The clock gene Bmal1 inhibits macrophage motility, phagocytosis, and impairs defense against pneumonia

Autor: John Blaikley, Gareth B. Kitchen, Tracy Hussell, Mudassar Iqbal, Robert Maidstone, Laura Matthews, Hannah J. Durrington, Peter S. Cunningham, James Bagnall, Nicola Begley, Matthew Baxter, Ben Saer, Toryn Poolman, Julie E. Gibbs, Andrew S. I. Loudon, David W. Ray, David H. Dockrell

Publikováno v: Kitchen, G B, Cunningham, P S, Poolman, T M, Iqbal, M, Maidstone, R, Baxter, M, Bagnall, J, Begley, N, Saer, B, Hussell, T, Matthews, L C, Dockrell, D H, Durrington, H J, Gibbs, J E, Blaikley, J F, Loudon, A S & Ray, D W 2020, ' The clock gene Bmal1 inhibits macrophage motility, phagocytosis, and impairs defense against pneumonia ', Proceedings of the National Academy of Sciences, vol. 117, no. 3, pp. 1543-1551 . https://doi.org/10.1073/pnas.1915932117

The circadian clock regulates many aspects of immunity. Bacterial infections are affected by time of day, but the mechanisms involved remain undefined. Here we show that loss of the core clock protein BMAL1 in macrophages confers protection against p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f2f3ec07d41a024bb148b8e2b4eb0d7
https://doi.org/10.1073/pnas.1915932117

Divergent effects on macrophage biomarkers soluble CD163 and CD206 in axial spondyloarthritis

Autor: Bent Deleuran, Oliver Hendricks, Holger Jon Møller, Line Dam Heftdal, Alice Christiansen, Bodil Arnbak, Anne Grethe Jurik, Stinne Ravn Greisen, Anne Gitte Loft, Berit Schiøttz-Christensen, René Østgård

Publikováno v: Heftdal, L D, Loft, A G, Hendricks, O, Ashouri Christiansen, A, Schiøttz-Christensen, B, Arnbak, B, Jurik, A G, Østgård, R, Winding Deleuran, B, Møller, H J & Greisen, S R 2018, ' Divergent effects on macrophage biomarkers soluble CD163 and CD206 in axial spondyloarthritis ', Scandinavian Journal of Clinical & Laboratory Investigation, vol. 78, no. 6, pp. 483-489 . https://doi.org/10.1080/00365513.2018.1500704
Heftdal, L D, Loft, A G, Hendricks, O, Ashouri Christiansen, A, Schiøttz-Christensen, B, Arnbak, B, Jurik, A G, Østgård, R, Winding Deleuran, B, Møller, H J & Greisen, S R 2018, ' Divergent effects on macrophage biomarkers soluble CD163 and CD206 in axial spondyloarthritis ', Scandinavian Journal of Clnical and Laboratory Investigation, vol. 78, no. 6, pp. 483-489 . https://doi.org/10.1080/00365513.2018.1500704

The chronic joint inflammation in axial spondyloarthritis (axSpA) is characterized by infiltration of activated macrophages. The haptoglobin-hemoglobin receptor CD163 and the mannose receptor CD206 are strongly expressed on M2c and M2a macrophages, r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f70fcdb90f5b06b8bf0159dc9b79660b
https://doi.org/10.1080/00365513.2018.1500704

Helical antimicrobial peptides assemble into protofibril scaffolds that present ordered dsDNA to TLR9

Autor: Ernest Y. Lee, Mandy Hung, Michel Gilliet, Changsheng Zhang, Veronica Veksler, Jeremy Di Domizio, Fan Jin, Will Connell, Pengyu Ren, Gerard C. L. Wong, Nicolas Malkoff

Publikováno v: Nature communications, vol 10, iss 1
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
Nature Communications
Nature communications, vol. 10, no. 1, pp. 1012

Amphiphilicity in ɑ-helical antimicrobial peptides (AMPs) is recognized as a signature of potential membrane activity. Some AMPs are also strongly immunomodulatory: LL37-DNA complexes potently amplify Toll-like receptor 9 (TLR9) activation in immune

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73e45c56c9b3fcde327e5251318035d4
https://escholarship.org/uc/item/0388t0qm

Induction of paracrine signaling in metastatic melanoma cells by PPARγ agonist rosiglitazone activates stromal cells and enhances tumor growth

Autor: Jürg Hafner, Bao Khanh Trang, Catherine Moret, Mitchell P. Levesque, Helene Moser, Thanh Nhan Nguyen, Liliane Michalik, Christine Goepfert, Pedro Romero, Christine Pich, Patrick Meylan, Camilla Jandus, Romain Loyon, Beatris Mastelic-Gavillet

Publikováno v: Cancer Research, Vol. 78, No 22 (2018) pp. 6447-6461

In addition to improving insulin sensitivity in type 2 diabetes, the thiazolidinedione family of compounds and the pharmacologic activation of their best-characterized target PPARγ have been proposed as a therapeutic option for cancer treatment. In

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f395a3c4d3390288cf5b5300fe9c4190
https://doi.org/10.5167/uzh-158449

Loss of intestinal sympathetic innervation elicits an innate immune driven colitis

Autor: Balthasar A. Heesters, Laurens Nijhuis, Margriet J. Vervoordeldonk, Patricia van Hamersveld, Wouter J. de Jonge, Caroline Verseijden, Olaf Welting, Sigrid E.M. Heinsbroek, Rose Willemze, Harold Darwinkel, Jurgen Seppen, Francisca W. Hilbers, Sybren L. Meijer, Philippe Blancou, Joost H.A. Folgering

Publikováno v: Molecular Medicine
Molecular Medicine, Vol 25, Iss 1, Pp 1-18 (2019)
Molecular medicine (Cambridge, Mass.), 25(1). Feinstein Institute for Medical Research

Background Both the parasympathetic and sympathetic nervous system exert control over innate immune responses. In inflammatory bowel disease, sympathetic innervation in intestinal mucosa is reduced. Our aim was to investigate the role of sympathetic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2495b0cc53efbb8acce20d85b85c5c8
https://pubmed.ncbi.nlm.nih.gov/30616543