Preclinical models for prediction of immunotherapy outcomes and immune evasion mechanisms in genetically heterogeneous multiple myeloma

Autor: Marta Larrayoz, Maria J. Garcia-Barchino, Jon Celay, Amaia Etxebeste, Maddalen Jimenez, Cristina Perez, Raquel Ordoñez, Cesar Cobaleda, Cirino Botta, Vicente Fresquet, Sergio Roa, Ibai Goicoechea, Catarina Maia, Miren Lasaga, Marta Chesi, P. Leif Bergsagel, Maria J. Larrayoz, Maria J. Calasanz, Elena Campos-Sanchez, Jorge Martinez-Cano, Carlos Panizo, Paula Rodriguez-Otero, Silvestre Vicent, Giovanna Roncador, Patricia Gonzalez, Satoru Takahashi, Samuel G. Katz, Loren D. Walensky, Shannon M. Ruppert, Elisabeth A. Lasater, Maria Amann, Teresa Lozano, Diana Llopiz, Pablo Sarobe, Juan J. Lasarte, Nuria Planell, David Gomez-Cabrero, Olga Kudryashova, Anna Kurilovich, Maria V. Revuelta, Leandro Cerchietti, Xabier Agirre, Jesus San Miguel, Bruno Paiva, Felipe Prosper, Jose A. Martinez-Climent

The historical lack of preclinical models reflecting the genetic heterogeneity of multiple myeloma (MM) hampers the advance of therapeutic discoveries. To circumvent this limitation, we screened mice engineered to carry eight MM lesions (NF-κB, KRAS

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2563a745972cadf6c4af5126546113b9
https://hdl.handle.net/10171/65914

A Combination of Apple Vinegar Drink with Bacillus coagulans Ameliorates High Fat Diet-Induced Body Weight Gain, Insulin Resistance and Hepatic Steatosis

Autor: María Oneca, Miriam Araña, Maddalen Jimenez, Ignacio Encío, María J. Pajares, Germán Munilla, Raquel Urtasun, Joana Díaz-Gómez, Miguel Barajas, Paloma Torre

Publikováno v: Nutrients
Volume 12
Issue 9
Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
instname
Academica-e: Repositorio Institucional de la Universidad Pública de Navarra
Universidad Pública de Navarra
Nutrients, Vol 12, Iss 2504, p 2504 (2020)

Obesity is a worldwide epidemic characterized by excessive fat accumulation, associated with multiple comorbidities and complications. Emerging evidence points to gut microbiome as a driving force in the pathogenesis of obesity. Vinegar intake, a tra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7544ca6380fe46a26b3fdc918b171aa6

SLU7 downregulation potentiates liver damage through hepatic de-differentiation

Autor: María Gárate-Rascón, Miriam Recalde, Maddalen Jimenez, María Elizalde, María Azkona, Marina Bárcena-Varela, Leticia Colyn, Maria U Latasa, Iker Uriarte, Maite G Fernandez-Barrena, Matías A Avila, Maria Arechederra, Carmen Berasain

Publikováno v: Journal of Hepatology. 73:S212

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4cbd1c39c00aa8a477c03d2dc24df31d
https://doi.org/10.1016/s0168-8278(20)30930-2

Splicing alterations contributing to cancer hallmarks in the liver: central role of dedifferentiation and genome instability

Autor: Carmen Berasain, Matías A. Avila, María Arechederra, Maddalen Jimenez

Publikováno v: Translational gastroenterology and hepatology. 3

Hepatocellular carcinoma (HCC) is a major cause of cancer-related death worldwide. HCCs are molecularly heterogeneous tumors, and this complexity is to a great extent responsible for their poor response to conventional and targeted therapies. In this

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::981e9419f5e19ed80140f71d1ca1cfed
https://pubmed.ncbi.nlm.nih.gov/30505971

Bile acids, FGF15/19 and liver regeneration: From mechanisms to clinical applications

Autor: Gloria Alvarez-Sola, Eva Santamaría, Raquel Urtasun, Marina Bárcena-Varela, Jesús Prieto, Matías A. Avila, Maria U. Latasa, C.M. Rodriguez-Ortigosa, Pedro Berraondo, Maddalen Jimenez, Iker Uriarte, Maite G. Fernandez-Barrena, Carmen Berasain

Publikováno v: Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease

The liver has an extraordinary regenerative capacity rapidly triggered upon injury or resection. This response is intrinsically adjusted in its initiation and termination, a property termed the "hepatostat". Several molecules have been involved in li

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::584e22fd6b9d3596498282fb750c7caa