Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Madalyn Won"'
In addition to scavenging exogenous cholesterol, the parasitic kinetoplastid Trypanosoma cruzi can endogenously synthesize sterols. Similar to fungal species, T. cruzi synthesizes ergostane type sterols and is sensitive to a class of azole inhibitors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d0cc81358bc5757a4da3672715577c2
https://doi.org/10.1101/2022.05.03.490464
https://doi.org/10.1101/2022.05.03.490464
Autor:
Marcus C. S. Lee, Edward Owen, James M. Murithi, Kerry McGowen, Beatriz Baragaña, Madeline R. Luth, Emma F. Carpenter, Jacquin C. Niles, Chris Walpole, Manu Vanaerschot, Rebecca E. K. Mandt, Sabine Ottilie, Ian H. Gilbert, Avinash S. Punekar, Charisse Flerida A. Pasaje, Krittikorn Kümpornsin, Aslı Akidil, João Pedro Pisco, Kelly Rubiano, Nimisha Mittal, David A. Fidock, Robert L. Summers, De Lin, Andy Plater, Sharon M. Shepherd, Elizabeth A. Winzeler, A. Hazel Dilmore, Andrew M. Shepherd, Amanda K. Lukens, Dyann F. Wirth, Madalyn Won, Josefine Striepen, Justin Munro, Manuel Llinás
Publikováno v:
Cell Chemical Biology. 29:191-201.e8
Summary We identify the Plasmodium falciparum acetyl-coenzyme A synthetase (PfAcAS) as a druggable target, using genetic and chemical validation. In vitro evolution of resistance with two antiplasmodial drug-like compounds (MMV019721 and MMV084978) s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80e3028ee2d6c74bf0739d4ebecac7eb
https://doi.org/10.1016/j.chembiol.2021.07.010
https://doi.org/10.1016/j.chembiol.2021.07.010
