Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Mada Hashem"'
Publikováno v:
NeuroImage, Vol 250, Iss , Pp 118935- (2022)
Disruptions in oxidative metabolism may occur in multiple sclerosis and other demyelinating neurological diseases. The impact of demyelination on metabolic rate is also not understood. It is possible that mitochondrial damage may be associated with m
Externí odkaz:
https://doaj.org/article/27d0e39bb8bf4660b9bedefbf77cc20c
Publikováno v:
NeuroImage, Vol 206, Iss , Pp 116315- (2020)
Non-invasive quantitative imaging of cerebral oxygen metabolism (CMRO2) in small animal models is crucial to understand the role of oxidative metabolism in healthy and diseased brains. In this study, we developed a multimodal method combining near-in
Externí odkaz:
https://doaj.org/article/f9585b847e7a4e359a27ef4d3f2f31fb
Autor:
Milene Vandal, Adam Institoris, Ben Korin, Colin Gunn, Lee Suzie, Jiyeon Lee, Philippe Bourassa, Ramesh Mishra, Govind Peringod, Yulan Jiang, Sotaro Hirai, Camille Belzil, Louise Reveret, Cyntia Tremblay, Mada Hashem, William Meilandt, Oded Foreman, Meron Rouse-Girma, Wilten Nicola, Jakob Körbelin, Jeff F. Dunn, Andrew Braun, David Bennett, Grant Gordon, Frédéric Calon, Andrey Shaw, Minh Dang Nguyen
Genetic variations in CD2-associated protein (CD2AP) predispose to Alzheimer’s disease (AD) but the underlying mechanisms remain unknown. Here, we show that a cerebrovascular loss of CD2AP in AD is associated with cognitive decline and genetic down
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6d4992409ad8fa52795db5da442d82fa
https://doi.org/10.21203/rs.3.rs-1806158/v1
https://doi.org/10.21203/rs.3.rs-1806158/v1
Autor:
Jeff Dunn, Mada Hashem
Publikováno v:
Applied Magnetic Resonance. 52:1343-1377
Cerebral metabolic rate of oxygen (CMRO2) is a robust marker of brain health. It represents the amount of oxygen consumed by the brain, and it has been proved to be more sensitive indicator than oxygenation level and cerebral blood flow alone. Quanti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a1d62261d72436fc3e222dcc1a33cb00
https://doi.org/10.1007/s00723-021-01345-y
https://doi.org/10.1007/s00723-021-01345-y
Publikováno v:
Journal of Cerebral Blood Flow & Metabolism. :0271678X2311658
Quantifying relationships between cerebral blood flow (CBF), mitochondrial function (cytochrome c oxidase oxidation state), and metabolic rate of oxygen (CMRO2) could provide useful insight into normal neurovascular coupling, as well as regulation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::85f0ffdfce90f4ed6289f17d9dabae41
https://doi.org/10.1177/0271678x231165842
https://doi.org/10.1177/0271678x231165842
Publikováno v:
NeuroImage, Vol 250, Iss, Pp 118935-(2022)
Disruptions in oxidative metabolism may occur in multiple sclerosis and other demyelinating neurological diseases. The impact of demyelination on metabolic rate is also not understood. It is possible that mitochondrial damage may be associated with m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bb84a101b8274261d65e6beb27be4cf
https://pubmed.ncbi.nlm.nih.gov/35091079
https://pubmed.ncbi.nlm.nih.gov/35091079
Publikováno v:
Biomed Opt Express
We provide a protocol for measuring the absolute concentration of the oxidized and reduced state of cytochrome c oxidase (CCO) in the cerebral cortex of mice, using broadband continuous-wave NIRS. The algorithm (NIR-AQUA) allows for absolute quantifi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0289b25ddad7e1aa437eeab55b421a74
https://pubmed.ncbi.nlm.nih.gov/35003857
https://pubmed.ncbi.nlm.nih.gov/35003857
Autor:
Milène Vandal, Adam Institoris, Ben Korin, Colin Gunn, Suzie Lee, Jiyeon Lee, Philippe Bourassa, Ramesh C. Mishra, Govind Peringod, Yulan Jiang, Sotaro Hirai, Camille Belzil, Louise Reveret, Cyntia Tremblay, Mada Hashem, Esteban Elias, Bill Meilandt, Oded Foreman, Meron Rouse-Girma, Daniel Muruve, Wilten Nicola, Jakob Körbelin, Jeff F. Dunn, Andrew P. Braun, David A. Bennett, Grant R.J. Gordon, Frédéric Calon, Andrey S. Shaw, Minh Dang Nguyen
Cerebrovascular dysfunction is increasingly recognized as a major contributor to Alzheimer9s disease (AD). CD2-associated protein (CD2AP), an important predisposing factor for the disease, is enriched in the brain endothelium but the function of prot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1998f10f4debaf1c462de9f846894ca0
https://doi.org/10.1101/2020.12.10.419598
https://doi.org/10.1101/2020.12.10.419598
Publikováno v:
Neuroimage
NeuroImage, Vol 206, Iss, Pp 116315-(2020)
NeuroImage, Vol 206, Iss, Pp 116315-(2020)
Non-invasive quantitative imaging of cerebral oxygen metabolism (CMRO(2)) in small animal models is crucial to understand the role of oxidative metabolism in healthy and diseased brains. In this study, we developed a multimodal method combining near-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52a6ab4148e63bb3f9c51f5b092bbd6c
https://pubmed.ncbi.nlm.nih.gov/31669409
https://pubmed.ncbi.nlm.nih.gov/31669409
Autor:
Kartikeya Murari, Mada Hashem, Patrick J. Whelan, Linhui Yu, Elizabeth M S Thurston, Jeff Dunn
Publikováno v:
Biomed Opt Express
Hemodynamic parameters, such as tissue oxygen saturation and blood volume fraction, are important markers of brain physiology. They are also widely used surrogate markers of electrophysiological activity. Here, we present a single fiber spectroscopic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e27b815dc913173bfabbc3dd282b62c
https://doi.org/10.1364/boe.393295
https://doi.org/10.1364/boe.393295