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Targeting arginase-1 exerts antitumor effects in multiple myeloma and mitigates bortezomib-induced cardiotoxicity.

Autor: Ramji K; Department of Immunology, Medical University of Warsaw, 5 Nielubowicza Str., 02-097, Warsaw, Poland., Grzywa TM; Department of Immunology, Medical University of Warsaw, 5 Nielubowicza Str., 02-097, Warsaw, Poland.; Laboratory of Experimental Medicine, Medical University of Warsaw, 5 Nielubowicza Str., 02-097, Warsaw, Poland., Sosnowska A; Department of Immunology, Medical University of Warsaw, 5 Nielubowicza Str., 02-097, Warsaw, Poland., Paterek A; Department of Clinical Physiology, Centre of Postgraduate Medical Education, 99/103 Marymoncka Str., 01-813, Warsaw, Poland., Okninska M; Department of Clinical Physiology, Centre of Postgraduate Medical Education, 99/103 Marymoncka Str., 01-813, Warsaw, Poland., Pilch Z; Department of Immunology, Medical University of Warsaw, 5 Nielubowicza Str., 02-097, Warsaw, Poland., Barankiewicz J; Department of Hematology, Institute of Hematology and Transfusion Medicine, 14 Indiry Gandhi Str., 02-776, Warsaw, Poland., Garbicz F; Department of Experimental Hematology, Institute of Hematology and Transfusion Medicine, 14 Indiry Gandhi Str., 02-776, Warsaw, Poland.; Postgraduate School of Molecular Medicine, Medical University of Warsaw, 1B Banacha Str., 02-097, Warsaw, Poland., Borg K; Department of Diagnostic Hematology, Institute of Hematology and Transfusion Medicine, 14 Indiry Gandhi Str., 02-776, Warsaw, Poland., Bany-Laszewicz U; Department of Diagnostic Hematology, Institute of Hematology and Transfusion Medicine, 14 Indiry Gandhi Str., 02-776, Warsaw, Poland., Zerrouqi A; Department of Immunology, Medical University of Warsaw, 5 Nielubowicza Str., 02-097, Warsaw, Poland., Pyrzynska B; Department of Immunology, Medical University of Warsaw, 5 Nielubowicza Str., 02-097, Warsaw, Poland., Rodziewicz-Lurzynska A; Central Laboratory, University Clinical Center of Medical University of Warsaw, 1A Banacha Str., 02-097, Warsaw, Poland., Papiernik D; ExploRNA Therapeutics Ltd., 101 Zwirki I Wigury Str., 0.30, 02-089, Warsaw, Poland., Sklepkiewicz P; ExploRNA Therapeutics Ltd., 101 Zwirki I Wigury Str., 0.30, 02-089, Warsaw, Poland., Kedzierska H; ExploRNA Therapeutics Ltd., 101 Zwirki I Wigury Str., 0.30, 02-089, Warsaw, Poland., Staruch A; Department of Immunology, Medical University of Warsaw, 5 Nielubowicza Str., 02-097, Warsaw, Poland., Sadowski R; Department of Immunology, Medical University of Warsaw, 5 Nielubowicza Str., 02-097, Warsaw, Poland., Ciepiela O; Department of Laboratory Medicine, Medical University of Warsaw, 1A Banacha Str, 02-097, Warsaw, Poland., Lech-Maranda E; Department of Hematology, Institute of Hematology and Transfusion Medicine, 14 Indiry Gandhi Str., 02-776, Warsaw, Poland., Juszczynski P; Department of Experimental Hematology, Institute of Hematology and Transfusion Medicine, 14 Indiry Gandhi Str., 02-776, Warsaw, Poland., Mackiewicz U; Department of Clinical Physiology, Centre of Postgraduate Medical Education, 99/103 Marymoncka Str., 01-813, Warsaw, Poland., Maczewski M; Department of Clinical Physiology, Centre of Postgraduate Medical Education, 99/103 Marymoncka Str., 01-813, Warsaw, Poland., Nowis D; Department of Immunology, Medical University of Warsaw, 5 Nielubowicza Str., 02-097, Warsaw, Poland. dominika.nowis@wum.edu.pl.; Laboratory of Experimental Medicine, Medical University of Warsaw, 5 Nielubowicza Str., 02-097, Warsaw, Poland. dominika.nowis@wum.edu.pl., Golab J; Department of Immunology, Medical University of Warsaw, 5 Nielubowicza Str., 02-097, Warsaw, Poland. jakub.golab@wum.edu.pl.; Centre of Preclinical Research, Medical University of Warsaw, 1B Banacha Str., 02-097, Warsaw, Poland. jakub.golab@wum.edu.pl.

Publikováno v: Scientific reports [Sci Rep] 2022 Nov 16; Vol. 12 (1), pp. 19660. Date of Electronic Publication: 2022 Nov 16.

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Yap Is a Nutrient Sensor Sensitive to the Amino Acid L-Isoleucine and Regulates the Expression of Ctgf in Cardiomyocytes.

Autor: Nelson, Victoria L.^1,2,3 (AUTHOR), Eadie, Ashley L.^1,2,3 (AUTHOR), Perez, Lester^1,2,3 (AUTHOR), Madhu, Malav^1,2,3 (AUTHOR), Platt, Mathew^3,4 (AUTHOR), Mercer, Angella^2,3,5 (AUTHOR), Pulinilkunnil, Thomas^2,3,5 (AUTHOR), Kienesberger, Petra^2,3,5 (AUTHOR), Simpson, Jeremy A.^3,4 (AUTHOR), Brunt, Keith R.^1,2,3 (AUTHOR) keith.brunt@dal.ca

Publikováno v: Biomolecules (2218-273X). Oct2024, Vol. 14 Issue 10, p1299. 21p.

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