Activation of constitutive androstane receptor (CAR) in primary human hepatocytes

Autor: Maclennan, Richard Alexander

Human populations are at risk of exposure to constitutive androstane receptor (CAR) activators present in a range of substances, including pharmaceuticals, plasticizers and crop protection agents. What exposure to CAR activators means for human healt

Externí odkaz: http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.692757

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Corrigendum to “Development of a generic zebrafish embryo PBPK model and application to the developmental toxicity assessment of valproic acid analogs” [Reprod. Toxicol. 93 (2020) 219⬜229]

Autor: Siméon, Ségolène, Brotzmann, Katharina, Fisher, Ciarán, Gardner, Iain, Silvester, Steve, Maclennan, Richard, Walker, Paul, Braunbeck, Thomas, Bois, Frederic Y. ^*

Publikováno v: In Reproductive Toxicology December 2020 98:300-303

PBPK modeling of zebrafish embryo for reprotoxicity assessment of valproic acid and some of its analogs

Autor: Simeon, Ségolène, Brotzmann, Katharina, Fischer, C., Gardner, I., Braunbeck, Thomas, Silvester, S., Maclennan, Richard, Bois, Frédéric Y.

Publikováno v: Abstracts book of the ECOPA 2018 Symposium "How new experimental tools in life sciences challenge the 3Rs vision"
ECOPA 2018 Symposium "How new experimental tools in life sciences challenge the 3Rs vision"
ECOPA 2018 Symposium "How new experimental tools in life sciences challenge the 3Rs vision", Nov 2018, Paris, France. pp.52

Introduction: Understanding and predicting chemical effects on development and reproduction is a complex challenge. The zebrafish embryo is an in vitro test system increasingly used for its transparency, short development time, easy husbandry and gen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::2d0026eef88c4bff782346f4d721c87d
https://hal-ineris.archives-ouvertes.fr/ineris-03239687

EU-ToxRisk - Prediction of microvesicular liver steatosis : read across case study with VPA and analogues

Autor: Grapel, Rabea, Tluczkiewicz, Inga, Abdelaziz, Ahmed, van Vugt, Barbara, Fisher, Ciaran, Hatley, Oliver, Pawar, Gopal, Zdrazil, Barbara, Jain, Sankalp, Bois, Frédéric Y., Tolosa, Laia, Jennings, Paul, Limonciel, Alice, Stober, Regina, Maclennan, Richard, Exner, Thomas, Lindberg, Johann, Brotzmann, Katharina, Braunbeck, Thomas, Norinder, Ulf, Taboreau, Olivier, Drewe, Will, Long, Tony, Aguayo, Alejandro, Bischoff, Luc, Hengstler, Jan, Escher, Sylvia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::34936346abe0a5d38a78ec757cf32b42
https://hal-ineris.archives-ouvertes.fr/ineris-01853098