Zobrazeno 1 - 10
of 66
pro vyhledávání: '"Madalena, Tarsounas"'
Autor:
Florian J. Groelly, Rebecca A. Dagg, Jonathan Mailler, Thanos D. Halazonetis, Madalena Tarsounas
Publikováno v:
STAR Protocols, Vol 4, Iss 1, Pp 101970- (2023)
Summary: Cells experiencing DNA replication stress enter mitosis with under-replicated DNA, which activates a repair mechanism known as mitotic DNA synthesis (MiDAS). Here we describe a protocol to identify at genome wide and at high resolution the g
Externí odkaz:
https://doaj.org/article/474a7216b26e4b8d9a849050a8924633
Autor:
Florian J Groelly, Manuela Porru, Jutta Zimmer, Hugo Benainous, Yanti De Visser, Anastasiya A Kosova, Serena Di Vito, Violeta Serra, Anderson Ryan, Carlo Leonetti, Alejandra Bruna, Annamaria Biroccio, Madalena Tarsounas
Publikováno v:
EMBO Molecular Medicine, Vol 14, Iss 3, Pp 1-22 (2022)
Abstract The cells with compromised BRCA1 or BRCA2 (BRCA1/2) function accumulate stalled replication forks, which leads to replication‐associated DNA damage and genomic instability, a signature of BRCA1/2‐mutated tumours. Targeted therapies again
Externí odkaz:
https://doaj.org/article/02c619b0acf544c3b51f32c37322ca42
Autor:
Roberto Dinami, Luca Pompili, Eleonora Petti, Manuela Porru, Carmen D'Angelo, Serena Di Vito, Angela Rizzo, Virginia Campani, Giuseppe De Rosa, Alejandra Bruna, Violeta Serra, Miguel Mano, Mauro Giacca, Carlo Leonetti, Gennaro Ciliberto, Madalena Tarsounas, Antonella Stoppacciaro, Stefan Schoeftner, Annamaria Biroccio
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 1, Pp n/a-n/a (2023)
Abstract The telomeric repeat‐binding factor 2 (TRF2) is a telomere‐capping protein that plays a key role in the maintenance of telomere structure and function. It is highly expressed in different cancer types, and it contributes to cancer progre
Externí odkaz:
https://doaj.org/article/329d8d14529b400796d6b5c09e60a4e4
A transcription-based mechanism for oncogenic β-catenin-induced lethality in BRCA1/2-deficient cells
Autor:
Rebecca A. Dagg, Gijs Zonderland, Emilia Puig Lombardi, Giacomo G. Rossetti, Florian J. Groelly, Sonia Barroso, Eliana M. C. Tacconi, Benjamin Wright, Helen Lockstone, Andrés Aguilera, Thanos D. Halazonetis, Madalena Tarsounas
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Germline mutations in BRCA1 or BRCA2 tumour suppressor genes predispose to different cancers, as does oncogene activation. Here the authors reveal that aberrant transcription of specific genes triggered by activation of the oncogene β-catenin causes
Externí odkaz:
https://doaj.org/article/df2c21948aa4474d8a16c5c108679eec
Autor:
Timo Reisländer, Emilia Puig Lombardi, Florian J. Groelly, Ana Miar, Manuela Porru, Serena Di Vito, Benjamin Wright, Helen Lockstone, Annamaria Biroccio, Adrian Harris, Arturo Londoño-Vallejo, Madalena Tarsounas
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
BRCA2 plays important roles in cell physiology by promoting DNA replication and DNA double-strand breaks repair. Here the authors, reveal the impact of BRCA2 depletion on the cell transcriptional program with activation of the innate immune response
Externí odkaz:
https://doaj.org/article/a4c12a795f2a4463a4d0d639093cc868
Autor:
Eliana MC Tacconi, Sophie Badie, Giuliana De Gregoriis, Timo Reisländer, Xianning Lai, Manuela Porru, Cecilia Folio, John Moore, Arnaud Kopp, Júlia Baguña Torres, Deborah Sneddon, Marcus Green, Simon Dedic, Jonathan W Lee, Ankita Sati Batra, Oscar M Rueda, Alejandra Bruna, Carlo Leonetti, Carlos Caldas, Bart Cornelissen, Laurent Brino, Anderson Ryan, Annamaria Biroccio, Madalena Tarsounas
Publikováno v:
EMBO Molecular Medicine, Vol 11, Iss 7, Pp 1-16 (2019)
Abstract Due to compromised homologous recombination (HR) repair, BRCA1‐ and BRCA2‐mutated tumours accumulate DNA damage and genomic rearrangements conducive of tumour progression. To identify drugs that target specifically BRCA2‐deficient cell
Externí odkaz:
https://doaj.org/article/60b26d5b1f0d4fb1965e8459d8be9b33
Publikováno v:
Nature Reviews Cancer. 23:78-94
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b65eaa3c5b6eede9d31545a9a749343e
https://doi.org/10.1038/s41568-022-00535-5
https://doi.org/10.1038/s41568-022-00535-5
Autor:
Eliana MC Tacconi, Xianning Lai, Cecilia Folio, Manuela Porru, Gijs Zonderland, Sophie Badie, Johanna Michl, Irene Sechi, Mélanie Rogier, Verónica Matía García, Ankita Sati Batra, Oscar M Rueda, Peter Bouwman, Jos Jonkers, Anderson Ryan, Bernardo Reina‐San‐Martin, Joannie Hui, Nelson Tang, Alejandra Bruna, Annamaria Biroccio, Madalena Tarsounas
Publikováno v:
EMBO Molecular Medicine, Vol 9, Iss 10, Pp 1398-1414 (2017)
Abstract Maintenance of genome integrity requires the functional interplay between Fanconi anemia (FA) and homologous recombination (HR) repair pathways. Endogenous acetaldehyde, a product of cellular metabolism, is a potent source of DNA damage, par
Externí odkaz:
https://doaj.org/article/6bb88c58f3cf4cfc896831d828ae3700
Autor:
Xianning Lai, Ronan Broderick, Valérie Bergoglio, Jutta Zimmer, Sophie Badie, Wojciech Niedzwiedz, Jean-Sébastien Hoffmann, Madalena Tarsounas
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
BRCA2-deficient cells fail to complete replication in S-phase, which results in DNA bridges and chromosome mis-segregation at mitosis. Here the authors show that MUS81 helps BRCA2-deficient cells survive replication stress by activating mitotic DNA s
Externí odkaz:
https://doaj.org/article/a8a9dca4e29c43adad08bdc9e4343805
Autor:
Pepijn M. Schoonen, Francien Talens, Colin Stok, Ewa Gogola, Anne Margriet Heijink, Peter Bouwman, Floris Foijer, Madalena Tarsounas, Sohvi Blatter, Jos Jonkers, Sven Rottenberg, Marcel A. T. M. van Vugt
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Mutations in BRCA1 and BRCA2 render a cancer cell hypersensitive to PARP inhibitors but they can acquire resistance and relapse. Here the authors find that PARP inhibition leads to replication fork instability, cytokinesis failure and cell death, aid
Externí odkaz:
https://doaj.org/article/86272fb47c1c44e091878a6dfa6f26de