Zobrazeno 1 - 10
of 152
pro vyhledávání: '"Macrolide synthesis"'
Publikováno v:
Chemistry – A European Journal. 27:2589-2611
Callyspongiolide, a macrolide natural product with a conjugated diene-ynic side chain, has garnered significant attention from the synthetic community since its isolation from a sea sponge in 2013. Herein, the approaches that have been applied to thi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92a531c72e7cf87534175a42f6c441bc
https://doi.org/10.1002/chem.202003898
https://doi.org/10.1002/chem.202003898
Publikováno v:
Molecules, Vol 16, Iss 7, Pp 5422-5436 (2011)
b-Hydroxy aldehyde and alkyl ketone moieties were effectively synthesized as key intermediates of amphidinolide Q, a cytotoxic macrolide from the cultured dinoflagellate Amphidinium sp.. The asymmetric center of the former derivative was produced by
Externí odkaz:
https://doaj.org/article/d51f42c87904411ea01cd4970468d77a
Publikováno v:
Helvetica Chimica Acta. 85:417-430
Two novel, potentially antimicrobial erythronolide aglycon analogs ((-)-9 and (-)-30, respectively), which incorporate a large number of contiguous stereogenic centers, have been prepared by multistep synthesis from simple chirons. The chemistry pres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fdf04b5343f63713f798814a169c780
https://doi.org/10.1002/1522-2675(200202)85:2<417::aid-hlca417>3.0.co
https://doi.org/10.1002/1522-2675(200202)85:2<417::aid-hlca417>3.0.co
Publikováno v:
Molecules, Vol 16, Iss 7, Pp 5422-5436 (2011)
Molecules; Volume 16; Issue 7; Pages: 5422-5436
Molecules
Molecules; Volume 16; Issue 7; Pages: 5422-5436
Molecules
β-hydroxy aldehyde and alkyl ketone moieties were effectively synthesized as key intermediates of amphidinolide Q, a cytotoxic macrolide from the cultured dinoflagellate Amphidinium sp.. The asymmetric center of the former derivative was produced by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78902d6d4c2cedd547924bf92b1372d5
http://www.mdpi.com/1420-3049/16/7/5422/
http://www.mdpi.com/1420-3049/16/7/5422/
Publikováno v:
Tetrahedron Letters. 43:6005-6008
The C21–C34 subunit 27 of the aplyronines, containing eight stereocentres and a terminal N-methyl-N-vinylformamide moiety, was prepared using the Horner–Wadsworth–Emmons coupling of β-ketophosphonate 5 with aldehyde 19 . The two stereotetrad s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::845caa7dd99cd2c4e6a71ebb57f06b6c
https://doi.org/10.1016/s0040-4039(02)01217-0
https://doi.org/10.1016/s0040-4039(02)01217-0
Autor:
Kazi A. Shahid, Syun-ichi Kiyooka
Publikováno v:
Tetrahedron Letters. 41:2633-2637
2,3- anti -Propionate aldols involving a 3,5- syn- or anti -diol subunit, versatile enantiopure segments available for macrolide synthesis, were prepared by a chiral oxazaborolidinone-promoted asymmetric aldol reaction with 2-bromo-1-ethoxy-2-methyl-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::40dc1a6da6dd326f768af1e999620485
https://doi.org/10.1016/s0040-4039(00)00234-3
https://doi.org/10.1016/s0040-4039(00)00234-3
Publikováno v:
Tetrahedron Letters. 50:5012-5014
The C11–C22 and C23–C35 segments 2 and 3 of reidispongiolide A (1), an actin-depolymerizing marine macrolide, were synthesized enantioselectively in 12 steps from (R)-glycidyl trityl ether and in 12 steps from chiral ketone 15, respectively.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d6d95f580f4bb2a05129dd6245596890
https://doi.org/10.1016/j.tetlet.2009.06.075
https://doi.org/10.1016/j.tetlet.2009.06.075
Publikováno v:
Tetrahedron Letters. 39:8545-8548
The C1C28 aldehyde 5, containing the AB- and CD-spiroacetal portions together with the bridging chain of spongistatin 1 (1), was prepared. The key step was a lithium-mediated, anti-aldol coupling between ethyl ketone 4 and aldehyde 6 under Felkin-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::75ccc1a03f8880b76c342f7626740b3e
https://doi.org/10.1016/s0040-4039(98)01908-x
https://doi.org/10.1016/s0040-4039(98)01908-x
Publikováno v:
Tetrahedron Letters. 39:6037-6040
The aplyronine C1C11 subunit 4, containing 4 stereocentres and the (E,E)-diene system, was prepared in 7 steps from ethyl ketone (R)-8 using a boron-mediated anti aldol reaction. The corresponding C15C27 subunit 5, containing 6 stereogenic cent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bd77c49a8250c55d1603d85094b92429
https://doi.org/10.1016/s0040-4039(98)01191-5
https://doi.org/10.1016/s0040-4039(98)01191-5
Publikováno v:
Tetrahedron Letters. 38:8911-8914
The C 16 C 28 ketone 3 , containing the CD-spiroacetal of spongistatin 1 ( 1 ), was prepared in 17 steps from aldehyde 9 . Both thermodynamic and kinetic conditions were explored for controlling the CD-acetal configuration.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::973b38fb1b52ae7fd2e757885bc91e09
https://doi.org/10.1016/s0040-4039(97)10483-x
https://doi.org/10.1016/s0040-4039(97)10483-x