Stochastic neuropeptide signals compete to calibrate the rate of satiation.

Autor: Zhang SX; Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA. x.stephen.zhang@gmail.com., Kim A; Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA., Madara JC; Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA., Zhu PK; Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA., Christenson LF; Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA., Lutas A; Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.; Diabetes, Endocrinology and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA., Kalugin PN; Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA., Sunkavalli PS; Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA., Jin Y; Department of Biochemistry and Molecular Medicine, School of Medicine, University of California, Davis, Sacramento, CA, USA.; Neuroscience Graduate Group, Center for Neuroscience, University of California, Davis, Sacramento, CA, USA.; Max Planck Florida Institute for Neuroscience, One Max Planck Way, Jupiter, FL, USA., Pal A; Department of Biochemistry and Molecular Medicine, School of Medicine, University of California, Davis, Sacramento, CA, USA.; Max Planck Florida Institute for Neuroscience, One Max Planck Way, Jupiter, FL, USA., Tian L; Department of Biochemistry and Molecular Medicine, School of Medicine, University of California, Davis, Sacramento, CA, USA.; Max Planck Florida Institute for Neuroscience, One Max Planck Way, Jupiter, FL, USA., Lowell BB; Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA., Andermann ML; Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA. manderma@bidmc.harvard.edu.; Department of Neurobiology, Harvard Medical School, Boston, MA, USA. manderma@bidmc.harvard.edu.

Publikováno v: Nature [Nature] 2024 Nov 06. Date of Electronic Publication: 2024 Nov 06.

Neural basis for fasting activation of the hypothalamic-pituitary-adrenal axis.

Autor: Douglass AM; Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA., Resch JM; Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.; Department of Neuroscience and Pharmacology, University of Iowa Carver College of Medicine, Iowa City, IA, USA., Madara JC; Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA., Kucukdereli H; Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA., Yizhar O; Departments of Brain Sciences and Molecular Neuroscience, Weizmann Institute of Science, Rehovot, Israel., Grama A; Center for Brain Science, Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA, USA., Yamagata M; Center for Brain Science, Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA, USA., Yang Z; Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA., Lowell BB; Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA. blowell@bidmc.harvard.edu.; Program in Neuroscience, Harvard Medical School, Boston, MA, USA. blowell@bidmc.harvard.edu.

Publikováno v: Nature [Nature] 2023 Aug; Vol. 620 (7972), pp. 154-162. Date of Electronic Publication: 2023 Jul 26.

A synaptic amplifier of hunger for regaining body weight in the hypothalamus.

Autor: Grzelka K; Synaptic Transmission in Energy Homeostasis Group, Max Planck Institute for Metabolism Research, Gleueler Strasse 50, 50931 Cologne, Germany., Wilhelms H; Synaptic Transmission in Energy Homeostasis Group, Max Planck Institute for Metabolism Research, Gleueler Strasse 50, 50931 Cologne, Germany., Dodt S; Synaptic Transmission in Energy Homeostasis Group, Max Planck Institute for Metabolism Research, Gleueler Strasse 50, 50931 Cologne, Germany; Department of Neuronal Control of Metabolism, Max Planck Institute for Metabolism Research, Cologne, Germany., Dreisow ML; Synaptic Transmission in Energy Homeostasis Group, Max Planck Institute for Metabolism Research, Gleueler Strasse 50, 50931 Cologne, Germany., Madara JC; Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA., Walker SJ; Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA., Wu C; Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA., Wang D; Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA., Lowell BB; Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA; Program in Neuroscience, Harvard Medical School, Boston, MA 02215, USA. Electronic address: blowell@bidmc.harvard.edu., Fenselau H; Synaptic Transmission in Energy Homeostasis Group, Max Planck Institute for Metabolism Research, Gleueler Strasse 50, 50931 Cologne, Germany; Center for Endocrinology, Diabetes and Preventive Medicine (CEDP), University Hospital Cologne, Kerpener Strasse 26, 50924 Cologne, Germany; Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases (CECAD), University of Cologne, Joseph-Stelzmann-Straße 26, Cologne 50931, Germany. Electronic address: henning.fenselau@sf.mpg.de.

Publikováno v: Cell metabolism [Cell Metab] 2023 May 02; Vol. 35 (5), pp. 770-785.e5. Date of Electronic Publication: 2023 Mar 24.

Arginine-vasopressin mediates counter-regulatory glucagon release and is diminished in type 1 diabetes.

Autor: Kim A; Division of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center, Boston, United States.; Program in Neuroscience, Harvard Medical School, Boston, United States., Knudsen JG; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom.; Section for Cell Biology and Physiology, Department of Biology, University of Copenhagen, Copenhagen, Denmark., Madara JC; Division of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center, Boston, United States., Benrick A; Metabolic Research Unit, Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Göteborg, Sweden., Hill TG; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom., Abdul Kadir L; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom., Kellard JA; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom., Mellander L; Metabolic Research Unit, Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Göteborg, Sweden., Miranda C; Metabolic Research Unit, Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Göteborg, Sweden., Lin H; Alberta Diabetes Institute, Li Ka Shing Centre for Health Research Innovation, Edmonton, Canada., James T; Department of Clinical Biochemistry, John Radcliffe, Oxford NHS Trust, Oxford, United Kingdom., Suba K; Section of Cell Biology and Functional Genomics, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, United Kingdom., Spigelman AF; Alberta Diabetes Institute, Li Ka Shing Centre for Health Research Innovation, Edmonton, Canada., Wu Y; Metabolic Research Unit, Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Göteborg, Sweden., MacDonald PE; Alberta Diabetes Institute, Li Ka Shing Centre for Health Research Innovation, Edmonton, Canada., Wernstedt Asterholm I; Metabolic Research Unit, Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Göteborg, Sweden., Magnussen T; Center for Clinical Metabolic Research, Gentofte Hospital, Hellerup, Denmark., Christensen M; Center for Clinical Metabolic Research, Gentofte Hospital, Hellerup, Denmark.; Department of Clinical Pharmacology, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Vilsbøll T; Center for Clinical Metabolic Research, Gentofte Hospital, Hellerup, Denmark.; Department of Clinical Pharmacology, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark.; Steno Diabetes Center Copenhagen, Copenhagen, Denmark., Salem V; Section of Cell Biology and Functional Genomics, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, United Kingdom., Knop FK; Center for Clinical Metabolic Research, Gentofte Hospital, Hellerup, Denmark.; Department of Clinical Pharmacology, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark.; Steno Diabetes Center Copenhagen, Copenhagen, Denmark.; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Rorsman P; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom.; Metabolic Research Unit, Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Göteborg, Sweden., Lowell BB; Division of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center, Boston, United States.; Program in Neuroscience, Harvard Medical School, Boston, United States., Briant LJ; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom.; Department of Computer Science, University of Oxford, Oxford, United Kingdom.

Publikováno v: ELife [Elife] 2021 Nov 17; Vol. 10. Date of Electronic Publication: 2021 Nov 17.

Food cue regulation of AGRP hunger neurons guides learning.

Autor: Berrios J; Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA., Li C; Diabetes, Endocrinology and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.; National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD, USA., Madara JC; Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA., Garfield AS; Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.; Rhythm Pharmaceuticals, Boston, MA, USA., Steger JS; Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.; Nanodropper, Rochester, MN, USA., Krashes MJ; Diabetes, Endocrinology and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.; National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD, USA., Lowell BB; Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA. blowell@bidmc.harvard.edu.; Program in Neuroscience, Harvard Medical School, Boston, MA, USA. blowell@bidmc.harvard.edu.

Publikováno v: Nature [Nature] 2021 Jul; Vol. 595 (7869), pp. 695-700. Date of Electronic Publication: 2021 Jul 14.