Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Macklin, PS"'
Publikováno v:
Nature Communications. 13
Regulatory B cells (Breg) are a heterogenous population with immune-modulating functions. The rarity of human IL-10+ Breg makes translational studies difficult. Here we report ex vivo expansion of human B cells with in vivo regulatory function (expBr
Autor:
Yamamoto, A, Hester, J, Macklin, PS, Kawai, K, Uchiyama, M, Biggs, D, Bishop, T, Bull, K, Cheng, X, Cawthorne, E, Coleman, ML, Crockford, TL, Davies, B, Dow, LE, Goldin, R, Kranc, K, Kudo, H, Lawson, H, McAuliffe, J, Milward, K, Scudamore, CL, Soilleux, E, Issa, F, Ratcliffe, PJ, Pugh, CW
Publikováno v:
Journal of Clinical Investigation. 129(9)
Physiological effects of cellular hypoxia are sensed by prolyl hydroxylase (PHD) enzymes which regulate HIFs. Genetic interventions on HIF/PHD pathways reveal multiple phenotypes that extend the known biology of hypoxia. Recent studies unexpectedly i
Autor:
Barnkob MB; MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Headley Way, Oxford, OX3 9DS, UK. mike.bogetofte.barnkob@rsyd.dk.; Centre for Cellular Immunotherapy of Haematological Cancer Odense (CITCO), Department of Clinical Immunology, Odense University Hospital, University of Southern Denmark, Odense, Denmark. mike.bogetofte.barnkob@rsyd.dk., Michaels YS; MRC Weatherall Institute of Molecular Medicine, University of Oxford, Headley Way, Oxford, OX3 9DS, UK.; Paul Albrechtsen Research Institute, CancerCare Manitoba, 675 Mcdermot Ave, Winnipeg, MB, R3E 0V9, Canada.; Department of Biochemistry and Medical Genetics, Rady Faculty of Health Sciences, University of Manitoba, Bannatyne Ave, Winnipeg, MB, R3E 3N4, Canada., André V; MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Headley Way, Oxford, OX3 9DS, UK., Macklin PS; Nuffield Department of Medicine, University of Oxford, Nuffield Department of Medicine Research Building, Roosevelt Drive, Oxford, OX3 7FZ, UK., Gileadi U; MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Headley Way, Oxford, OX3 9DS, UK., Valvo S; Kennedy Institute of Rheumatology, University of Oxford, Roosevelt Dr, Oxford, OX3 7FY, UK., Rei M; MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Headley Way, Oxford, OX3 9DS, UK.; Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal., Kulicke C; MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Headley Way, Oxford, OX3 9DS, UK.; Pulmonary and Critical Care Medicine, Oregon Health and Science University, Portland, OR, US., Chen JL; MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Headley Way, Oxford, OX3 9DS, UK., Jain V; Division of Structural Biology, Wellcome Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, OX3 7BN, UK., Woodcock VK; MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Headley Way, Oxford, OX3 9DS, UK., Colin-York H; MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Headley Way, Oxford, OX3 9DS, UK., Hadjinicolaou AV; MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Headley Way, Oxford, OX3 9DS, UK.; Division of Gastroenterology & Hepatology, Department of Medicine, Cambridge University Hospitals, University of Cambridge, Cambridge, England.; Early Cancer Institute, Department of Oncology, University of Cambridge, Cambridge, England., Kong Y; Division of Structural Biology, Wellcome Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, OX3 7BN, UK., Mayya V; Kennedy Institute of Rheumatology, University of Oxford, Roosevelt Dr, Oxford, OX3 7FY, UK., Mazet JM; Kennedy Institute of Rheumatology, University of Oxford, Roosevelt Dr, Oxford, OX3 7FY, UK., Mead GJ; Kennedy Institute of Rheumatology, University of Oxford, Roosevelt Dr, Oxford, OX3 7FY, UK., Bull JA; Wolfson Centre for Mathematical Biology, Mathematical Institute, University of Oxford, Radcliffe Observatory Quarter, Woodstock Road, Oxford, OX2 6GG, UK., Rijal P; MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Headley Way, Oxford, OX3 9DS, UK., Pugh CW; Nuffield Department of Medicine, University of Oxford, Nuffield Department of Medicine Research Building, Roosevelt Drive, Oxford, OX3 7FZ, UK., Townsend AR; MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Headley Way, Oxford, OX3 9DS, UK., Gérard A; Kennedy Institute of Rheumatology, University of Oxford, Roosevelt Dr, Oxford, OX3 7FY, UK., Olsen LR; Department of Health Technology, Technical University of Denmark, Ørsteds Plads, Building 345C, 2800 Kgs, Lyngby, Denmark., Fritzsche M; MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Headley Way, Oxford, OX3 9DS, UK.; Kennedy Institute of Rheumatology, University of Oxford, Roosevelt Dr, Oxford, OX3 7FY, UK., Fulga TA; MRC Weatherall Institute of Molecular Medicine, University of Oxford, Headley Way, Oxford, OX3 9DS, UK., Dustin ML; Kennedy Institute of Rheumatology, University of Oxford, Roosevelt Dr, Oxford, OX3 7FY, UK., Jones EY; Division of Structural Biology, Wellcome Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, OX3 7BN, UK. yvonne@strubi.ox.ac.uk., Cerundolo V; MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Headley Way, Oxford, OX3 9DS, UK.
Publikováno v:
Nature communications [Nat Commun] 2024 Apr 24; Vol. 15 (1), pp. 3448. Date of Electronic Publication: 2024 Apr 24.
Autor:
Barnkob MB; MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Headley Way, Oxford, OX3 9DS, UK. mike.bogetofte.barnkob@rsyd.dk.; Centre for Cellular Immunotherapy of Haematological Cancer Odense (CITCO), Department of Clinical Immunology, Odense University Hospital, University of Southern Denmark, Odense, Denmark. mike.bogetofte.barnkob@rsyd.dk., Michaels YS; MRC Weatherall Institute of Molecular Medicine, University of Oxford, Headley Way, Oxford, OX3 9DS, UK.; Paul Albrechtsen Research Institute, CancerCare Manitoba, 675 Mcdermot Ave, Winnipeg, MB, R3E 0V9, Canada.; Department of Biochemistry and Medical Genetics, Rady Faculty of Health Sciences, University of Manitoba, Bannatyne Ave, Winnipeg, MB, R3E 3N4, Canada., André V; MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Headley Way, Oxford, OX3 9DS, UK., Macklin PS; Nuffield Department of Medicine, University of Oxford, Nuffield Department of Medicine Research Building, Roosevelt Drive, Oxford, OX3 7FZ, UK., Gileadi U; MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Headley Way, Oxford, OX3 9DS, UK., Valvo S; Kennedy Institute of Rheumatology, University of Oxford, Roosevelt Dr, Oxford, OX3 7FY, UK., Rei M; MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Headley Way, Oxford, OX3 9DS, UK.; Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal., Kulicke C; MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Headley Way, Oxford, OX3 9DS, UK.; Pulmonary and Critical Care Medicine, Oregon Health and Science University, Portland, OR, US., Chen JL; MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Headley Way, Oxford, OX3 9DS, UK., Jain V; Division of Structural Biology, Wellcome Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, OX3 7BN, UK., Woodcock VK; MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Headley Way, Oxford, OX3 9DS, UK., Colin-York H; MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Headley Way, Oxford, OX3 9DS, UK., Hadjinicolaou AV; MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Headley Way, Oxford, OX3 9DS, UK.; Division of Gastroenterology & Hepatology, Department of Medicine, Cambridge University Hospitals, University of Cambridge, Cambridge, England.; Early Cancer Institute, Department of Oncology, University of Cambridge, Cambridge, England., Kong Y; Division of Structural Biology, Wellcome Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, OX3 7BN, UK., Mayya V; Kennedy Institute of Rheumatology, University of Oxford, Roosevelt Dr, Oxford, OX3 7FY, UK., Mazet JM; Kennedy Institute of Rheumatology, University of Oxford, Roosevelt Dr, Oxford, OX3 7FY, UK., Mead GJ; Kennedy Institute of Rheumatology, University of Oxford, Roosevelt Dr, Oxford, OX3 7FY, UK., Bull JA; Wolfson Centre for Mathematical Biology, Mathematical Institute, University of Oxford, Radcliffe Observatory Quarter, Woodstock Road, Oxford, OX2 6GG, UK., Rijal P; MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Headley Way, Oxford, OX3 9DS, UK., Pugh CW; Nuffield Department of Medicine, University of Oxford, Nuffield Department of Medicine Research Building, Roosevelt Drive, Oxford, OX3 7FZ, UK., Townsend AR; MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Headley Way, Oxford, OX3 9DS, UK., Gérard A; Kennedy Institute of Rheumatology, University of Oxford, Roosevelt Dr, Oxford, OX3 7FY, UK., Olsen LR; Department of Health Technology, Technical University of Denmark, Ørsteds Plads, Building 345C, 2800 Kgs, Lyngby, Denmark., Fritzsche M; MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Headley Way, Oxford, OX3 9DS, UK.; Kennedy Institute of Rheumatology, University of Oxford, Roosevelt Dr, Oxford, OX3 7FY, UK., Fulga TA; MRC Weatherall Institute of Molecular Medicine, University of Oxford, Headley Way, Oxford, OX3 9DS, UK., Dustin ML; Kennedy Institute of Rheumatology, University of Oxford, Roosevelt Dr, Oxford, OX3 7FY, UK., Jones EY; Division of Structural Biology, Wellcome Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford, OX3 7BN, UK. yvonne@strubi.ox.ac.uk., Cerundolo V; MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford, Headley Way, Oxford, OX3 9DS, UK.
Publikováno v:
Nature communications [Nat Commun] 2024 Apr 12; Vol. 15 (1), pp. 3173. Date of Electronic Publication: 2024 Apr 12.
Autor:
Macklin PS; Doctor, Department of Cellular Pathology, Oxford University Hospitals, NHS Foundation Trust, Oxford, Oxfordshire, United Kingdom., Fisher R; Doctor, Department of Dermatology, Royal Berkshire, NHS Foundation Trust, Reading, Berkshire, United Kingdom; and., Stonard C; Doctor, Department of Cellular Pathology, Oxford University Hospitals, NHS Foundation Trust, Oxford, Oxfordshire, United Kingdom., Matin RN; Doctor, Department of Dermatology, Oxford University Hospitals, NHS Foundation Trust, Oxford, Oxfordshire, United Kingdom., Ieremia E; Doctor, Department of Cellular Pathology, Oxford University Hospitals, NHS Foundation Trust, Oxford, Oxfordshire, United Kingdom.
Publikováno v:
The American Journal of dermatopathology [Am J Dermatopathol] 2023 Aug 01; Vol. 45 (8), pp. 519-531.
Autor:
Shankar S; Translational Research and Immunology Group, Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK. sushma.shankar@nds.ox.ac.uk.; Oxford Transplant Centre, Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK. sushma.shankar@nds.ox.ac.uk., Stolp J; Translational Research and Immunology Group, Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK., Juvet SC; Translational Research and Immunology Group, Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK., Beckett J; Translational Research and Immunology Group, Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK., Macklin PS; Nuffield Department of Medicine Research Building, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Issa F; Translational Research and Immunology Group, Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK., Hester J; Translational Research and Immunology Group, Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK., Wood KJ; Translational Research and Immunology Group, Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK. kathryn.wood@nds.ox.ac.uk.
Publikováno v:
Nature communications [Nat Commun] 2022 Jun 03; Vol. 13 (1), pp. 3121. Date of Electronic Publication: 2022 Jun 03.
Autor:
Vipond O; Mathematical Institute, University of Oxford, Oxford OX2 6GG, United Kingdom., Bull JA; Mathematical Institute, University of Oxford, Oxford OX2 6GG, United Kingdom., Macklin PS; Nuffield Department of Medicine Research Building, University of Oxford, Oxford OX3 7FZ, United Kingdom., Tillmann U; Mathematical Institute, University of Oxford, Oxford OX2 6GG, United Kingdom; ulrike.tillmann@maths.ox.ac.uk chris.pugh@ndm.ox.ac.uk byrneh@maths.ox.ac.uk harrington@maths.ox.ac.uk., Pugh CW; Nuffield Department of Medicine Research Building, University of Oxford, Oxford OX3 7FZ, United Kingdom; ulrike.tillmann@maths.ox.ac.uk chris.pugh@ndm.ox.ac.uk byrneh@maths.ox.ac.uk harrington@maths.ox.ac.uk., Byrne HM; Mathematical Institute, University of Oxford, Oxford OX2 6GG, United Kingdom; ulrike.tillmann@maths.ox.ac.uk chris.pugh@ndm.ox.ac.uk byrneh@maths.ox.ac.uk harrington@maths.ox.ac.uk., Harrington HA; Mathematical Institute, University of Oxford, Oxford OX2 6GG, United Kingdom; ulrike.tillmann@maths.ox.ac.uk chris.pugh@ndm.ox.ac.uk byrneh@maths.ox.ac.uk harrington@maths.ox.ac.uk.; Wellcome Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, United Kingdom.
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2021 Oct 12; Vol. 118 (41).
Autor:
Skwarski M; Department of Oncology, University of Oxford, Oxford, England, United Kingdom.; Department of Oncology, Oxford University Hospitals National Health Service Foundation Trust, Oxford, England, United Kingdom., McGowan DR; Department of Oncology, University of Oxford, Oxford, England, United Kingdom.; Radiation Physics and Protection, Oxford University Hospitals National Health Service Foundation Trust, Oxford, England, United Kingdom., Belcher E; Department of Cardiothoracic Surgery, Oxford University Hospitals National Health Service Foundation Trust, Oxford, England, United Kingdom., Di Chiara F; Department of Cardiothoracic Surgery, Oxford University Hospitals National Health Service Foundation Trust, Oxford, England, United Kingdom., Stavroulias D; Department of Cardiothoracic Surgery, Oxford University Hospitals National Health Service Foundation Trust, Oxford, England, United Kingdom., McCole M; Department of Cellular Pathology, Oxford University Hospitals National Health Service Foundation Trust, Oxford, England, United Kingdom., Derham JL; Department of Oncology, Oxford University Hospitals National Health Service Foundation Trust, Oxford, England, United Kingdom., Chu KY; Department of Oncology, University of Oxford, Oxford, England, United Kingdom.; Department of Oncology, Oxford University Hospitals National Health Service Foundation Trust, Oxford, England, United Kingdom., Teoh E; Department of Oncology, Oxford University Hospitals National Health Service Foundation Trust, Oxford, England, United Kingdom., Chauhan J; Ludwig Institute for Cancer Research Oxford, University of Oxford, Oxford, England, United Kingdom., O'Reilly D; Department of Oncology, University of Oxford, Oxford, England, United Kingdom., Harris BHL; Department of Oncology, University of Oxford, Oxford, England, United Kingdom., Macklin PS; Nuffield Department of Medicine, University of Oxford, Oxford, England, United Kingdom., Bull JA; Wolfson Centre for Mathematical Biology, University of Oxford, Oxford, England, United Kingdom., Green M; Department of Oncology, University of Oxford, Oxford, England, United Kingdom., Rodriguez-Berriguete G; Department of Oncology, University of Oxford, Oxford, England, United Kingdom., Prevo R; Department of Oncology, University of Oxford, Oxford, England, United Kingdom., Folkes LK; Department of Oncology, University of Oxford, Oxford, England, United Kingdom., Campo L; Department of Oncology, University of Oxford, Oxford, England, United Kingdom., Ferencz P; Institute of Biomedical Engineering, University of Oxford, Oxford, England, United Kingdom., Croal PL; Institute of Biomedical Engineering, University of Oxford, Oxford, England, United Kingdom., Flight H; Oncology Clinical Trials Office, Department of Oncology, University of Oxford, Oxford, England, United Kingdom., Qi C; Centre for Statistics in Medicine, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, England, United Kingdom., Holmes J; Centre for Statistics in Medicine, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, England, United Kingdom., O'Connor JPB; Division of Cancer Sciences, University of Manchester, Manchester, England, United Kingdom., Gleeson FV; Department of Radiology, Oxford University Hospitals National Health Service Foundation Trust, Oxford, England, United Kingdom., McKenna WG; Department of Oncology, University of Oxford, Oxford, England, United Kingdom., Harris AL; Department of Oncology, University of Oxford, Oxford, England, United Kingdom., Bulte D; Institute of Biomedical Engineering, University of Oxford, Oxford, England, United Kingdom., Buffa FM; Department of Oncology, University of Oxford, Oxford, England, United Kingdom., Macpherson RE; Department of Radiology, Oxford University Hospitals National Health Service Foundation Trust, Oxford, England, United Kingdom., Higgins GS; Department of Oncology, University of Oxford, Oxford, England, United Kingdom. geoffrey.higgins@oncology.ox.ac.uk.; Department of Oncology, Oxford University Hospitals National Health Service Foundation Trust, Oxford, England, United Kingdom.
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2021 May 01; Vol. 27 (9), pp. 2459-2469. Date of Electronic Publication: 2021 Feb 17.
Autor:
Bull JA; Wolfson Centre for Mathematical Biology, Mathematical Institute, University of Oxford, Oxford, OX2 6GG, UK. joshua.bull@maths.ox.ac.uk., Macklin PS; Nuffield Department of Medicine, NDM Research Building, University of Oxford, Oxford, OX3 7FZ, UK., Quaiser T; Roche Pharma Research and Early Development, pRED Informatics, Roche Innovation Center Munich, Munich, Germany., Braun F; Roche Pharma Research and Early Development, pRED Informatics, Roche Innovation Center Munich, Munich, Germany., Waters SL; Oxford Centre for Industrial and Applied Mathematics, Mathematical Institute, University of Oxford, Oxford, OX2 6GG, UK., Pugh CW; Nuffield Department of Medicine, NDM Research Building, University of Oxford, Oxford, OX3 7FZ, UK., Byrne HM; Wolfson Centre for Mathematical Biology, Mathematical Institute, University of Oxford, Oxford, OX2 6GG, UK.
Publikováno v:
Scientific reports [Sci Rep] 2020 Oct 29; Vol. 10 (1), pp. 18624. Date of Electronic Publication: 2020 Oct 29.
Autor:
Macklin PS; Department of Cellular Pathology, John Radcliffe Hospital, Oxford, UK., Verrill CL; Department of Cellular Pathology, John Radcliffe Hospital, Oxford, UK.; Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK.; National Institute for Health Research (NIHR), Oxford Biomedical Research Centre (BRC), Oxford, UK., Roberts ISD; Department of Cellular Pathology, John Radcliffe Hospital, Oxford, UK., Colling R; Department of Cellular Pathology, John Radcliffe Hospital, Oxford, UK.; Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK., Sullivan ME; Department of Urology, Churchill Hospital, Oxford, UK., Webster GM; Department of Urology, Churchill Hospital, Oxford, UK., Cranston DW; Department of Urology, Churchill Hospital, Oxford, UK., Tapping CR; Department of Radiology, John Radcliffe Hospital, Oxford, UK., Browning L; Department of Cellular Pathology, John Radcliffe Hospital, Oxford, UK.; National Institute for Health Research (NIHR), Oxford Biomedical Research Centre (BRC), Oxford, UK.
Publikováno v:
Histopathology [Histopathology] 2020 Apr; Vol. 76 (5), pp. 763-766. Date of Electronic Publication: 2020 Mar 24.