Pharmacogenomics of hypertension in chronic kidney disease: the CKD-PGX study

Autor: Sher Sj, Eadon Mt, Todd C. Skaar, Arlene B. Chapman, Maddatu J, Miller Bw, Melo Ferreira R, Jing Su, Sinha Ad, Victoria M. Pratt, Sharon M. Moe, Ranjani N. Moorthi

BackgroundPatients with chronic kidney disease (CKD) often have uncontrolled hypertension despite polypharmacy. Pharmacogenomic drug-gene interactions (DGIs) may impact the metabolism or efficacy of antihypertensive agents. We hypothesized that provi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::36654d6eb29b450f5f5e6c49539d5b7f
https://doi.org/10.1101/2021.03.30.21254665

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Cigarette smoke exposure impairs β-cell function through activation of oxidative stress and ceramide accumulation.

Autor: Tong X; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA., Chaudhry Z; Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA., Lee CC; Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA., Bone RN; Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA., Kanojia S; Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA., Maddatu J; Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA., Sohn P; Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA; Department of Cellular and Integrative Physiology, Indiana University School of Medicine, Indianapolis, IN, USA., Weaver SA; Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA; Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, USA., Robertson MA; Indiana Bioscience Research Institute, Indianapolis, IN, USA., Petrache I; Division of Pulmonary and Critical Care Medicine, Department of Medicine, National Jewish Health, Denver, CO, USA. Electronic address: PetracheI@NJHealth.org., Evans-Molina C; Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA; Richard L. Roudebush VA Medical Center, Indianapolis, IN, USA; Department of Cellular and Integrative Physiology, Indiana University School of Medicine, Indianapolis, IN, USA; Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, USA; Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN, USA. Electronic address: cevansmo@iu.edu., Kono T; Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA; Richard L. Roudebush VA Medical Center, Indianapolis, IN, USA. Electronic address: konot@iu.edu.

Publikováno v: Molecular metabolism [Mol Metab] 2020 Jul; Vol. 37, pp. 100975. Date of Electronic Publication: 2020 Mar 13.