Structure-guided design of direct-acting antivirals that exploit the gem-dimethyl effect and potently inhibit 3CL proteases of severe acute respiratory syndrome Coronavirus-2 (SARS-CoV-2) and middle east respiratory syndrome coronavirus (MERS-CoV)

Autor: Dampalla, Chamandi S., Miller, Matthew J., Kim, Yunjeong, Zabiegala, Alexandria, Nguyen, Harry Nhat, Madden, Trent K., Thurman, Hayden A., Machen, Alexandra J., Cooper, Anne, Liu, Lijun, Battaile, Kevin P., Lovell, Scott, Chang, Kyeong-Ok, Groutas, William C.

Publikováno v: In European Journal of Medicinal Chemistry 5 June 2023 254

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Broad-Spectrum Cyclopropane-Based Inhibitors of Coronavirus 3C-like Proteases: Biochemical, Structural, and Virological Studies.

Autor: Dampalla CS; Department of Chemistry and Biochemistry, Wichita State University, Wichita, Kansas 67260, United States., Nguyen HN; Department of Chemistry and Biochemistry, Wichita State University, Wichita, Kansas 67260, United States., Rathnayake AD; Department of Chemistry and Biochemistry, Wichita State University, Wichita, Kansas 67260, United States., Kim Y; Department of Diagnostic Medicine & Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, Kansas 66506, United States., Perera KD; Department of Diagnostic Medicine & Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, Kansas 66506, United States., Madden TK; Department of Chemistry and Biochemistry, Wichita State University, Wichita, Kansas 67260, United States., Thurman HA; Department of Chemistry and Biochemistry, Wichita State University, Wichita, Kansas 67260, United States., Machen AJ; Protein Structure and X-ray Crystallography Laboratory, The University of Kansas, Lawrence, Kansas 66047, United States., Kashipathy MM; Protein Structure and X-ray Crystallography Laboratory, The University of Kansas, Lawrence, Kansas 66047, United States., Liu L; Protein Structure and X-ray Crystallography Laboratory, The University of Kansas, Lawrence, Kansas 66047, United States., Battaile KP; NYX, New York Structural Biology Center, Upton, New York 11973, United States., Lovell S; Protein Structure and X-ray Crystallography Laboratory, The University of Kansas, Lawrence, Kansas 66047, United States., Chang KO; Department of Diagnostic Medicine & Pathobiology, College of Veterinary Medicine, Kansas State University, Manhattan, Kansas 66506, United States., Groutas WC; Department of Chemistry and Biochemistry, Wichita State University, Wichita, Kansas 67260, United States.

Publikováno v: ACS pharmacology & translational science [ACS Pharmacol Transl Sci] 2022 Dec 28; Vol. 6 (1), pp. 181-194. Date of Electronic Publication: 2022 Dec 28 (Print Publication: 2023).