Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Madalyn R. Fritch"'
Autor:
Shiqi Xiang, Zixuan Lin, Meagan J. Makarcyzk, Kanyakorn Riewruja, Yiqian Zhang, Xiurui Zhang, Zhong Li, Karen L. Clark, Eileen Li, Silvia Liu, Tingjun Hao, Madalyn R. Fritch, Peter G. Alexander, Hang Lin
Publikováno v:
Clinical and Translational Medicine, Vol 12, Iss 12, Pp n/a-n/a (2022)
Abstract Background Human multipotent progenitor cells (hiMPCs) created from induced pluripotent stem cells (iPSCs) represent a new cell source for cartilage regeneration. In most studies, bone morphogenetic proteins (BMPs) are needed to enhance tran
Externí odkaz:
https://doaj.org/article/e8827580f394402bbc112ead85bcb966
Autor:
Shiqi Xiang, Zhong Li, Madalyn R. Fritch, La Li, Sachin Velankar, Yuwei Liu, Jihee Sohn, Natasha Baker, Hang Lin, Rocky S. Tuan
Publikováno v:
Stem Cell Research & Therapy, Vol 12, Iss 1, Pp 1-17 (2021)
Abstract Background Human bone marrow-derived mesenchymal stem cells (hBMSCs) can differentiate into adipocytes upon stimulation and are considered an appropriate cell source for adipose tissue engineering. In addition to biochemical cues, the stiffn
Externí odkaz:
https://doaj.org/article/d2f00e44e7b444f6ade3018d68221614
Autor:
Zhong Li, Zixuan Lin, Silvia Liu, Haruyo Yagi, Xiurui Zhang, Lauren Yocum, Monica Romero‐Lopez, Claire Rhee, Meagan J. Makarcyzk, Ilhan Yu, Eileen N. Li, Madalyn R. Fritch, Qi Gao, Kek Boon Goh, Benjamen O'Donnell, Tingjun Hao, Peter G. Alexander, Bhushan Mahadik, John P. Fisher, Stuart B. Goodman, Bruce A. Bunnell, Rocky S. Tuan, Hang Lin
Publikováno v:
Advanced Science, Vol 9, Iss 21, Pp n/a-n/a (2022)
Abstract Diseases of the knee joint such as osteoarthritis (OA) affect all joint elements. An in vitro human cell‐derived microphysiological system capable of simulating intraarticular tissue crosstalk is desirable for studying etiologies/pathogene
Externí odkaz:
https://doaj.org/article/74a01e20f19b40abb97cd5398781aced
Autor:
Katelyn E. Lipa, Xiurui Zhang, Alexander Chang, Megan Yeung, Hang Lin, Guanghua Lei, Yuchen He, Madalyn R. Fritch, Peter G. Alexander, Ning Wang, Benjamin B. Rothrauff, Silvia Liu
Publikováno v:
Osteoarthritis and Cartilage. 30:302-314
Summary Objective In knee cartilage from patients with osteoarthritis (OA), both preserved cartilage and damaged cartilage are observed. In this study, we aim to compare preserved with damaged cartilage to identify the molecule(s) that may be respons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db3fa5bef0bf29d4428ff3c1e87260a0
https://doi.org/10.1016/j.joca.2021.11.002
https://doi.org/10.1016/j.joca.2021.11.002
Autor:
Hang Lin, Peter G. Alexander, Rocky S. Tuan, Stuart B. Goodman, Bruce A. Bunnell, Qi Gao, Madalyn R. Fritch, Eileen Li, Lauren Yocum, Xiurui Zhang, Haruyo Yagi, Ilhan Yu, Zhong Alan Li, Meagan J. Makarcyzk
Publikováno v:
J Vis Exp
The high prevalence of debilitating joint diseases like osteoarthritis (OA) poses a high socioeconomic burden. Currently, the available drugs that target joint disorders are mostly palliative. The unmet need for effective disease-modifying OA drugs (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90af832fb3bf003dd6662d1ceac38601
https://doi.org/10.3791/64186
https://doi.org/10.3791/64186
Publikováno v:
Biomaterials science. 9(14)
Hyaline cartilage in the knee joint is a soft tissue that is both stiff and elastic, which raises unique challenges in developing scaffolds for the repair of cartilage injury. In this study, we mixed poly-d,l-lactic acid/polyethylene glycol/poly-d,l-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e95ba4974108fb38aeb3e1e8a6424f02
https://pubmed.ncbi.nlm.nih.gov/34109952
https://pubmed.ncbi.nlm.nih.gov/34109952
Autor:
Evan J. Kilroy, Ying Tang, Peter G. Alexander, Yuhao Deng, Kazunori Shimomura, Rocky S. Tuan, Hang Lin, Jihee Sohn, Madalyn R. Fritch, Angela M. Beck
Publikováno v:
Journal of Tissue Engineering and Regenerative Medicine. 13:1418-1429
There is no therapy currently available for fully repairing articular cartilage lesions. Our laboratory has recently developed a visible light-activatable methacrylated gelatin (mGL) hydrogel, with the potential for cartilage regeneration. In this st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6df14fadee2a3869f65e75a423bae617
https://doi.org/10.1002/term.2883
https://doi.org/10.1002/term.2883
Enhancing the potential of aged human articular chondrocytes for high‐quality cartilage regeneration
Publikováno v:
FASEB J
Autologous chondrocyte implantation (ACI) is a regenerative procedure used to treat focal articular cartilage defects in knee joints. However, age has been considered as a limiting factor, and ACI is not recommended for patients older than 40–50 ye
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::111aba81f6ef80379336f03af4e2d8a0
https://doi.org/10.1096/fj.202002386r
https://doi.org/10.1096/fj.202002386r
Autor:
Rocky S. Tuan, Madalyn R. Fritch, Hang Lin, Zhong Li, Peter G. Alexander, Shiqi Xiang, Eileen N. Li
Publikováno v:
Organotypic Models in Drug Development ISBN: 9783030700621
Handb Exp Pharmacol
Handb Exp Pharmacol
Musculoskeletal injuries and associated conditions are the leading cause of physical disability worldwide. The concept of tissue engineering has opened up novel approaches to repair musculoskeletal defects in a fast and/or efficient manner. Biomateri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::299dfba62cba6a8c7d138e90115d11f9
https://doi.org/10.1007/164_2020_377
https://doi.org/10.1007/164_2020_377
Publikováno v:
Stem Cell Research & Therapy, Vol 9, Iss 1, Pp 1-15 (2018)
Stem Cell Research & Therapy
Stem Cell Research & Therapy
Background Adult mesenchymal stem cells (MSCs) are an important resource for tissue growth, repair, and regeneration. To utilize MSCs more effectively, a clear understanding of how they react to environmental cues is essential. Currently, relatively
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd467f147570540c11376799c071087a
http://link.springer.com/article/10.1186/s13287-018-0830-4
http://link.springer.com/article/10.1186/s13287-018-0830-4