Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Madan G. Luthra"'
Correlation of mutation profile and response in patients with myelofibrosis treated with ruxolitinib
Autor:
Madan G. Luthra, Srdan Verstovsek, Mark J. Routbort, Elias Jabbour, Rajesh R. Singh, Meenakshi Mehrotra, Kate J. Newberry, Hagop M. Kantarjian, Rajyalakshmi Luthra, Jorge E. Cortes, Fabio P.S. Santos, Taghi Manshouri, Sherry Pierce, Keyur P. Patel
Publikováno v:
Blood. 126:790-797
Although most patients with myelofibrosis (MF) derive benefit from ruxolitinib, some are refractory, have a suboptimal response, or quickly lose their response. To identify genes that may predict response to ruxolitinib, we performed targeted next-ge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5157eaa95373c3f784a0efb530c0aea6
https://doi.org/10.1182/blood-2015-03-633404
https://doi.org/10.1182/blood-2015-03-633404
Autor:
Angela Romans, Christina Hannah, Sharmila Anandasabapathy, Stephen G. Swisher, Yong Li, Rajyalakshmi Luthra, Constance Albarracin, Rajesh R. Singh, Wayne L. Hofstetter, Madan G. Luthra, Hui Yao, Asif Rashid, Dipen M. Maru, Ronald Abraham
Publikováno v:
The American Journal of Pathology. 174:1940-1948
Barrett’s esophagus (BE)/Barrett’s metaplasia (BM) is a recognized precursor of esophageal adenocarcinoma (EA) with an intermediary stage of dysplasia. The low yield and high cost of endoscopic screening of patients with BE underscores the need f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::897d99864b524f2e93136bd2f4829335
https://doi.org/10.2353/ajpath.2009.080718
https://doi.org/10.2353/ajpath.2009.080718
Autor:
Su S. Chen, Bedia A. Barkoh, Madan G. Luthra, Asif Rashid, Russell Broaddus, Dipen M. Maru, Joe Ensor, Angela Romans, Yisheng Li, Rajesh R. Singh, Christina Hannah, Rajyalakshmi Luthra, Constance Albarracin
Publikováno v:
Oncogene. 27:6667-6678
Suppression of annexin A1 (ANXA1), a mediator of apoptosis and inhibitor of cell proliferation, is well documented in various cancers but the underlying mechanism remains unknown. We investigated whether decreased ANXA1 expression was mediated by mic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e1a92d424e7035d58ba81e538eec780
https://doi.org/10.1038/onc.2008.256
https://doi.org/10.1038/onc.2008.256
Autor:
Madan G. Luthra, Jeong Hee Cho-Vega, Dan Jones, Francisco Vega, Patrick A. Lennon, Megan Breeden, Jaime Bailey, Rajyalakshmi Luthra, L. Jeffrey Medeiros
Publikováno v:
British Journal of Haematology. 142:216-226
To further characterize the genotypic features of splenic (S) and nodal (N) marginal zone lymphomas (MZL) we compared eight SMZL and five NMZL by array-based comparative genomic hybridization (aCGH). Arbitrarily, aberrations were divided into major i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8228b672f15242697bcf09d4fc799dd
https://doi.org/10.1111/j.1365-2141.2008.07176.x
https://doi.org/10.1111/j.1365-2141.2008.07176.x
Autor:
Michael J. Keating, Lynne V. Abruzzo, Rajyalakshmi Luthra, Lynn L. Barron, William G. Wierda, Dan Jones, Sameer S. Talwalkar, Susan O'Brien, Madan G. Luthra, Alessandra Ferrajoli, Rachel J. Newman, Keith Anderson, Kevin R. Coombes
Publikováno v:
The Journal of Molecular Diagnostics. 9:546-555
To develop a model incorporating relevant prognostic biomarkers for untreated chronic lymphocytic leukemia patients, we re-analyzed the raw data from four published gene expression profiling studies. We selected 88 candidate biomarkers linked to immu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ff027c57a926927b516fbf3b27a711f
https://doi.org/10.2353/jmoldx.2007.070001
https://doi.org/10.2353/jmoldx.2007.070001
Autor:
Rajyalakshmi Luthra, Jaffer A. Ajani, Asif Rashid, Madan G. Luthra, Li Zhang, Norio Fukami, Alexandria T. Phan, Joe Ensor, Julie G. Izzo, Tsung Teh Wu
Publikováno v:
Clinical Cancer Research. 13:912-919
Purpose: Resistance to preoperative chemoradiotherapy (CTXRT) in 75% of patients with esophageal adenocarcinoma (EAC) underscores the need for identification of biomarkers of CTXRT response. We previously noted an association between decreased expres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f138ee6356ee62b758d907441c684426
https://doi.org/10.1158/1078-0432.ccr-06-1577
https://doi.org/10.1158/1078-0432.ccr-06-1577
Autor:
Jaffer A. Ajani, Tseung Teh Wu, Sharmila Anandasabapathy, Madan G. Luthra, Walter N. Hittelman, K.S.Clifford Chao, Arlene M. Correa, Mien Chie Hung, Bharat B. Aggarwal, Julie G. Izzo, Rajyalakshmi Luthra
Publikováno v:
Seminars in oncology. 34(2 Suppl 1)
The dramatic increase in the incidence and poor overall survival rates of esophageal/gastroesophageal junction adenocarcinoma underscore the necessity to discover molecular markers that can be used for risk assessment, early diagnosis, and targeted t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8eeb14285dc9b21d1d59b6cfcdc811d3
https://pubmed.ncbi.nlm.nih.gov/17449347
https://pubmed.ncbi.nlm.nih.gov/17449347
Autor:
Raja Luthra, Keyur P. Patel, William G. Wierda, Nitin Jain, Michael J. Keating, Xinyan Lu, L. Jeffrey Medeiros, Mark J. Routbort, Madan G. Luthra, Rashmi Kanagal-Shamanna
Publikováno v:
Blood. 126:1730-1730
Widespread use of next-generation sequencing (NGS) based mutational analysis has identified recurrent mutations of prognostic significance in chronic lymphocytic leukemia/ small lymphocytic lymphoma (CLL/SLL). In addition to novel genes such as NOTCH
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::99e02593f631b9997c70dfce435db81b
https://doi.org/10.1182/blood.v126.23.1730.1730
https://doi.org/10.1182/blood.v126.23.1730.1730
Autor:
Jaffer A. Ajani, Madan G. Luthra, Li Zhang, Rajyalakshmi Luthra, In Seon Choi, Usha Malhotra, Enrique Lopez-Alvarez, Tsung Teh Wu, Julie G. Izzo
Publikováno v:
Seminars in oncology. 33(6 Suppl 11)
To identify a panel of biomarkers that predicts response of esophageal cancers to preoperative chemoradiation, our group profiled the gene expression of pretreatment cancer biopsies from patients with esophageal cancer. Six (32%) of these patients ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc3654476131ba5ccc0f4181d1157cff
https://pubmed.ncbi.nlm.nih.gov/17178277
https://pubmed.ncbi.nlm.nih.gov/17178277
Autor:
Tsung-Teh Wu, Madan G. Luthra, Zhongxing X. Liao, Bharat B. Aggarwal, S.G. Swisher, Robert S. Bresalier, RP Luthra, Walter N. Hittelman, Julie G. Izzo, L. Milas, Jaffer A. Ajani
Publikováno v:
Journal of Clinical Oncology. 23:4029-4029
4029 Background: The incidence of esophageal/gastroesophageal junction adenocarcinoma (E/GEJAC) is rapidly rising in Western countries. Chemo-radiotherapy (CT-XRT) followed by surgery has been used...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2746f5096ec771a99fb1798c8da3a908
https://doi.org/10.1200/jco.2005.23.16_suppl.4029
https://doi.org/10.1200/jco.2005.23.16_suppl.4029