Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Maddalena L. Zighetti"'
Publikováno v:
Thrombosis research. 203
Background Time in therapeutic range (TTR) measures the stability of the international normalized ratio in patients on vitamin K antagonists (VKA). Low values are associated with poor outcomes. Women were shown to have lower TTR than men, but the cau
Publikováno v:
Blood coagulationfibrinolysis : an international journal in haemostasis and thrombosis. 29(8)
The role of sex and gender in determining clinical presentation, diagnostic approach and outcomes of venous thromboembolism is not fully and systematically addressed, except for hormone-related events in women. A lack of knowledge is also apparent re
Publikováno v:
Haematologica. 92:694-697
Adjusting platelet count (PC) in platelet-rich plasma (PRP) using platelet-poor plasma (PPP) is recommended for platelet aggregation (PA) studies, but it could also affect PA independently of the decrease in PC. Analysis of aggregation tracings from
Autor:
Norbert W. Bischofberger, Joe Sennelo, Kenneth A. Jacobson, Aishe Chen, Xiaoquin Cheng, Bin Xu, Andrew Stephens, Hak Sung Kim, Gary Kirschenheuter, Maddalena L. Zighetti, Arthur F Greslin, Soon-Ai Kim, Marco Cattaneo, Gary Cook
Publikováno v:
J Med Chem
Activation by ADP of both P2Y(1) and P2Y(12) receptors in platelets contributes to platelet aggregation, and antagonists at these receptor subtypes have antithrombotic properties. In an earlier publication, we have characterized the SAR as P2Y(1) rec
Autor:
Marco Cattaneo, Michael Y. Tsai, Michelle Bignell, Emanuela Taioli, Paolo Bucciarelli, Maddalena L. Zighetti, Pier Mannuccio Mannucci
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 17:1662-1666
Abstract Hyperhomocysteinemia is a frequent risk factor for deep-vein thrombosis. A common mutation (C677T) in the gene encoding for methylenetetrahydrofolate reductase (MTHFR) is responsible, in the homozygous state, for decreased enzyme activity an
Autor:
Marco Cattaneo, Sergio Harari, Cristina R Falcon, Stefano Savoritto, Maddalena L. Zighetti, Pier Mannuccio Mannucci, Rossana Lombardi
Publikováno v:
Thrombosis Research. 85:279-282
Primary pulmonary hypertension is a disease of unknown etiology, characterised by the elevation of pulmonary arterial pressure eventually leading to right ventricular failure and death (1). Although the pathogenetic mechanisms are heterogeneous (1,2)
Autor:
Philippe Ohlmann, Jean-Pierre Cazenave, Christian Gachet, Rossana Lombardi, Maddalena L. Zighetti, Marco Cattaneo, Pier Mannuccio Mannucci
Publikováno v:
Thrombosis and Haemostasis. 77:0986-0990
SummaryBy the term “Primary Secretion Defect” (PSD), we mean a common heterogeneous group of congenital defects of platelet secretion, characterized by a normal primary wave of platelet aggregation induced by ADP and other agonists, a normal conc
Autor:
Marco Cattaneo, D. Guarneri, Rossana Lombardi, F. Tradati, P. M. Mannucci, Anna Lecchi, Maddalena L. Zighetti
Publikováno v:
Scopus-Elsevier
The antiparasite agent pentamidine has been shown to inhibit human platelet aggregation in vitro at concentrations that (potentially) may be attained in patient plasma after the administration of the drug by nebulizer. We measured platelet aggregatio
Autor:
Marco Cattaneo, Caterina Bressi, F. I. Pareti, Zaverio M. Ruggeri, Pier Mannuccio Mannucci, Maddalena L. Zighetti, Luca Carpinelli
Publikováno v:
Thrombosis and Haemostasis. 76:460-468
SummaryWe have evaluated platelet function in different subtypes of von Willebrand disease (vWD) by pushing blood through the capillarysized channels of a glass filter. Patients, including those with type IIB vWD, showed lower than normal platelet re
Publikováno v:
British Journal of Haematology. 88:826-829
The in vitro measurement of platelet aggregation (PA) at the high shear levels that can be found in the microcirculation may provide useful informations on primary haemostasis, which is usually explored in vivo with the skin bleeding time (BT). PA at