Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Macklin Brian Arnold"'
Autor:
Qing Shi, Christopher W. Doecke, Emily Jane Canada, John M. Zgombick, Timothy Ivo Richardson, Paul L. Ornstein, Michael J. Martinelli, Hansen M. Hsiung, Matt R. Reinhard, Jennifer L. Buckmaster, Chaoyu Xie, Roger Ryan Rothhaar, Larry Wayne Hertel, Zhipei Wu, Steve L. Kuklish, Karin Briner, Jikesh Arvind Shah, Saba Husain, Thomas P. O’Brien, Nick Honigschmidt, Macklin Brian Arnold, Ryan Thomas Backer, Jeffrey T. Mullaney, Matthew J. Fisher
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:2341-2346
A series of benzylic piperazines (e.g., 4 and 5) attached to an 'address element', the dipeptide H-D-Tic-D-p-Cl-Phe-OH, 3 has been identified as ligands for the melanocortin subtype-4 receptor (MC4R). We describe herein the structure-activity relatio
Autor:
D D Schoepp, Thomas J. Bleisch, Bryan G. Johnson, Rebecca A. Wright, Paul L. Ornstein, Macklin Brian Arnold
Publikováno v:
Journal of Medicinal Chemistry. 41:346-357
In this paper, we describe the synthesis of a series of alpha-substituted analogues of the potent and selective group II metabotropic glutamate receptor (mGluR) agonist (1S,1'S,2'S)-carboxycyclopropylglycine (2, L-CCG 1). Incorporation of a substitue
Autor:
Macklin Brian Arnold, Paul L. Ornstein, D D Schoepp, J. D. Leander, Charles Willis Lugar, Peter Stanley Borromeo, David Lodge, N. K. Allen, Thomas J. Bleisch
Publikováno v:
Journal of Medicinal Chemistry. 39:2219-2231
A series of 6-substituted decahydroisoquinoline-3-carboxylic acids were prepared as excitatory amino acid (EAA) receptor antagonists. These compounds are antagonists at the N-methyl-D-aspartate (NMDA) and 2-amino-3-(5-methyl-3-hydroxyisoxazol-4-yl) p
Autor:
Paul L. Ornstein, David Lodge, Macklin Brian Arnold, Darryle Darwin Schoepp, Joseph P. Tizzano, N. K. Allen, J. D. Leander
Publikováno v:
Journal of Medicinal Chemistry. 38:4885-4890
We report the synthesis and characterization of 6 (LY246492), which is a competitive N-methyl-D-aspartate (NMDA) and 2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propanoic acid (AMPA) receptor antagonist. Tetrazole-substituted amino acid 6 was prepared
Autor:
David Lodge, Darryle Darwin Schoepp, Paul L. Ornstein, Macklin Brian Arnold, J. D. Leander, T. Elzey, Jonathan W. Paschal
Publikováno v:
ChemInform. 22
We have prepared a series of cis-4-(tetrazolylakyl)piperidine-2-carboxylic acids as potent and selective N-methyl-D-aspartic acid (NMDA) receptor antagonists. NMDA antagonists may prove to be useful therapeutic agents, for instance, as anticonvulsant
Publikováno v:
ChemInform. 22
Autor:
David Lodge, Macklin Brian Arnold, Joseph P. Tizzano, J. D. Leander, Paul L. Ornstein, Darryle Darwin Schoepp, N. K. Allen
Publikováno v:
ChemInform. 27
We report the synthesis and characterization of 6 (LY246492), which is a competitive N-methyl-D-aspartate (NMDA) and 2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propanoic acid (AMPA) receptor antagonist. Tetrazole-substituted amino acid 6 was prepared
Autor:
David Lodge, Macklin Brian Arnold, Thomas J. Bleisch, N. K. Allen, P. L. Ornstein, D D Schoepp, Peter Stanley Borromeo, J. D. Leander, Charles Willis Lugar
Publikováno v:
ChemInform. 27
Autor:
William Henry Walker Lunn, Paul L. Ornstein, D D Schoepp, L. J. Heinz, David Lodge, J. D. Leander, Macklin Brian Arnold
Publikováno v:
ChemInform. 29
Autor:
Jack B. Campbell, John D. Millar, Nancy K. Augenstein, D. M. Zimmerman, Macklin Brian Arnold, Paul L. Ornstein, J. W. Chambers, Jonathan W. Paschal, D D Schoepp, David M. Lodge
Publikováno v:
Journal of Medicinal Chemistry. 35:3547-3560
We have prepared a series of 6-substituted decahydroisoquinoline-3-carboxylic acids, and structurally similar analogs, as potential N-methyl-D-aspartate receptor antagonists. There is a large body of evidence to support the use of such compounds as c