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pro vyhledávání: '"Macrodissection"'
Akademický článek
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Autor:
Demes, Jan Jeroch, Tobias Riedlinger, Christina Schmitt, Silvana Ebner, Ria Winkelmann, Peter J. Wild, Melanie
Publikováno v:
Cancers; Volume 15; Issue 12; Pages: 3249
Currently, in routine diagnostics, most molecular testing is performed on formalin-fixed, paraffin-embedded tissue after a histomorphological assessment. In order to find the best possible and targeted individual therapy, knowing the mutational statu
Akademický článek
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Autor:
Gang Cheng, Lianju Gao, Yang Yu, Guanhua Rao, Ling Jia, Wanchun Zang, Ke Ji, Lixin Zhou, Dongmei Lin, Zhongwu Li, Dongfeng Niu, Lei Li
Publikováno v:
Pathology Oncology Research
Amplicon-based next generation sequencing (NGS) approaches have been preferentially adopted by the clinical laboratories on the basis of a short turnaround time (TAT) and small DNA input needs. However, little work has been done to assess the amplico
Publikováno v:
Technology in Cancer Research & Treatment, Vol 19 (2020)
Technology in Cancer Research & Treatment
Technology in Cancer Research & Treatment
This study aimed to compare the performance of MilliSect dissection and manual dissection. Twenty-five formalin-fixed paraffin-embedded (FFPE) breast cancer tissue blocks were selected for comparison. Specific areas of interest (AOIs) in invasive car
Publikováno v:
Journal of Clinical Pathology. 74:331-333
The determination of molecular aberrations within tumours is important for diagnostic, prognostic and predictive purposes. Pathologists play a critical role in the workflow of molecular diagnostics, by assuring accurate pathological diagnosis, reques
Autor:
Toshitaka Nagao, Jin Katayama, Jun Matsubayashi, Kazuko Sakai, Tatsuo Ohira, Norihiko Ikeda, Kazuto Nishio, Emi Iwamatsu, Akihiko Ito, Azusa Yoneshige, Tetsuya Mitsudomi
Publikováno v:
Cancer Science
Gene fusions play an important role in the carcinogenesis of lung adenocarcinoma. The recent association of four oncogenic driver genes, ALK, ROS1, RET, and NTRK1, as lung tumor predictive biomarkers has increased the need for precision medicine. We
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
Background The advent of precision oncology has led a shift towards biomarker-driven clinical trial designs and molecular profiling of individual patients. Identification of patients with the target biomarker profile may be useful in guiding patient
Autor:
Viviana Gismondi, Valerio Gaetano Vellone, Daniela Rivera, Michele Paudice, Giorgia Anselmi, Liliana Varesco
AimsNext Generation Sequencing (NGS)-based BRCA tumour tissue testing poses several challenges. As a first step of its implementation within a regional health service network, an in-house validation study was compared with published recommendations.M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4719d60a5fc953305313c1857b7d5f75
http://hdl.handle.net/11567/1020565
http://hdl.handle.net/11567/1020565
Autor:
Liesel M. FitzGerald, Neil O'Callaghan, Chol-Hee Jung, Julie K. Bassett, Ee Ming Wong, Tim Nottle, Graham G. Giles, Vivien Vasic, Jodee Gould, Jihoon E. Joo, John Pedersen, Melissa C. Southey
Publikováno v:
Laboratory Investigation. 98:537-550
Prognostic genomic biomarkers that can be measured at diagnosis to aid choice of treatment options are unavailable for most common cancers. This is due in part to the poor quality and quantity of available diagnostic specimens for discovery research