Zobrazeno 1 - 10
of 140
pro vyhledávání: '"Madalena M. Pinto"'
Autor:
Andreia Palmeira, Emília Sousa, Aylin Köseler, Ramazan Sabirli, Tarık Gören, İbrahim Türkçüer, Özgür Kurt, Madalena M. Pinto, M. Helena Vasconcelos
Publikováno v:
Pharmaceuticals, Vol 17, Iss 4, p 411 (2024)
There was an error in the original publication [...]
Externí odkaz:
https://doaj.org/article/8e08b066b8874a81a8cd97b6d340973a
Autor:
Joana Moreira, Joana B. Loureiro, Danilo Correia, Andreia Palmeira, Madalena M. Pinto, Lucília Saraiva, Honorina Cidade
Publikováno v:
Pharmaceuticals, Vol 16, Iss 10, p 1354 (2023)
We previously reported that chalcone CM-M345 (1) and diarylpentanoid BP-C4 (2) induced p53-dependent growth inhibitory activity in human cancer cells. Herein, CM-M345 (1) and BP-C4 (2) analogues were designed and synthesized in order to obtain more p
Externí odkaz:
https://doaj.org/article/8786cacc1ddf46e7a76db44d185ae506
Publikováno v:
Molecules, Vol 27, Iss 19, p 6340 (2022)
Diarylpentanoids, a class of natural products and their synthetic analogs which are structurally related to chalcones, have gained increasing attention due to their wide array of biological activities, including antitumor, anti-infective, antioxidant
Externí odkaz:
https://doaj.org/article/3b19289c1e9b4bf28333ac7950005f9a
Autor:
Andreia Palmeira, Emília Sousa, Aylin Köseler, Ramazan Sabirli, Tarık Gören, İbrahim Türkçüer, Özgür Kurt, Madalena M. Pinto, M. Helena Vasconcelos
Publikováno v:
Pharmaceuticals, Vol 13, Iss 6, p 132 (2020)
SARS-CoV-2 Spike protein was predicted by molecular docking to bind the host cell surface GRP78, which was suggested as a putative good molecular target to inhibit Covid-19. We aimed to confirm that GRP78 gene expression was increased in blood of SAR
Externí odkaz:
https://doaj.org/article/0daa7e9f7653410191f6fe3f2d1aaf35
Autor:
Raquel T. Lima, Diana Sousa, Ana Sara Gomes, Nuno Mendes, Rune Matthiesen, Madalena Pedro, Franklim Marques, Madalena M. Pinto, Emília Sousa, M. Helena Vasconcelos
Publikováno v:
Molecules, Vol 23, Iss 12, p 3301 (2018)
The search for novel anticancer small molecules and strategies remains a challenge. Our previous studies have identified TXA1 (1-{[2-(diethylamino)ethyl]amino}-4-propoxy-9H- thioxanthen-9-one) as a hit compound, with in vitro antitumor potential by m
Externí odkaz:
https://doaj.org/article/207f2290bfbb47868f5b9b29b2f67543
Autor:
Raquel T. Lima, Diana Sousa, Ana M. Paiva, Andreia Palmeira, João Barbosa, Madalena Pedro, Madalena M. Pinto, Emília Sousa, M. Helena Vasconcelos
Publikováno v:
Molecules, Vol 21, Iss 10, p 1343 (2016)
(1) Background: Our previous studies unveiled the hit thioxanthone TXA1 as an inhibitor of P-glycoprotein (drug efflux pump) and of human tumor cells growth, namely of melanoma cells. Since TXA1 is structurally similar to lucanthone (an autophagy inh
Externí odkaz:
https://doaj.org/article/17c9e17bb2314140a89e7864ca8fc7c2
Autor:
Joana Fonseca, Sandra Marques, Patrícia M. A. Silva, Pedro Brandão, Honorina Cidade, Madalena M. Pinto, Hassan Bousbaa
Publikováno v:
Molecules, Vol 21, Iss 8, p 982 (2016)
We previously reported that prenylated chalcone 2 (PC2), the O-prenyl derivative (2) of 2′-hydroxy-3,4,4′,5,6′-pentamethoxychalcone (1), induced cytotoxicity of tumor cells via disruption of p53-MDM2 interaction. However, the cellular changes t
Externí odkaz:
https://doaj.org/article/089a3a02e1d148f9a0a1bd1d1c3281bc
Autor:
João Barbosa, Raquel T. Lima, Diana Sousa, Ana Sara Gomes, Andreia Palmeira, Hugo Seca, Kantima Choosang, Pannee Pakkong, Hassan Bousbaa, Madalena M. Pinto, Emília Sousa, M. Helena Vasconcelos, Madalena Pedro
Publikováno v:
Molecules, Vol 21, Iss 1, p 81 (2016)
Our previous work has described a library of thioxanthones designed to have dual activity as P-glycoprotein modulators and antitumor agents. Some of these compounds had shown a significant cell growth inhibitory activity towards leukemia cell lines,
Externí odkaz:
https://doaj.org/article/967686b4f1a34e7684579ac54ed5d37d
Autor:
Andreia Palmeira, Maria Emília Sousa, Miguel X Fernandes, Madalena M. Pinto, M. Helena Vasconcelos
Publikováno v:
Journal of Pharmacy & Pharmaceutical Sciences, Vol 15, Iss 1 (2011)
Purpose. Aminated thioxanthones have recently been described as dual-acting agents: growth inhibitors of leukemia cell lines and P-glycoprotein (P-gp) inhibitors. To evaluate the selectivity profile of thioxanthones as inhibitors of multidrug resista
Externí odkaz:
https://doaj.org/article/b66c4b5a2d2c442cbf123b22be5bc758
Autor:
Ana Sara Gomes, Alexandra Correia, Antti Rahikkala, Ermei Mäkilä, Madalena M. Pinto, Emília Sousa, Jarno Salonen, Lucília Saraiva, Hélder A. Santos
Publikováno v:
International Journal of Pharmaceutics, 624. Elsevier Bedrijfsinformatie b.v.
Many drugs with anticancer potential fail in their translation to the clinics due to problems related to pharmacokinetics. LEM2 is a new dual inhibitor of MDM2/mutp53-TAp73 interactions with interesting in vitro anticancer activity, which opens new h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb36b8efa7358bb296c20859f01c3b29
https://doi.org/10.1016/j.ijpharm.2022.121959
https://doi.org/10.1016/j.ijpharm.2022.121959