Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Madalena M. M. Pinto"'
Autor:
José X. Soares, Inês Afonso, Adaleta Omerbasic, Daniela R. P. Loureiro, Madalena M. M. Pinto, Carlos M. M. Afonso
Publikováno v:
Molecules, Vol 28, Iss 10, p 4073 (2023)
The emergence of multiresistant bacteria and the shortage of antibacterials in the drug pipeline creates the need to search for novel agents. Evolution drives the optimization of the structure of marine natural products to act as antibacterial agents
Externí odkaz:
https://doaj.org/article/04396ae080b2475aa35de50946c31b1f
Publikováno v:
Chemosensors, Vol 10, Iss 8, p 340 (2022)
Lipophilicity is one of many parameters involved in the biological activity of drugs, as it affects their pharmacokinetic and pharmacodynamic behavior. Generally, lipophilicity is assessed by the partition coefficient of a compound between a nonpolar
Externí odkaz:
https://doaj.org/article/f600453428344c11981cf6ff5fb4070c
Autor:
José X. Soares, Daniela R. P. Loureiro, Ana Laura Dias, Salete Reis, Madalena M. M. Pinto, Carlos M. M. Afonso
Publikováno v:
Marine Drugs, Vol 20, Iss 1, p 58 (2022)
The marine environment is an important source of specialized metabolites with valuable biological activities. Xanthones are a relevant chemical class of specialized metabolites found in this environment due to their structural variety and their biolo
Externí odkaz:
https://doaj.org/article/d8892270aa10462fbe33d1cbf1310408
Publikováno v:
Molecules, Vol 26, Iss 18, p 5477 (2021)
Enantioselective chromatography is one of the most used techniques for the separation and purification of enantiomers. The most important issue for a specific successful enantioseparation is the selection of the suitable chiral stationary phase (CSP)
Externí odkaz:
https://doaj.org/article/cb0b6ff2dc5c4b04896315953220a258
Autor:
Solida Long, Izadora L. Furlani, Juliana M. de Oliveira, Diana I. S. P. Resende, Artur M. S. Silva, Luís Gales, José A. Pereira, Anake Kijjoa, Quezia B. Cass, Regina V. Oliveira, Emília Sousa, Madalena M. M. Pinto
Publikováno v:
Molecules, Vol 26, Iss 16, p 5070 (2021)
In recent decades, fungi-derived naturally occurring quinazolines have emerged as potential drug candidates. Nevertheless, most studies are conducted for bioactivity assays, and little is known about their absorption, distribution, metabolism, and el
Externí odkaz:
https://doaj.org/article/c02d9b09174f4208890f6eba6f7a3406
Autor:
Fernando Durães, Diana I. S. P. Resende, Andreia Palmeira, Nikoletta Szemerédi, Madalena M. M. Pinto, Gabriella Spengler, Emília Sousa
Publikováno v:
Antibiotics, Vol 10, Iss 5, p 600 (2021)
The emergence of multidrug and extensively drug-resistant pathogenic bacteria able to resist to the action of a wide range of antibiotics is becoming a growing problem for public health. The search for new compounds with the potential to help in the
Externí odkaz:
https://doaj.org/article/927e8f5e778d44d0b02dc8f1e375d8d2
Autor:
Solida Long, Joana B. Loureiro, Carla Carvalho, Luís Gales, Lucília Saraiva, Madalena M. M. Pinto, Ploenthip Puthongking, Emília Sousa
Publikováno v:
Molecules, Vol 26, Iss 6, p 1637 (2021)
The tumor suppressor p53 is inactivated by mutation in approximately 50% of human cancers. Small molecules that bind and stabilize those mutants may represent effective anticancer drugs. Herein, we report the tumor cell growth inhibitory activity of
Externí odkaz:
https://doaj.org/article/e4acd70a007b499faa2244492ea32ab3
Autor:
Madalena M. M. Pinto, Andreia Palmeira, Carla Fernandes, Diana I. S. P. Resende, Emília Sousa, Honorina Cidade, Maria Elizabeth Tiritan, Marta Correia-da-Silva, Sara Cravo
Publikováno v:
Molecules, Vol 26, Iss 2, p 431 (2021)
This work reviews the contributions of the corresponding author (M.M.M.P.) and her research group to Medicinal Chemistry concerning the isolation from plant and marine sources of xanthone derivatives as well as their synthesis, biological/pharmacolog
Externí odkaz:
https://doaj.org/article/c789f1e6a74b4ef9a087b5b4d855d8ff
Publikováno v:
Pharmaceuticals, Vol 13, Iss 9, p 242 (2020)
Alzheimer’s disease (AD) is a multifactorial disease characterized by the presence of amyloid plaques, neurofibrillary tangles, and nerve cell death that affects, mainly, older people. After decades of investigation, the search for an efficacious t
Externí odkaz:
https://doaj.org/article/a99b4ca0a8e54cdfa0e2d23d7de470f4
Autor:
Cátia Vilas-Boas, Francisca Carvalhal, Beatriz Pereira, Sílvia Carvalho, Emília Sousa, Madalena M. M. Pinto, Maria José Calhorda, Vitor Vasconcelos, Joana R. Almeida, Elisabete R. Silva, Marta Correia-da-Silva
Publikováno v:
Marine Drugs, Vol 18, Iss 10, p 489 (2020)
Marine biofouling represents a global economic and ecological challenge and few eco-friendly antifouling agents are available. The aim of this work was to establish the proof of concept that a recently synthesized nature-inspired compound (gallic aci
Externí odkaz:
https://doaj.org/article/7da32026226b4d73acef29574d21e440