metabolism 5 February 2019 29(2):269-284
Mitochondrial ROS signalling requires uninterrupted electron flow and is lost during ageing in flies
Autor:
Graham, Charlotte, Stefanatos, Rhoda, Yek, Angeline E.H., Spriggs, Ruth V., Loh, Samantha H.Y., Huerta Uribe, Alejandro, Zhang, Tong, Martins, L. Miguel, Maddocks, Oliver D.K., Scialo, Filippo, Sanz, Alberto
Mitochondrial reactive oxygen species (mtROS) are cellular messengers essential for cellular homeostasis. In response to stress, reverse electron transport (RET) through respiratory complex I generates high levels of mtROS. Suppression of ROS product
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::322dd6412f7e2b577d5a24102f62d31e
Publikováno v:
In Cell Metabolism 5 November 2013 18(5):617-633
Autor:
Marx, Christian, Sonnemann, Jürgen, Beyer, Mandy, Maddocks, Oliver D.K., Lilla, Sergio, Hauzenberger, Irene, Piée‐Staffa, Andrea, Siniuk, Kanstantsin, Nunna, Suneetha, Marx‐Blümel, Lisa, Westermann, Martin, Wagner, Tobias, Meyer, Felix B., Thierbach, René, Mullins, Christina S., Kdimati, Said, Linnebacher, Michael, Neri, Francesco, Heinzel, Thorsten, Wang, Zhao‐Qi, Krämer, Oliver H.
Publikováno v:
Molecular Oncology
Molecular Oncology, Vol 15, Iss 12, Pp 3404-3429 (2021)
Molecular Oncology, Vol 15, Iss 12, Pp 3404-3429 (2021)
Late‐stage colorectal cancer (CRC) is still a clinically challenging problem. The activity of the tumor suppressor p53 is regulated via post‐translational modifications (PTMs). While the relevance of p53 C‐terminal acetylation for transcription
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cde0064ce3798f2f8b20b7b4eb3317f4
https://eprints.gla.ac.uk/248531/1/248531.pdf
https://eprints.gla.ac.uk/248531/1/248531.pdf
Autor:
Zhang, Tong, Bauer, Christin, Newman, Alice C., Uribe, Alejandro Huerta, Athineos, Dimitris, Blyth, Karen, Maddocks, Oliver D.K.
Cancer cells have high demands for non-essential amino acids (NEAAs), which are precursors for anabolic and antioxidant pathways that support cell survival and proliferation. It is well-established that cancer cells consume the NEAA cysteine, and tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::cc803f6274fd8ed5bd773be31adccba5
https://eprints.gla.ac.uk/223346/4/223346.pdf
https://eprints.gla.ac.uk/223346/4/223346.pdf
Autor:
Falcone, Mattia, Maddocks, Oliver D.K.
Publikováno v:
Nature Cell Biology. 22:139-140
Understanding the metabolic rewiring of pancreatic ductal adenocarcinoma is an emerging strategy for identifying cancer-associated liabilities and improving treatment. A new study now elucidates the function of the transaminase BCAT2 in the early sta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fa0913eb406cf1ecf0931b70f25dfe5
https://doi.org/10.1038/s41556-020-0467-2
https://doi.org/10.1038/s41556-020-0467-2
Autor:
Greenwood, Hannah E., McCormick, Patrick, Gendron, Thibault, Glaser, Matthias, Pereira, Raul, Maddocks, Oliver D.K., Sander, Kerstin, Zhang, Tong, Koglin, Norman, Lythgoe, Mark F., Årstad, Erik, Hochhauser, Daniel, Witney, Timothy H.
Publikováno v:
Greenwood, H, McCormick, P, Gendron, T, Glaser, M, Pereira, R G, Maddocks, O, Sander, K, Zhang, T, Koglin, N, Lythgoe, M, Årstad, E, Hochhauser, D & Witney, T H 2019, ' Measurement of tumor antioxidant capacity and prediction of chemotherapy resistance in preclinical models of ovarian cancer by positron emission tomography ', Clinical Cancer Research, vol. 25, no. 8, pp. 2471-2482 . https://doi.org/10.1158/1078-0432.CCR-18-3423
Purpose: Drug-resistance is a major obstacle for the effective treatment of patients with high grade serous ovarian cancer (HGSOC). Currently, there is no satisfactory way to identify HGSOC patients that are refractive to the standard of care. Here,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::1f1f23fa91f8520e7e7a9d7a6fc83857
https://eprints.gla.ac.uk/177811/7/177811.pdf
https://eprints.gla.ac.uk/177811/7/177811.pdf
Autor:
McCormick, Patrick N., Greenwood, Hannah E., Glaser, Matthias, Maddocks, Oliver D.K., Gendron, Thibault, Sander, Kerstin, Gowrishankar, Gayatri, Hoehne, Aileen, Zhang, Tong, Shuhendler, Adam J., Lewis, David Y., Berndt, Mathias, Koglin, Norman, Lythgoe, Mark F., Gambhir, Sanjiv S., Årstad, Erik, Witney, Timothy H.
The cell's endogenous antioxidant system is vital to maintenance of redox homeostasis. Despite its central role in normal and pathophysiology, no non-invasive tools exist to measure this system in patients. The cystine/glutamate antiporter system xc-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::c18cfc2d0a3cd6e99da808e00e9ea39c
https://eprints.gla.ac.uk/177801/7/177801.pdf
https://eprints.gla.ac.uk/177801/7/177801.pdf
Autor:
Papalazarou, Vasileios1 (AUTHOR), Maddocks, Oliver D.K.1 (AUTHOR) oliver.maddocks@glasgow.ac.uk
Publikováno v:
Molecular Cell. Sep2021, Vol. 81 Issue 18, p3731-3748. 18p.