Clinical and genetic landscape of treatment naive cervical cancer: Alterations in PIK3CA and in epigenetic modulators associated with sub-optimal outcomeResearch in context

Autor: Suzy Scholl, Marina Popovic, Anne de la Rochefordiere, Elodie Girard, Sylvain Dureau, Aljosa Mandic, Katarina Koprivsek, Nina Samet, Marius Craina, Madalin Margan, Sanne Samuels, Henry Zijlmans, Gemma Kenter, Peter Hillemanns, Sorin Dema, Alis Dema, Goran Malenkovic, Branislav Djuran, Anne Floquet, Delphine Garbay, Frédéric Guyon, Pierre Emmanuel Colombo, Michel Fabbro, Christine Kerr, Charlotte Ngo, Fabrice Lecuru, Eleonor Rivin del Campo, Charles Coutant, Frédéric Marchal, Nathalie Mesgouez-Nebout, Virginie Fourchotte, Jean Guillaume Feron, Philippe Morice, Eric Deutsch, Pauline Wimberger, Jean-Marc Classe, Noreen Gleeson, Heiko von der Leyen, Mathieu Minsat, Coraline Dubot, Pierre Gestraud, Attila Kereszt, Istvan Nagy, Balazs Balint, Els Berns, Ekaterina Jordanova, Nicolas de Saint-Jorre, Alexia Savignoni, Nicolas Servant, Philippe Hupe, Leanne de Koning, Pierre Fumoleau, Roman Rouzier, Maud Kamal

Publikováno v: EBioMedicine, Vol 43, Iss , Pp 253-260 (2019)

Background: There is a lack of information as to which molecular processes, present at diagnosis, favor tumour escape from standard-of-care treatments in cervical cancer (CC). RAIDs consortium (www.raids-fp7.eu), conducted a prospectively monitored t

Externí odkaz: https://doaj.org/article/58ba860f2da840bab6a2ea3ac31257cf

p16/Ki-67 dual staining has a better accuracy than human papillomavirus (HPV) testing in women with abnormal cytology under 30 years old

Autor: Laurențiu Pirtea, Cristina Secosan, Madalin Margan, Lavinia Moleriu, Oana Balint, Dorin Grigoras, Ioan Sas, Florin Horhat, Adelina Jianu, Răzvan Ilina

Publikováno v: Biomolecules & Biomedicine, Vol 19, Iss 4 (2019)

Due to a high rate of transient human papillomavirus (HPV) infection, HPV genotyping has a low specificity for high-grade cervical lesions, especially in young women. p16/Ki-67 dual immunocytochemical staining can also be used for the detection of on

Externí odkaz: https://doaj.org/article/da671a62ff794b24b1ab924fb6248396

Clinical and Genetic Landscape of Treatment Naive Cervical Cancer: Alterations in PIK3CA and in Epigenetic Modulators Associated with Sub-Optimal Outcome

Autor: Fabrice Lecuru, Virginie Fourchotte, Mathieu Minsat, Jean Guillaume Feron, Nicolas Servant, Sanne Samuels, Sylvain Dureau, Katarina Koprivsek, Attila Kereszt, Roman Rouzier, István Nagy, Henry Zijlmans, Els Petronella Berns, Marina Popovic, Charlotte Ngo, Frédéric Guyon, Suzy Scholl, Peter Hillemanns, Michel Fabbro, Pierre Fumoleau, Eric Deutsch, Nicolas de Saint-Jorre, Ekaterina S. Jordanova, Jean-Marc Classe, Philippe Morice, Maud Kamal, Branislav Djuran, Pauline Wimberger, Akis Dema, Marius Craina, Noreen Gleeson, Elodie Girard, Heiko von der Leyen, Anne de la Rochefordiere, Gemma G. Kenter, Sorin Dema, Eleonor Rivin del Campo, Charles Coutant, Delphine Garbay, Goran Malenkovic, Philippe Hupé, Coraline Dubot, Nina Samet, Madalin Margan, Pierre Emmanuel Colombo, Balázs Bálint, Nathalie Mesgouez-Nebout, Alexia Savignoni, Aliosa Mandic, Christine Kerr, Leanne de Koning, Anne Floquet, Frédéric Marchal

Publikováno v: SSRN Electronic Journal.

Background: There is a lack of information as to which molecular processes, present at diagnosis, favor tumour escape from standard-of-care treatments in cervical cancer (CC). RAIDs consortium (www.raids-fp7.eu), conducted a prospectively monitored t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ad4b5ae500b5c8f3c325341428878582
https://doi.org/10.2139/ssrn.3346522

Individualized Follow-up of Pregnant Women with Asymptomatic Autoimmune Thyroid Disease

Autor: Madalin Margan, Bogdan Timar, Mihaela Craciunescu, Florin Borcan, Dana Stoian, Stelian Pantea, Marius Craina

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 17, Iss 1, p 88 (2016)
International Journal of Molecular Sciences; Volume 17; Issue 1; Pages: 88

Maternal hormones are essential for the normal fetal development during pregnancy. Autoimmune thyroid disease is a frequent pathology in our iodine replete region. The aim of this study is to evaluate the occurrence of subclinical hypothyroidism (SCH

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02451aa10ac8566199a2ee001ca6555b
https://doi.org/10.3390/ijms17010088