Výsledky vyhledávání - "Macrophages

CAGE sequencing reveals CFTR-dependent dysregulation of type I IFN signaling in activated cystic fibrosis macrophages

Autor: Jonathan L. Gillan, Mithil Chokshi, Gareth R. Hardisty, Sara Clohisey Hendry, Daniel Prasca-Chamorro, Nicola J. Robinson, Benjamin Lasota, Richard Clark, Lee Murphy, Moira K. B. Whyte, J. Kenneth Baillie, Donald J. Davidson, Gang Bao, Robert D. Gray

Publikováno v: Gillan, J L, Chokshi, M, Hardisty, G R, Clohisey Hendry, S, Prasca-Chamorro, D, Robinson, N J, Lasota, B, Clark, R, Murphy, L, Whyte, M K B, Baillie, J K, Davidson, D J, Bao, G & Gray, R D 2023, ' CAGE sequencing reveals CFTR-dependent dysregulation of type I IFN signaling in activated cystic fibrosis macrophages ', Science Advances, vol. 9, no. 21, eadg5128, pp. 1-17 . https://doi.org/10.1126/sciadv.adg5128

An intense, nonresolving airway inflammatory response leads to destructive lung disease in cystic fibrosis (CF). Dysregulation of macrophage immune function may be a key facet governing the progression of CF lung disease, but the underlying mechanism

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac1d6f49036f9327fdf6f94531d99523
https://www.pure.ed.ac.uk/ws/files/350052675/sciadv.adg5128.pdf

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Collagen type I alters the proteomic signature of macrophages in a collagen morphology-dependent manner

Autor: Gwenda F. Vasse, Sara Russo, Andrei Barcaru, Asmaa A. A. Oun, Amalia M. Dolga, Patrick van Rijn, Marcel Kwiatkowski, Natalia Govorukhina, Rainer Bischoff, Barbro N. Melgert

Publikováno v: Scientific Reports, 13(1):5670. Nature Publishing Group

Idiopathic pulmonary fibrosis is a progressive lung disease that causes scarring and loss of lung function. Macrophages play a key role in fibrosis, but their responses to altered morphological and mechanical properties of the extracellular matrix in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00227069f43390fb20eb873b57f12d13
https://doi.org/10.1038/s41598-023-32715-0

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Effective Transfection and Gene Silencing of Primary Murine Macrophages with Small Interfering RNA

Autor: van Kuijk, Kim, Nagenborg, Jan, Sluimer, Judith C, Ramji, Dipak

Publikováno v: Atherosclerosis: Methods and Protocols, 125-132
ISSUE=1;STARTPAGE=125;ENDPAGE=132;TITLE=Atherosclerosis
Methods in Molecular Biology ISBN: 9781071619230

Transfection of murine primary macrophages to silence genes can be a challenging procedure because this cell type has developed mechanisms to evade cellular intrusion. The introduction of small interfering RNA (siRNA) encapsulated in liposomes to the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd6c5663595e92a5dd74fb2f4ad18374
https://doi.org/10.1007/978-1-0716-1924-7_8

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Characterization of Lipopolysaccharide Effects on LRRK2 Signaling in RAW Macrophages

Autor: Asmaa Oun, Emmy Hoeksema, Ahmed Soliman, Famke Brouwer, Fabiola García-Reyes, Henderikus Pots, Marina Trombetta-Lima, Arjan Kortholt, Amalia M. Dolga

Publikováno v: International Journal of Molecular Sciences, 24(2):1644. MDPI AG
International Journal of Molecular Sciences; Volume 24; Issue 2; Pages: 1644

Dysfunction of the immune system and mitochondrial metabolism has been associated with Parkinson’s disease (PD) pathology. Mutations and increased kinase activity of leucine-rich repeat kinase 2 (LRRK2) are linked to both idiopathic and familial PD

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38fc3223a882551609f5baeb49e724f3
https://doi.org/10.3390/ijms24021644

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DOT1L regulates lipid biosynthesis and inflammatory responses in macrophages and promotes atherosclerotic plaque stability

Autor: Lisa Willemsen, Koen H.M. Prange, Annette E. Neele, Cindy P.A.A. van Roomen, Marion Gijbels, Guillermo R. Griffith, Myrthe den Toom, Linda Beckers, Ricky Siebeler, Nathanael J. Spann, Hung-Jen Chen, Laura A. Bosmans, Andrej Gorbatenko, Suzanne van Wouw, Noam Zelcer, Heinz Jacobs, Fred van Leeuwen, Menno P.J. de Winther

Publikováno v: Cell Reports, 41(8):111703. Cell Press
Cell reports, 41(8):111703. Cell Press

Macrophages are critical immune cells in inflammatory diseases, and their differentiation and function are tightly regulated by histone modifications. H3K79 methylation is a histone modification associated with active gene expression, and DOT1L is th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c05bb3dde3236461fb0442e54d9df7cd
https://cris.maastrichtuniversity.nl/en/publications/8e61cfc8-7c5e-4e6b-ab6b-cb1ba514a359

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Tumour-associated macrophages drive stromal cell-dependent collagen crosslinking and stiffening to promote breast cancer aggression

Publikováno v: Nature materials, vol 20, iss 4
Maller, O, Drain, A P, Barrett, A S, Borgquist, S, Ruffell, B, Zakharevich, I, Pham, T T, Gruosso, T, Kuasne, H, Lakins, J N, Acerbi, I, Barnes, J M, Nemkov, T, Chauhan, A, Gruenberg, J, Nasir, A, Bjarnadottir, O, Werb, Z, Kabos, P, Chen, Y-Y, Hwang, E S, Park, M, Coussens, L M, Nelson, A C, Hansen, K C & Weaver, V M 2021, ' Tumour-associated macrophages drive stromal cell-dependent collagen crosslinking and stiffening to promote breast cancer aggression ', Nature Materials, vol. 20, no. 4, pp. 548-559 . https://doi.org/10.1038/s41563-020-00849-5
Nature materials

Stromal stiffening accompanies malignancy, compromises treatment and promotes tumour aggression. Clarifying the molecular nature and the factors that regulate stromal stiffening in tumours should identify biomarkers to stratify patients for therapy a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b763b8a68e3e138bcaa445e6a01a159
https://doi.org/10.1038/s41563-020-00849-5

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The Interface of Tumour-Associated Macrophages with Dying Cancer Cells in Immuno-Oncology

Autor: Isaure Vanmeerbeek, Jannes Govaerts, Raquel S. Laureano, Jenny Sprooten, Stefan Naulaerts, Daniel M. Borras, Damya Laoui, Massimiliano Mazzone, Jo A. Van Ginderachter, Abhishek D. Garg

Publikováno v: Cells. 11:3890

Tumour-associated macrophages (TAMs) are essential players in the tumour microenvironment (TME) and modulate various pro-tumorigenic functions such as immunosuppression, angiogenesis, cancer cell proliferation, invasion and metastasis, along with res

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdfe0d31c1bb9ef5c6afb20c8a1e72d7
https://doi.org/10.3390/cells11233890

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Host Immune-Metabolic Adaptations Upon Mycobacterial Infections and Associated Co-Morbidities

Autor: Alba Llibre, Martin Dedicoat, Julie G. Burel, Caroline Demangel, Matthew K. O’Shea, Claudio Mauro

Publikováno v: Frontiers in Immunology
Frontiers in Immunology, 2021, 12, pp.747387. ⟨10.3389/fimmu.2021.747387⟩
Frontiers in Immunology, Vol 12 (2021)

Mycobacterial diseases are a major public health challenge. Their causative agents include, in order of impact, members of theMycobacterium tuberculosiscomplex (causing tuberculosis),Mycobacterium leprae(causing leprosy), and non-tuberculous mycobact

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6c8bd617d292a80678dcec0985a1d59
https://hal-pasteur.archives-ouvertes.fr/pasteur-03903851/document

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