Cell survival following direct executioner-caspase activation

Autor: Maddalena Nano, James A. Mondo, Jacob Harwood, Varuzhan Balasanyan, Denise J. Montell

Publikováno v: Proceedings of the National Academy of Sciences. 120

Executioner-caspase activation has been considered a point-of-no-return in apoptosis. However, numerous studies report survival from caspase activation after treatment with drugs or radiation. An open question is whether cells can recover from direct

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a63062ca32f6abcb24d38faff607d8d7
https://doi.org/10.1073/pnas.2216531120

Author Correction: Genetic instability from a single S phase after whole-genome duplication

Autor: Simon Gemble, René Wardenaar, Kristina Keuper, Nishit Srivastava, Maddalena Nano, Anne-Sophie Macé, Andréa E. Tijhuis, Sara Vanessa Bernhard, Diana C. J. Spierings, Anthony Simon, Oumou Goundiam, Helfrid Hochegger, Matthieu Piel, Floris Foijer, Zuzana Storchová, Renata Basto

Publikováno v: Nature. 608:E27-E27

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b390e6282bd997583a1531781af67604
https://doi.org/10.1038/s41586-022-05099-w

Chromosomes function as a barrier to mitotic spindle bipolarity in polyploid cells

Autor: Carole Pennetier, Oumou Goundiam, Frances Edwards, Gaëlle Letort, Delphine Gogendeau, Maddalena Nano, Simon Gemble, Alix Goupil, Renata Basto

Publikováno v: Journal of Cell Biology
Journal of Cell Biology, 2020, 219 (4), pp.e201908006. ⟨10.1083/jcb.201908006⟩
Journal of Cell Biology, Rockefeller University Press, 2020, 219 (4), pp.e201908006. ⟨10.1083/jcb.201908006⟩
Journal of Cell Biology, Rockefeller University Press, 2020, 219 (4), ⟨10.1083/jcb.201908006⟩
The Journal of Cell Biology

Polyploid cells with extra centrosomes and extra DNA divide in a multipolar manner. Using Drosophila and cancer cells challenged in different ways and in silico modeling, Goupil et al. show that chromosomes act as a barrier inhibiting spindle pole co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e15ff6894917d5dcb07ce42399e169a5
https://hal.science/hal-03454921

Plk4 Regulates Centriole Asymmetry and Spindle Orientation in Neural Stem Cells

Autor: Anthony Simon, Yuu Kimata, Maddalena Nano, Victor Racine, Daniel W. Buster, Alix Goupil, John M. Ryniawec, Carole Pennetier, Davide Gambarotto, Renata Basto, Delphine Gogendeau, Gregory C. Rogers, Damien Blanc

Publikováno v: Developmental Cell
Developmental Cell, Elsevier, 2019, 50, pp.11-24.e10. ⟨10.1016/j.devcel.2019.04.036⟩
Developmental Cell, Elsevier, 2019, 50 (1), pp.11-24.e10. ⟨10.1016/j.devcel.2019.04.036⟩

Summary Defects in mitotic spindle orientation (MSO) disrupt the organization of stem cell niches impacting tissue morphogenesis and homeostasis. Mutations in centrosome genes reduce MSO fidelity, leading to tissue dysplasia and causing several disea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c652fcb130fbd30e59f665da1f99a21b
https://hal.archives-ouvertes.fr/hal-03454910

Chromosomes function as a barrier to mitotic spindle bipolarity in polyploid cells

Autor: Delphine Gogendeau, Maddalena Nano, Alix Goupil, Carole Pennetier, Gaëlle Letort, Renata Basto

Whole genome duplications (WGDs) are found in a variety of tumors and are associated with chromosomal instability (CIN) and poor prognosis [1,2]. When induced experimentally, through cytokinesis failure, polyploid cells generate tumors [3]. Cytokines

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eaf6832e92d83955b4ecb6a11381696d