Zobrazeno 1 - 10
of 80
pro vyhledávání: '"Madalena Chaves"'
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract Single-cell multimodal technologies reveal the scales of cellular heterogeneity impairing cancer treatment, yet cell response dynamics remain largely underused to decipher the mechanisms of drug resistance they take part in. As the phenotypi
Externí odkaz:
https://doaj.org/article/9fa5a24dec424b0e9ffb9978e6e36deb
Autor:
Madalena Chaves, Laurent Tournier
Publikováno v:
Frontiers in Physiology, Vol 9 (2018)
Boolean networks with asynchronous updates are a class of logical models particularly well adapted to describe the dynamics of biological networks with uncertain measures. The state space of these models can be described by an asynchronous state tran
Externí odkaz:
https://doaj.org/article/feca92002f844e5f8522d566b29f8389
Publikováno v:
PLoS ONE, Vol 6, Iss 2, p e17075 (2011)
Experimental observations performed in the p53-Mdm2 network, one of the key protein modules involved in the control of proliferation of abnormal cells in mammals, revealed the existence of two frequencies of oscillations of p53 and Mdm2 in irradiated
Externí odkaz:
https://doaj.org/article/ab38a12a7f4e4553b736afd0bcca1fd8
Publikováno v:
PLoS Computational Biology, Vol 5, Iss 1, p e1000256 (2009)
The concept of robustness of regulatory networks has received much attention in the last decade. One measure of robustness has been associated with the volume of the feasible region, namely, the region in the parameter space in which the system is fu
Externí odkaz:
https://doaj.org/article/f00bdf9d0d4b435e9244b7db41746772
Publikováno v:
International Journal of Robust and Nonlinear Control
International Journal of Robust and Nonlinear Control, 2022
International Journal of Robust and Nonlinear Control, 2022
International audience; The study of synchronization in coupled genetic networks is a very challenging topic that is usually analyzed on a case-by-case basis. Here we consider a general model of genetic networks and examine two forms of interconnecti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0a5d9bd3c96fe7609597de0a5fd4243
https://doi.org/10.1002/rnc.6061
https://doi.org/10.1002/rnc.6061
Publikováno v:
Interface Focus
Interface Focus, 2022, 12 (3), pp.20210087. ⟨10.1098/rsfs.2021.0087⟩
Interface Focus, 2022, 12 (3), pp.20210087. ⟨10.1098/rsfs.2021.0087⟩
International audience; The intercellular interactions between peripheral circadian clocks, located in tissues and organs other than the suprachiasmatic nuclei of the hypothalamus, are still very poorly understood. We propose a theoretical and comput
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1198e8bc9c2efbc00c478a6518d18593
https://hal.inria.fr/hal-03685352/document
https://hal.inria.fr/hal-03685352/document
Publikováno v:
Foundations of Systems Biology in Engineering (FOSBE)
Foundations of Systems Biology in Engineering (FOSBE), Aug 2022, Cambridge, Massachusetts, United States
Foundations of Systems Biology in Engineering (FOSBE), Aug 2022, Cambridge, Massachusetts, United States
International audience; Cell response heterogeneity upon drug treatment is a leading cause of reduced drug efficacy in preclinical cancer research. Although single-cell studies have revealed the depth of cellular heterogeneity observed between in tum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9b55df9a5d8ce5ad52146af47385645
https://hal.science/hal-03868311
https://hal.science/hal-03868311
Publikováno v:
IEEE Transactions on Automatic Control
IEEE Transactions on Automatic Control, 2022, ⟨10.1109/TAC.2022.3145653⟩
IEEE Transactions on Automatic Control, 2022, ⟨10.1109/TAC.2022.3145653⟩
International audience; In this paper we investigate the emergent dynamics in a network of N coupled cells, each expressing a similar genetic bistable switch. The bistable switch is modeled as a piecewise affine system and the cells are diffusively c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31113da71f3869eee86d57115a66b825
https://inria.hal.science/hal-02953502
https://inria.hal.science/hal-02953502
Publikováno v:
CHAOS 2021-6th IFAC Hybrid Conference on Analysis and Control of Chaotic Systems
CHAOS 2021-6th IFAC Hybrid Conference on Analysis and Control of Chaotic Systems, Sep 2021, Catania, Italy. ⟨10.1016/j.ifacol.2021.11.044⟩
CHAOS 2021-6th IFAC Hybrid Conference on Analysis and Control of Chaotic Systems, Sep 2021, Catania, Italy. ⟨10.1016/j.ifacol.2021.11.044⟩
International audience; In this paper, we study the diffusive coupling of a network of identical bistable switch piecewise-affine systems. We propose a control strategy which synchronizes every bistable switch subsystem of the network towards the sam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd914fedca6992ede4507b6673f14cc7
https://inria.hal.science/hal-03317956/file/chaos_1.pdf
https://inria.hal.science/hal-03317956/file/chaos_1.pdf
Autor:
Eleni Firippi, Madalena Chaves
Publikováno v:
FOSBE 2019-8th IFAC Conference on Foundations of Systems Biology in Engineering
FOSBE 2019-8th IFAC Conference on Foundations of Systems Biology in Engineering, Oct 2019, Valencia, Spain
FOSBE 2019-8th IFAC Conference on Foundations of Systems Biology in Engineering, Oct 2019, Valencia, Spain. ⟨10.1016/j.ifacol.2019.12.238⟩
FOSBE 2019-8th IFAC Conference on Foundations of Systems Biology in Engineering, Oct 2019, Valencia, Spain
FOSBE 2019-8th IFAC Conference on Foundations of Systems Biology in Engineering, Oct 2019, Valencia, Spain. ⟨10.1016/j.ifacol.2019.12.238⟩
International audience; Biological complex mechanisms with oscillatory behavior are often modeled by high dimensional nonlinear ODEs systems, which makes the analysis and understanding the dynamics of the system difficult. In this work, we consider t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9be7d3f388d495d2a4648158dc551d1
https://doi.org/10.1016/j.ifacol.2019.12.238
https://doi.org/10.1016/j.ifacol.2019.12.238