Combining explainable machine learning, demographic and multi-omic data to identify precision medicine strategies for inflammatory bowel disease

Autor: Bingham K, Laura-Jayne Gardiner, David C. Bunton, Macluskie G, Edward O. Pyzer-Knapp, McNeil M, Anna Paola Carrieri

Inflammatory bowel diseases (IBDs), including ulcerative colitis and Crohn’s disease, affect several million individuals worldwide. These diseases are heterogeneous at the clinical, immunological and genetic levels and result from a complex interac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::327288e566606963559b4f48fba4b493
https://doi.org/10.1101/2021.03.03.21252821

Application of pharmacogenomics and bioinformatics to exemplify the utility of human ex vivo organoculture models in the field of precision medicine.

Autor: Cowan K; REPROCELL Europe Ltd, Thomson Pavilion, Glasgow, Scotland, United Kingdom., Macluskie G; REPROCELL Europe Ltd, Thomson Pavilion, Glasgow, Scotland, United Kingdom., Finch M; REPROCELL Europe Ltd, Thomson Pavilion, Glasgow, Scotland, United Kingdom., Palmer CNA; School of Medicine, University of Dundee, Ninewells Hospital and Medical School, Dundee, Scotland, United Kingdom., Hair J; NHS Greater Glasgow & Clyde, Queen Elizabeth University Hospital, Glasgow, Scotland, United Kingdom., Bylesjo M; Fios Genomics Ltd, Nine Edinburgh Bioquarter, Edinburgh, Scotland, United Kingdom., Lynagh S; Fios Genomics Ltd, Nine Edinburgh Bioquarter, Edinburgh, Scotland, United Kingdom., Brankin P; Aridhia Informatics Ltd Teaching and Learning Building, Queen Elizabeth University Hospital, Glasgow, Scotland, United Kingdom., McNeil M; Stratified Medicines Scotland Innovation Centre, Teaching and Learning Building, Queen Elizabeth University Hospital, Glasgow, Scotland, United Kingdom., Low C; Stratified Medicines Scotland Innovation Centre, Teaching and Learning Building, Queen Elizabeth University Hospital, Glasgow, Scotland, United Kingdom., Mallinson D; Sistemic Ltd, West of Scotland Science Park, Glasgow, Scotland, United Kingdom., Gourlay EM; Sistemic Ltd, West of Scotland Science Park, Glasgow, Scotland, United Kingdom., Child H; Stratified Medicines Scotland Innovation Centre, Teaching and Learning Building, Queen Elizabeth University Hospital, Glasgow, Scotland, United Kingdom., Cheyne L; Stratified Medicines Scotland Innovation Centre, Teaching and Learning Building, Queen Elizabeth University Hospital, Glasgow, Scotland, United Kingdom., Bunton DC; REPROCELL Europe Ltd, Thomson Pavilion, Glasgow, Scotland, United Kingdom.

Publikováno v: PloS one [PLoS One] 2019 Dec 20; Vol. 14 (12), pp. e0226564. Date of Electronic Publication: 2019 Dec 20 (Print Publication: 2019).

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Inflammatory bowel disease genomics, transcriptomics, proteomics and metagenomics meet artificial intelligence.

Autor: Cannarozzi AL; Division of Gastroenterology and Endoscopy, Fondazione IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy., Latiano A; Division of Gastroenterology and Endoscopy, Fondazione IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy., Massimino L; Gastroenterology and Digestive Endoscopy Department, IRCCS Ospedale San Raffaele, Milan, Italy., Bossa F; Division of Gastroenterology and Endoscopy, Fondazione IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy., Giuliani F; Innovation & Research Unit, Fondazione IRCCS 'Casa Sollievo della Sofferenza', San Giovanni Rotondo, Italy., Riva M; Gastroenterology and Digestive Endoscopy Department, IRCCS Ospedale San Raffaele, Milan, Italy., Ungaro F; Gastroenterology and Digestive Endoscopy Department, IRCCS Ospedale San Raffaele, Milan, Italy., Guerra M; Division of Gastroenterology and Endoscopy, Fondazione IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy., Brina ALD; Division of Gastroenterology and Endoscopy, Fondazione IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy., Biscaglia G; Division of Gastroenterology and Endoscopy, Fondazione IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy., Tavano F; Division of Gastroenterology and Endoscopy, Fondazione IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy., Carparelli S; Division of Gastroenterology and Endoscopy, Fondazione IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy., Fiorino G; Gastroenterology and Digestive Endoscopy, San Camillo-Forlanini Hospital, Rome, Italy., Danese S; Faculty of Medicine, Università Vita-Salute San Raffaele, Milan, Italy., Perri F; Division of Gastroenterology and Endoscopy, Fondazione IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy., Palmieri O; Division of Gastroenterology and Endoscopy, Fondazione IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy.

Publikováno v: United European gastroenterology journal [United European Gastroenterol J] 2024 Dec; Vol. 12 (10), pp. 1461-1480. Date of Electronic Publication: 2024 Aug 31.

Gene Identification in Inflammatory Bowel Disease via a Machine Learning Approach.

Autor: Alfonso Perez, Gerardo, Castillo, Raquel

Publikováno v: Medicina (1010660X); Jul2023, Vol. 59 Issue 7, p1218, 15p