Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Mackenzie Heck"'
Autor:
Anna Hoefges, Sean J. McIlwain, Amy K. Erbe, Nicholas Mathers, Angie Xu, Drew Melby, Kaitlin Tetreault, Trang Le, Kyungmann Kim, Richard S. Pinapati, Bradley H. Garcia, Jigar Patel, Mackenzie Heck, Arika S. Feils, Noah Tsarovsky, Jacquelyn Ann Hank, Zachary Scott Morris, Irene M. Ong, Paul Mark Sondel
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Sera of immune mice that were previously cured of their melanoma through a combined radiation and immunocytokine immunotherapy regimen consisting of 12 Gy of external beam radiation and the intratumoral administration of an immunocytokine (anti-GD2 m
Externí odkaz:
https://doaj.org/article/8466ead366ce453eadbdb62f4e1bdc90
Autor:
Noah Tsarovsky, Mildred Felder, Mackenzie Heck, Jacob Slowinski, Kayla Rasmussen, Sabrina VandenHeuvel, Jen Zaborek, Zachary S. Morris, Amy K. Erbe, Paul M. Sondel, Alexander L. Rakhmilevich
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
IntroductionWe have previously shown that an intratumoral (IT) injection of the hu14.18-IL2 immunocytokine (IC), an anti-GD2 antibody linked to interleukin 2, can serve as an in situ vaccine and synergize with local radiotherapy (RT) to induce T cell
Externí odkaz:
https://doaj.org/article/31fc084eb860409982966059be52b354
Autor:
Paul Sondel, Alexander Rakhmilevich, Mildred Felder, Zachary Morris, Amy Erbe, Mackenzie Heck, Noah Tsarovsky, Jacob Slowinski, Kayla Rasmussen, Sabrina VandenHeuvel
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
Externí odkaz:
https://doaj.org/article/1435c8d8deb44fa4bb6db9f8c7677292
Autor:
Paul Sondel, Alexander Rakhmilevich, Anna Hoefges, Zachary Morris, Amy Erbe, Arika Feils, Mackenzie Heck, Peter Carlson, Luke Zangl, Ravi Patel, Dmitriy Kravtsov, Jacquelyn Hank
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
Externí odkaz:
https://doaj.org/article/a8d93b52b7f244b099db6bb173331859
Autor:
Amy K. Erbe, Arika S. Feils, Alina Hampton, Dan Spiegelman, Noah Tsarovsky, Anna Hoefges, Peter M. Carlson, Alex Pieper, Callie Haertle, Mackenzie Heck, Sabrina VandenHeuvel, Lizzie Frankel, Lauren Zebertavage, Alexa Heaton, Zachary S. Morris, Ravi Patel, Alexander Rakhmilevich, Paul M. Sondel
Publikováno v:
Cancer Research. 83:4142-4142
Using an in situ vaccine (ISV) regimen that includes a combination therapy of radiation (given at D0) with hu14.18-IL2 immunocytokine [anti-GD2 linked to IL2, (Anyxis Immuno-Oncology GmbH (Austria)); given at D5-D9], we can cure mice of large B78 mel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f01d6feef907ffe6fe15658b38cba848
https://doi.org/10.1158/1538-7445.am2023-4142
https://doi.org/10.1158/1538-7445.am2023-4142
Autor:
Mackenzie Heck, Zachary S. Morris, Mildred Felder, Paul M. Sondel, Amy K. Erbe, Sabrina VandenHeuvel, Jacob Slowinski, Noah W. Tsarovsky, Kayla Rasmussen, Alexander L. Rakhmilevich
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
BackgroundWe have previously shown that a direct intratumoral (IT) injection of the hu14.18-IL2 immunocytokine (IC), an anti-GD2 antibody linked to interleukin 2, can serve as an in situ vaccine and synergize with local radiotherapy (RT) to induce T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f8334a3b7459ba1cf9f269c1853a5eb
https://doaj.org/article/1435c8d8deb44fa4bb6db9f8c7677292
https://doaj.org/article/1435c8d8deb44fa4bb6db9f8c7677292
Autor:
Amy K. Erbe, Arika Feils, Mackenzie Heck, Sabrina VandenHeuvel, Julianna Castillo, Alina Hampton, Lizzie Frankel, Anna Hoefges, Peter Carlson, Alex A. Pieper, Taylor Aiken, Lauren Zebertavage, David Komjathy, Dan Spiegelman, Noah Tsarovsky, Zachary S. Morris, Ravi Patel, Alexander Rakhmilevich, Paul M. Sondel
Publikováno v:
Cancer Research. 82:1385-1385
Introduction: Using an in situ vaccine (ISV) regimen consisting of radiation combined with immunocytokine (tumor-targeting mAb linked to IL2), we can cure mice of well established B78 melanoma tumors (B78s). Mice cured of their B78s with ISV demonstr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::16358f8668e02cb699ed998c9e8bc53f
https://doi.org/10.1158/1538-7445.am2022-1385
https://doi.org/10.1158/1538-7445.am2022-1385
Autor:
Jacquelyn A. Hank, Zachary S. Morris, Arika Feils, Luke M. Zangl, Mackenzie Heck, Paul M. Sondel, Anna Hoefges, Peter M. Carlson, Amy K. Erbe, Ravi Patel, Dmitriy Kravtsov, Alexander L. Rakhmilevich
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
Background Mice bearing B78 melanoma tumors can be cured using an in situ vaccine (ISV) regimen that includes radiation (RT) together with immunocytokine (tumor-targeting mAb conjugated to IL-2). B78 melanoma cells, derived from B16 cells, express mi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a0e99ae157ad4d96c41cd15cbe802ab
https://doi.org/10.1136/jitc-2020-sitc2020.0823
https://doi.org/10.1136/jitc-2020-sitc2020.0823
Autor:
Roland Green, Mildred Felder, Mackenzie Heck, Christopher Massey, Todd E. Barnhart, Bryan Glaser, Mark Bercher, Paul M. Sondel, Gerhardt Daniel Justin, Amy K. Erbe, Arika Feils, Sabrina VandenHeuvel, Bonnie Hammer, Jennifer Dennin, Reinier Hernandez, Jacquelyn A. Hank, Jonathan W. Engle
Publikováno v:
Regular and young investigator award abstracts.
Background Disialoganglioside 2 (GD2) is expressed on neuroblastomas as well as melanomas, small cell lung cancers, and sarcomas. Anti-GD2 mAb (Dinutuximab) can be used to treat these cancers and is part of the standard care for neuroblastoma. While
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::39c3da4e53fd2e4003453a9b20ecfd09
https://doi.org/10.1136/jitc-2020-sitc2020.0461
https://doi.org/10.1136/jitc-2020-sitc2020.0461
Autor:
Amy K Erbe, Reinier Hernandez, Daniel Gerhardt, Bonnie Hammer, Mildred Felder, Mark Bercher, Jennifer Dennin, Christopher Massey, Sabrina VandenHeuvel, Arika S Feils, Mackenzie Heck, Jacquelyn A Hank, Bryan Glasser, Roland Green, Paul M Sondel
Publikováno v:
The Journal of Immunology. 204:91.2-91.2
GD2 is expressed on neuroblastomas, as well as melanomas, small cell lung cancers and sarcomas. Anti-GD2 mAb can be used to treat these cancers and is part of the standard care for neuroblastoma. Expressed minimally on normal tissues, GD2 is expresse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::758a4532894b81b378acca5c25b95c62
https://doi.org/10.4049/jimmunol.204.supp.91.2
https://doi.org/10.4049/jimmunol.204.supp.91.2