Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Madalena, Pedro"'
Autor:
Raquel T. Lima, Diana Sousa, Ana Sara Gomes, Nuno Mendes, Rune Matthiesen, Madalena Pedro, Franklim Marques, Madalena M. Pinto, Emília Sousa, M. Helena Vasconcelos
Publikováno v:
Molecules, Vol 23, Iss 12, p 3301 (2018)
The search for novel anticancer small molecules and strategies remains a challenge. Our previous studies have identified TXA1 (1-{[2-(diethylamino)ethyl]amino}-4-propoxy-9H- thioxanthen-9-one) as a hit compound, with in vitro antitumor potential by m
Externí odkaz:
https://doaj.org/article/207f2290bfbb47868f5b9b29b2f67543
Autor:
Raquel T. Lima, Diana Sousa, Ana M. Paiva, Andreia Palmeira, João Barbosa, Madalena Pedro, Madalena M. Pinto, Emília Sousa, M. Helena Vasconcelos
Publikováno v:
Molecules, Vol 21, Iss 10, p 1343 (2016)
(1) Background: Our previous studies unveiled the hit thioxanthone TXA1 as an inhibitor of P-glycoprotein (drug efflux pump) and of human tumor cells growth, namely of melanoma cells. Since TXA1 is structurally similar to lucanthone (an autophagy inh
Externí odkaz:
https://doaj.org/article/17c9e17bb2314140a89e7864ca8fc7c2
Autor:
João Barbosa, Raquel T. Lima, Diana Sousa, Ana Sara Gomes, Andreia Palmeira, Hugo Seca, Kantima Choosang, Pannee Pakkong, Hassan Bousbaa, Madalena M. Pinto, Emília Sousa, M. Helena Vasconcelos, Madalena Pedro
Publikováno v:
Molecules, Vol 21, Iss 1, p 81 (2016)
Our previous work has described a library of thioxanthones designed to have dual activity as P-glycoprotein modulators and antitumor agents. Some of these compounds had shown a significant cell growth inhibitory activity towards leukemia cell lines,
Externí odkaz:
https://doaj.org/article/967686b4f1a34e7684579ac54ed5d37d
Autor:
Madalena Pedro, Carlos Maurício Barbosa, Maria São José Nascimento, Maribel Teixeira, Madalena Pinto
Publikováno v:
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Interest on xanthones has been growing considerably due to their broad spectrum of biological activities. 1,3-Dihydroxy-2-methylxanthone (DHMXAN) showed a significant inhibitory effect on the growth of MCF-7 cancer cells. DHMXAN-loaded nanosphere and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36b4d46a12a50afbd7f70708e84b062b
https://hdl.handle.net/10216/127459
https://hdl.handle.net/10216/127459
Autor:
Franklim Marques, Rune Matthiesen, M. Helena Vasconcelos, Ana Sara Gomes, Madalena Pinto, Diana Sousa, Madalena Pedro, Nuno Mendes, Emília Sousa, Raquel T. Lima
Publikováno v:
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Molecules
Molecules, Vol 23, Iss 12, p 3301 (2018)
Volume 23
Issue 12
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Molecules
Molecules, Vol 23, Iss 12, p 3301 (2018)
Volume 23
Issue 12
The search for novel anticancer small molecules and strategies remains a challenge. Our previous studies have identified TXA1 (1-{[2-(diethylamino)ethyl]amino}-4-propoxy-9H-thioxanthen-9-one) as a hit compound, with in vitro antitumor potential by mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cb7f94361eb4a4725fc515035458a90
http://www.scopus.com/inward/record.url?scp=85058769923&partnerID=8YFLogxK
http://www.scopus.com/inward/record.url?scp=85058769923&partnerID=8YFLogxK
Autor:
Carlos A. M. Afonso, Diana Sousa, M. Helena Vasconcelos, João Paulo Peixoto Pena Barbosa, Salette Reis, Arlene G. Corrêa, Madalena Pinto, Carlos M. G. Azevedo, Raquel T. Lima, Madalena Pedro
Publikováno v:
Bioorganic & Medicinal Chemistry. 21:2941-2959
A promising antitumor xanthone derivative was optimized following a multidimensional approach that involved the synthesis of 17 analogues, the study of their lipophilicity and solubility, and the evaluation of their growth inhibitory activity on four
Autor:
Félix Carvalho, Juliana Faria, Odília Queirós, Joana Barbosa, Roxana Moreira, Madalena Pedro, Ricardo Jorge Dinis-Oliveira
Publikováno v:
Bioanalysis. 5:895-914
Alternative matrices are steadily gaining recognition as biological samples for toxicological analyses. Hair presents many advantages over traditional matrices, such as urine and blood, since it provides retrospective information regarding drug expos
Autor:
Diana C. G. A. Pinto, Madalena Pedro, Maria São José Nascimento, José A. S. Cavaleiro, Artur M. S. Silva, Joana Marinho, Claudio E. Sunkel
Publikováno v:
Biochemical Pharmacology. 75:826-835
4′-Methoxy-2-styrylchromone, a new synthetic chromone was identified as a selective proliferation inhibitor of human tumor (MCF-7 and NCI-H460) cell lines than to non-tumor cells (MRC-5). The antiproliferative activity of this chromone was also ext
Autor:
Hassan Bousbaa, Pannee Pakkong, Diana Sousa, Madalena Pinto, Hugo Seca, Ana Sara Gomes, Emília Sousa, Kantima Choosang, Mário Vasconcelos, Madalena Pedro, João Paulo Peixoto Pena Barbosa, Andreia Palmeira, Raquel T. Lima
Publikováno v:
Molecules
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Molecules, Vol 21, Iss 1, p 81 (2016)
Molecules; Volume 21; Issue 1; Pages: 81
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Molecules, Vol 21, Iss 1, p 81 (2016)
Molecules; Volume 21; Issue 1; Pages: 81
Our previous work has described a library of thioxanthones designed to have dual activity as P-glycoprotein modulators and antitumor agents. Some of these compounds had shown a significant cell growth inhibitory activity towards leukemia cell lines,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e28ef954b74371b92fbe805d0a691a3
https://hdl.handle.net/10216/120529
https://hdl.handle.net/10216/120529
Autor:
Madalena Pedro, Madalena Pinto, João F. Barbosa, Ana Paula de Almeida, José C. Quintela, Douglas Siqueira de Almeida Chaves
Publikováno v:
Revista Virtual de Química. 8
Plant-derived natural products remain an important source of biologically active substances for cancer treatment. The evaluation of the genus Cecropia for cytotoxic activity is still poorly investigated, particularly the specie Cecropia catharinensis