Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Madani, Rachid"'
Autor:
James J. Harding, Ahmad Awada, Gael Roth, Thomas Decaens, Philippe Merle, Nuria Kotecki, Chantal Dreyer, Christelle Ansaldi, Madani Rachid, Soraya Mezouar, Agnes Menut, Eloïne Nadeige Bestion, Valérie Paradis, Philippe Halfon, Ghassan K. Abou-Alfa, Eric Raymond
Publikováno v:
Liver Cancer (2022)
Introduction - GNS561/Ezurpimtrostat is a first-in-class, orally bioavailable, small molecule that blocks cancer cell proliferation by inhibiting late-stage autophagy and dose-dependent build-up of enlarged lysosomes by interacting with the palmitoyl
Externí odkaz:
https://doaj.org/article/cf7d5dbef89547338c0183b3a48d91d0
Autor:
Eloïne Bestion, Zuzana Macek Jilkova, Jean-Louis Mège, Marie Novello, Keerthi Kurma, Seyedeh Tayebeh Ahmad Pour, Gilles Lalmanach, Lise Vanderlynden, Lionel Fizanne, Firas Bassissi, Madani Rachid, Jennifer Tracz, Jérôme Boursier, Jérôme Courcambeck, Cindy Serdjebi, Christelle Ansaldi, Thomas Decaens, Philippe Halfon, Sonia Brun
Publikováno v:
Therapeutic Advances in Chronic Disease, Vol 11 (2020)
Background: Hepatic fibrosis is the result of chronic liver injury that can progress to cirrhosis and lead to liver failure. Nevertheless, there are no anti-fibrotic drugs licensed for human use. Here, we investigated the anti-fibrotic activity of GN
Externí odkaz:
https://doaj.org/article/1f2c4f5fc156452bb5c3b4df23efc116
Autor:
Eloïne Bestion, Keivan Zandi, Sandrine Belouzard, Julien Andreani, Hubert Lepidi, Marie Novello, Clara Rouquairol, Jean-Pierre Baudoin, Madani Rachid, Bernard La Scola, Jean-Louis Mege, Jean Dubuisson, Raymond F. Schinazi, Soraya Mezouar, Philippe Halfon
Publikováno v:
Viruses, Vol 14, Iss 1, p 132 (2022)
Since December 2019, SARS-CoV-2 has spread quickly worldwide, leading to more than 280 million confirmed cases, including over 5,000,000 deaths. Interestingly, coronaviruses were found to subvert and hijack autophagic process to allow their viral rep
Externí odkaz:
https://doaj.org/article/62874bdbbb2a4425ae2a44915973e2a8
Autor:
Eloïne Bestion, Madani Rachid, Annemilaï Tijeras-Raballand, Gael Roth, Thomas Decaens, Christelle Ansaldi, Soraya Mezouar, Eric Raymond, Philippe Halfon
BackgroundPalmitoyl-protein thioesterase-1 (PPT1) is an exciting druggable target for inhibiting autophagy in cancer.MethodsIn this study, we aimed to evaluate the effects of ezurpimtrostat-targeting PPT1 in combination with an anti-PD-1 antibody in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c57e565bb84344f3b3c1899d74ad2dc3
https://doi.org/10.1101/2023.01.18.524541
https://doi.org/10.1101/2023.01.18.524541
Autor:
Jonathan Stauber, Maximilian G. Plach, Ahmed Hamaï, Jean-Pierre Baudoin, Philippe Halfon, Marie Novello, Madani Rachid, Eloïne Bestion, Zuzana Macek Jilkova, Soraya Mezouar, Lise Vanderlynden, Gilles Lalmanach, Gaël S. Roth, Raphael Legouffe, Jennifer Tracz, Thomas Schubert, Firas Bassissi, Thomas Decaens, Sonia Brun, Christelle Ansaldi, Cindy Serdjebi, Eric Raymond, Cyrille Drouot, Jérôme Courcambeck, Guillaume Jacquemot
Publikováno v:
Autophagy
Autophagy, 2022, 18 (3), pp.678-694. ⟨10.1080/15548627.2021.1988357⟩
Autophagy, Taylor & Francis, 2022, 18 (3), pp.678-694. ⟨10.1080/15548627.2021.1988357⟩
Autophagy, 2022, 18 (3), pp.678-694. ⟨10.1080/15548627.2021.1988357⟩
Autophagy, Taylor & Francis, 2022, 18 (3), pp.678-694. ⟨10.1080/15548627.2021.1988357⟩
International audience; Hepatocellular carcinoma is the most frequent primary liver cancer. Macroautophagy/autophagy inhibitors have been extensively studied in cancer but, to date, none has reached efficacy in clinical trials. In this study, we demo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::963947ad8357c65d781ce7a48a965de8
https://hal.science/hal-03677289
https://hal.science/hal-03677289
Autor:
Sonia, Brun, Eloïne, Bestion, Eric, Raymond, Firas, Bassissi, Zuzana Macek, Jilkova, Soraya, Mezouar, Madani, Rachid, Marie, Novello, Jennifer, Tracz, Ahmed, Hamaï, Gilles, Lalmanach, Lise, Vanderlynden, Raphael, Legouffe, Jonathan, Stauber, Thomas, Schubert, Maximilian G, Plach, Jérôme, Courcambeck, Cyrille, Drouot, Guillaume, Jacquemot, Cindy, Serdjebi, Gael, Roth, Jean-Pierre, Baudoin, Christelle, Ansaldi, Thomas, Decaens, Philippe, Halfon
Publikováno v:
Autophagy. 18(3)
Hepatocellular carcinoma is the most frequent primary liver cancer. Macroautophagy/autophagy inhibitors have been extensively studied in cancer but, to date, none has reached efficacy in clinical trials. In this study, we demonstrated that GNS561, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::23b1f81ed175fe2864bc202b9178e928
https://pubmed.ncbi.nlm.nih.gov/34740311
https://pubmed.ncbi.nlm.nih.gov/34740311
Autor:
Eloïne Bestion, Jilkova, Zuzana Macek, Jean-Louis Mège, Novello, Marie, Keerthi Kurma, Seyedeh Tayebeh Ahmad Pour, Lalmanach, Gilles, Vanderlynden, Lise, Fizanne, Lionel, Bassissi, Firas, Madani Rachid, Tracz, Jennifer, Boursier, Jérôme, Courcambeck, Jérôme, Serdjebi, Cindy, Ansaldi, Christelle, Decaens, Thomas, Halfon, Philippe, Brun, Sonia
Supplemental material, Supp_material_Bestion_et_al._review for GNS561 acts as a potent anti-fibrotic and pro-fibrolytic agent in liver fibrosis through TGF-β1 inhibition by Eloïne Bestion, Zuzana Macek Jilkova, Jean-Louis Mège, Marie Novello, Keer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61aad86408cd64319100e05c01c6c448
Autor:
Cindy Serdjebi, Eric Francois, Bruno Lacarelle, Gael Deplanque, Joseph Ciccolini, Jean-François Seitz, Madani Rachid, Laetitia Dahan, Abakar Abakar-Mahamat, Florence Gattacceca, Johan Gagnière, Francine Fein
Publikováno v:
Therapeutic Drug Monitoring. 39:290-296
Gemcitabine remains a pillar in pancreatic cancer treatment. However, toxicities are frequently observed. Dose adjustment based on therapeutic drug monitoring might help decrease the occurrence of toxicities. In this context, this work aims at descri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::883b5fc64b543772fd2334bbe76522e3
https://doi.org/10.1097/ftd.0000000000000399
https://doi.org/10.1097/ftd.0000000000000399
Autor:
Eloine, Bestion, Lalmanach, Gilles, Novello, Marie, Macek Jilkova, Zuzana, Bassissi, Firas, Lyse, Vanderlynden, Madani, Rachid, Fizanne, Lionel, Tracz, Jennifer, Courcambeck, Jérôme, Serdjebi, Cindy, Ansaldi, Christelle, Decaens, Thomas, Halfon, Philippe, Brun, Sonia
Publikováno v:
Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases (AASLD) / Liver Meeting
Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases (AASLD) / Liver Meeting, Nov 2019, Boston, MA, United States. pp.1268A-1269A
Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases (AASLD) / Liver Meeting, Nov 2019, Boston, MA, United States. pp.1268A-1269A
International audience
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::28386e789162e672ba8720dcd1a0597d
https://hal-amu.archives-ouvertes.fr/hal-02466561
https://hal-amu.archives-ouvertes.fr/hal-02466561
Autor:
Madani, Rachid, Annemilai, Tijeras-Raballand, Serdjebi, Cindy, Brun, Sonia, Ansaldi, Christelle, Raymond, Eric, Halfon, Philippe
Publikováno v:
HEPATOLOGY
Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases (AASLD) / Liver Meeting
Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases (AASLD) / Liver Meeting, Nov 2019, Boston, MA, United States. pp.1189A
Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases (AASLD) / Liver Meeting
Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases (AASLD) / Liver Meeting, Nov 2019, Boston, MA, United States. pp.1189A
International audience
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::c42d49afd6721e52e742b6137ff41dbb
https://hal-amu.archives-ouvertes.fr/hal-02466433
https://hal-amu.archives-ouvertes.fr/hal-02466433