Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Maddie R Lemieux"'
Autor:
Maddie R Lemieux, Bernhard Freigassner, Jessica L Hanson, Zahra Thathey, Mark R Opp, Charles A Hoeffer, Christopher D Link
Publikováno v:
PLoS ONE, Vol 19, Iss 6, p e0303901 (2024)
Human induced pluripotent stem cells (hiPSCs) derived into neurons offer a powerful in vitro model to study cellular processes. One method to characterize functional network properties of these cells is using multielectrode arrays (MEAs). MEAs can me
Externí odkaz:
https://doaj.org/article/66a68061811e4ec9ae912fcfbf232230
Autor:
Thomas J. LaRocca, Alyssa N. Cavalier, Christine M. Roberts, Maddie R. Lemieux, Pooja Ramesh, Micklaus A. Garcia, Christopher D. Link
Publikováno v:
Neurobiology of Disease, Vol 159, Iss , Pp 105493- (2021)
The amyloid beta (Aβ) peptide is believed to play a central role in Alzheimer's disease (AD), the most common age-related neurodegenerative disorder. However, the natural, evolutionarily selected functions of Aβ are incompletely understood. Here, w
Externí odkaz:
https://doaj.org/article/0434b43faf314aa190e7a45eaee064e2
Autor:
Katsuhiko Mitachi, Hyun Gi Yun, Sara M. Kurosu, Shakiba Eslamimehr, Maddie R. Lemieux, Lada Klaić, William M. Clemons, Michio Kurosu
Publikováno v:
ACS Omega, Vol 3, Iss 2, Pp 1726-1739 (2018)
Externí odkaz:
https://doaj.org/article/7f888f0e3c984d9c8fc374c766595958
Autor:
Yoshimasa Ishizaki, Maddie R. Lemieux, William M. Clemons, Shou M. Kurosu, Katsuhiko Mitachi, Michio Kurosu, Shakiba Eslamimehr
Publikováno v:
Organic Letters. 21:876-879
We have explored a method to convert a muraymycin biosynthetic intermediate 3 to an anticancer drug lead 2 for in vivo and thorough preclinical studies. Cu(OAc)(2) forms a stable complex with the amide 4 and it prevents electrophilic reactions at the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50ef48d59a3c73fad1ff7e1937f53c72
https://doi.org/10.1021/acs.orglett.8b03716
https://doi.org/10.1021/acs.orglett.8b03716
Autor:
Christine M. Roberts, Alyssa N. Cavalier, Thomas J. LaRocca, Christopher D. Link, Maddie R. Lemieux
SUMMARYThe amyloid beta (Aβ) peptide is believed to play a central role in Alzheimer’s disease (AD), the most common age-related neurodegenerative disorder. However, the natural, evolutionarily-selected functions of Aβ are incompletely understood
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::551d7609f6d8c767a231bdde4d8dd9f2
https://doi.org/10.1101/2020.09.28.316927
https://doi.org/10.1101/2020.09.28.316927
Publikováno v:
J Antibiot (Tokyo)
Discovery of new anti-tuberculosis (TB) drugs is a time-consuming process due to the slow-growing nature of Mycobacterium tuberculosis (Mtb). A requirement of biosafety level 3 (BSL-3) facility for performing research associated with Mtb is another l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::702d1ed6c4c7a25408f2981355781fc5
https://pubmed.ncbi.nlm.nih.gov/32472054
https://pubmed.ncbi.nlm.nih.gov/32472054
Autor:
Christopher D. Link, Alyssa N. Cavalier, Maddie R. Lemieux, Pooja Ramesh, Micklaus A. Garcia, Thomas J. LaRocca, Christine M. Roberts
Publikováno v:
Neurobiology of disease
Neurobiology of Disease, Vol 159, Iss, Pp 105493-(2021)
Neurobiology of Disease, Vol 159, Iss, Pp 105493-(2021)
The amyloid beta (Aβ) peptide is believed to play a central role in Alzheimer's disease (AD), the most common age-related neurodegenerative disorder. However, the natural, evolutionarily selected functions of Aβ are incompletely understood. Here, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc7da2b9d45ed0332fd79f5a83fd0cc8
https://doi.org/10.1016/j.nbd.2021.105493
https://doi.org/10.1016/j.nbd.2021.105493
Autor:
Maddie R. Lemieux, Ying Kong, Scott G. Franzblau, Yuehong Wang, Shajila Siricilla, Dong Yang, Katsuhiko Mitachi, Frank Park, Shakiba Eslamimehr, Michio Kurosu, Jeffrey D. Pressly
Pleuromutilin is a promising pharmacophore to design new antibacterial agents for Gram-positive bacteria. However, there are limited studies on the development of pleuromutilin analogues that inhibit growth of Mycobacterium tuberculosis (Mtb). In scr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e272db5c143e92eaa74de40634e7785
https://europepmc.org/articles/PMC6154393/
https://europepmc.org/articles/PMC6154393/
Autor:
Michio Kurosu, William M. Clemons, Sara M. Kurosu, Shakiba Eslamimehr, Hyun Gi Yun, Lada Klaić, Katsuhiko Mitachi, Maddie R. Lemieux
Publikováno v:
ACS Omega
ACS Omega, Vol 3, Iss 2, Pp 1726-1739 (2018)
ACS Omega, Vol 3, Iss 2, Pp 1726-1739 (2018)
The spectrum of antibacterial activity for the nucleoside antibiotic FR-900493 (1) can be extended by chemical modifications. We have generated a small focused library based on the structure of 1 and identified UT-17415 (9), UT-17455 (10), UT-17460 (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60ba16f671455ab5de4ede34dadf1d37
https://resolver.caltech.edu/CaltechAUTHORS:20180305-115252453
https://resolver.caltech.edu/CaltechAUTHORS:20180305-115252453
Autor:
Bernd Meibohm, Katsuhiko Mitachi, Junshu Yang, Maddie R. Lemieux, Michio Kurosu, Shajila Siricilla, Shakiba Eslamimehr, Yinduo Ji
Multidrug-resistant (MDR) Acinetobacter baumannii is one of the most difficult Gram-negative bacteria to treat and eradicate. In a cell-based screening of pleuromutilin derivatives against a drug sensitive A. baumannii strain, new molecules (2–4) e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eeffc54894ffff7cc4bd650470f8d7bb
https://europepmc.org/articles/PMC5469366/
https://europepmc.org/articles/PMC5469366/