Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Mackenzie Welch"'
Autor:
Swetha Mohan, Paul J. Sampognaro, Andrea R. Argouarch, Jason C. Maynard, Mackenzie Welch, Anand Patwardhan, Emma C. Courtney, Jiasheng Zhang, Amanda Mason, Kathy H. Li, Eric J. Huang, William W. Seeley, Bruce L. Miller, Alma Burlingame, Mathew P. Jacobson, Aimee W. Kao
Publikováno v:
Molecular Neurodegeneration, Vol 16, Iss 1, Pp 1-18 (2021)
Abstract Background Progranulin loss-of-function mutations are linked to frontotemporal lobar degeneration with TDP-43 positive inclusions (FTLD-TDP-Pgrn). Progranulin (PGRN) is an intracellular and secreted pro-protein that is proteolytically cleave
Externí odkaz:
https://doaj.org/article/2bcbf5d1642d41eea3c3e628a2a7b9be
Autor:
Tracy A. Cole, Hien Zhao, Timothy J. Collier, Ivette Sandoval, Caryl E. Sortwell, Kathy Steece-Collier, Brian F. Daley, Alix Booms, Jack Lipton, Mackenzie Welch, Melissa Berman, Luke Jandreski, Danielle Graham, Andreas Weihofen, Stephanie Celano, Emily Schulz, Allyson Cole-Strauss, Esteban Luna, Duc Quach, Apoorva Mohan, C. Frank Bennett, Eric E. Swayze, Holly B. Kordasiewicz, Kelvin C. Luk, Katrina L. Paumier
Publikováno v:
JCI Insight, Vol 6, Iss 5 (2021)
Parkinson’s disease (PD) is a prevalent neurodegenerative disease with no approved disease-modifying therapies. Multiplications, mutations, and single nucleotide polymorphisms in the SNCA gene, encoding α-synuclein (aSyn) protein, either cause or
Externí odkaz:
https://doaj.org/article/d06ea6f3c76f4b97a20be199ac938389
Autor:
Srividya Sundararaman, Alexey Y. Karulin, Tameem Ansari, Nadine BenHamouda, Judith Gottwein, Sreenivas Laxmanan, Steven M. Levine, John T. Loffredo, Stephanie McArdle, Christine Neudoerfl, Diana Roen, Karina Silina, Mackenzie Welch, Paul V. Lehmann
Publikováno v:
Cells, Vol 4, Iss 1, Pp 21-39 (2015)
The primary goal of immune monitoring with ELISPOT is to measure the number of T cells, specific for any antigen, accurately and reproducibly between different laboratories. In ELISPOT assays, antigen-specific T cells secrete cytokines, forming spots
Externí odkaz:
https://doaj.org/article/4b8b577842b84291b39e2adf1401c336
Autor:
Aimee W. Kao, Austin L Wang, Anand Patwardhan, Michael Grabe, Phi T. Nguyen, Kean-Hooi Ang, Anna V. Molofsky, Carolina Alquezar, Michelle R. Arkin, Marcus Y. Chin, Mackenzie Welch
Publikováno v:
ACS Sensors
ACS sensors, vol 6, iss 6
ACS sensors, vol 6, iss 6
Lysosomes are important sites for macromolecular degradation, defined by an acidic lumenal pH of ∼4.5. To better understand lysosomal pH, we designed a novel, genetically encoded, fluorescent protein (FP)-based pH biosensor called Fluorescence Indi
Autor:
Jason Aldred, Natalia Penner, Pepinsky R Blake, Ira J. Goodman, Erica Koenig, Shavy Makh, Laura Fanning, Serena Hung, Andreas Weihofen, YuTing Liu, Minhua Yang, Danielle Graham, Eric David, Mackenzie Welch, Jesse M. Cedarbaum, Miroslaw Brys, Aaron Ellenbogen, Tara Fox
Publikováno v:
Movement Disorders
Background Pathological and genetic evidence implicates toxic effects of aggregated α‐synuclein in the pathophysiology of neuronal dysfunction and degeneration in Parkinson's disease. Immunotherapy targeting aggregated α‐synuclein is a promisin
Autor:
Duc Quach, Timothy J. Collier, Andreas Weihofen, Holly Kordasiewicz, Melissa Berman, Esteban Luna, Hien T Zhao, Apoorva Mohan, Ivette M. Sandoval, Stephanie L. Celano, Alix Booms, Brian F. Daley, Emily Schulz, Tracy Cole, Luke Jandreski, Kathy Steece-Collier, Katrina L. Paumier, Kelvin C. Luk, Danielle Graham, Jack W. Lipton, C. Frank Bennett, Allyson Cole-Strauss, Caryl E. Sortwell, Mackenzie Welch, Eric E. Swayze
Publikováno v:
JCI Insight
JCI Insight, Vol 6, Iss 5 (2021)
JCI Insight, Vol 6, Iss 5 (2021)
Parkinson’s disease (PD) is a prevalent neurodegenerative disease with no approved disease-modifying therapies. Multiplications, mutations, and single nucleotide polymorphisms in the SNCA gene, encoding α-synuclein (aSyn) protein, either cause or
Autor:
Anand Patwardhan, Swetha Mohan, Andrea R. Argouarch, Eric J. Huang, William W. Seeley, Jason C. Maynard, Alma L. Burlingame, Jiasheng Zhang, Bruce L. Miller, Mackenzie Welch, Kathy H. Li, Amanda R. Mason, Mathew P Jacobson, Emma C Courtney, Aimee W. Kao, Paul J. Sampognaro
Publikováno v:
Molecular Neurodegeneration
Molecular neurodegeneration, vol 16, iss 1
Molecular Neurodegeneration, Vol 16, Iss 1, Pp 1-18 (2021)
Molecular neurodegeneration, vol 16, iss 1
Molecular Neurodegeneration, Vol 16, Iss 1, Pp 1-18 (2021)
Background Progranulin loss-of-function mutations are linked to frontotemporal lobar degeneration with TDP-43 positive inclusions (FTLD-TDP-Pgrn). Progranulin (PGRN) is an intracellular and secreted pro-protein that is proteolytically cleaved into in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d516d0c2aa3f4901695e18220416d08
https://doi.org/10.21203/rs.3.rs-44128/v3
https://doi.org/10.21203/rs.3.rs-44128/v3
Autor:
Tracy Cole, Duc Quach, C. Frank Bennett, Stephanie L. Celano, Emily Schulz, Luke Jandreski, Melissa Berman, Caryl E. Sortwell, Holly B. Kordasiewicz, Andreas Weihofen, Alix Booms, Timothy J. Collier, Mackenzie Welch, Allyson Cole-Strauss, Eric E. Swayze, Kelvin C. Luk, Apoorva Mohan, Katrina L. Paumier, Danielle Graham, Jack W. Lipton, Kathy Steece-Collier, Esteban Luna, Ivette M. Sandoval, Hien T Zhao, Brian F. Daley
Parkinson’s disease (PD) is a prevalent neurodegenerative disease with no approved disease-modifying therapies. Multiplications, mutations, and single nucleotide polymorphisms in the SNCA gene, encoding alpha-synuclein protein (aSyn), either cause
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dca9a4dde9665efc7437571a0a7b9ce
Autor:
Nadine Benhamouda, Christine Neudoerfl, Judith M. Gottwein, Srividya Sundararaman, Steven Levine, Alexey Y. Karulin, Paul V. Lehmann, Sreenivas Laxmanan, Stephanie E. B. McArdle, Mackenzie Welch, Karina Silina, Diana R. Roen, Tameem Ansari, John T. Loffredo
Publikováno v:
Cells
Volume 4
Issue 1
Pages 21-39
Cells, Vol 4, Iss 1, Pp 21-39 (2015)
Volume 4
Issue 1
Pages 21-39
Cells, Vol 4, Iss 1, Pp 21-39 (2015)
The primary goal of immune monitoring with ELISPOT is to measure the number of T cells, specific for any antigen, accurately and reproducibly between different laboratories. In ELISPOT assays, antigen-specific T cells secrete cytokines, forming spots
Autor:
Jinho Kim, Mackenzie Welch, Robert J. Ferrante, Emmanuel Brouillet, Noelle Dufour, Philippe Hantraye, Nicole Déglon, Richard Gilmore, Gilles Bonvento, Mathilde Faideau, Kerry Cormier, Martine Guillermier, Gwennaelle Auregan
Publikováno v:
Human Molecular Genetics; Vol 19
Human Molecular Genetics
Human Molecular Genetics
Huntington's disease (HD) is a neurodegenerative disorder previously thought to be of primary neuronal origin, despite ubiquitous expression of mutant huntingtin (mHtt). We tested the hypothesis that mHtt expressed in astrocytes may contribute to the