Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Mackenzie E Malo"'
Publikováno v:
PLoS Genetics, Vol 8, Iss 3, p e1002583 (2012)
Forkhead box O (FOXO) transcription factors have a conserved function in regulating metazoan lifespan. A key function in this process involves the regulation of the cell cycle and stress responses including free radical scavenging. We employed yeast
Externí odkaz:
https://doaj.org/article/6d390d47c6384f8482491f0324c676e0
Autor:
Chandra B. Prabaharan, Sabeena Giri, Kevin J. H. Allen, Katrina E. M. Bato, Therese R. Mercado, Mackenzie E. Malo, Jorge L. C. Carvalho, Ekaterina Dadachova, Maruti Uppalapati
Publikováno v:
Molecules, Vol 28, Iss 15, p 5839 (2023)
Novel therapeutic approaches are much needed for the treatment of osteosarcoma. Targeted radionuclide therapy (TRT) and radioimmunotherapy (RIT) are promising approaches that deliver therapeutic radiation precisely to the tumor site. We have previous
Externí odkaz:
https://doaj.org/article/48fe470b2a6848f39dc41d8d274e15e4
Autor:
Mackenzie E. Malo, Zachary Schultzhaus, Connor Frank, Jillian Romsdahl, Zheng Wang, Ekaterina Dadachova
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 19, Iss , Pp 196-205 (2021)
Melanized fungi have been isolated from some of the harshest radioactive environments, and their ability to thrive in these locations is in part due to the pigment melanin. Melanin imparts a selective advantage to fungi by providing a physical shield
Externí odkaz:
https://doaj.org/article/a96f6150754b4a61b2ec9cf28af41818
Autor:
Yong-guo Zhang, Mackenzie E. Malo, Tanya Tschirhart, Yinglin Xia, Zheng Wang, Ekaterina Dadachova, Jun Sun
Publikováno v:
Toxics, Vol 11, Iss 1, p 13 (2022)
Radiation damage is associated with inflammation and immunity in the intestinal mucosa, including gut microbiota. Melanin has a unique capacity to coordinate a biological reaction in response to environmental stimuli, such as radiation exposure. Thus
Externí odkaz:
https://doaj.org/article/9b7a7a289020432380351a865b373031
Autor:
Wojciech Dawicki, Kevin J.H. Allen, Rubin Jiao, Mackenzie E. Malo, Muath Helal, Mark S. Berger, Dale L. Ludwig, Ekaterina Dadachova
Publikováno v:
OncoImmunology, Vol 8, Iss 8 (2019)
Daratumumab is an anti-CD38 directed monoclonal antibody approved for the treatment of multiple myeloma (MM) and functions primarily via Fc-mediated effector mechanisms such as complement-dependent cytotoxicity (CDC), antibody-dependent cell cytotoxi
Externí odkaz:
https://doaj.org/article/0cb73432045043a4b0fd555fca3b4478
Publikováno v:
International journal of molecular sciences. 23(17)
Nearly 100,000 individuals are expected to be diagnosed with melanoma in the United States in 2022. Treatment options for late-stage metastatic disease up until the 2010s were few and offered only slight improvement to the overall survival. The intro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d825b585eaa82c10eb8f68aeb0faacb1
https://pubmed.ncbi.nlm.nih.gov/36076924
https://pubmed.ncbi.nlm.nih.gov/36076924
Autor:
Kevin J. H. Allen, Rubin Jiao, Mackenzie E. Malo, Connor Frank, Darrell R. Fisher, David Rickles, Ekaterina Dadachova
Publikováno v:
Pharmaceutics, Vol 11, Iss 7, p 348 (2019)
Melanoma is a cancer with increasing incidence and there is a need for alternatives to immunotherapy within effective approaches to treatment of metastatic melanoma. We performed comparative radioimmunotherapy (RIT) of experimental B16-F10 melanoma w
Externí odkaz:
https://doaj.org/article/fac8916038564d71940458814e0fa11a
Autor:
Connor Frank, Zachary Schultzhaus, Mackenzie E. Malo, Jillian Romsdahl, Zheng Wang, Ekaterina Dadachova
Publikováno v:
Computational and Structural Biotechnology Journal
Computational and Structural Biotechnology Journal, Vol 19, Iss, Pp 196-205 (2021)
Computational and Structural Biotechnology Journal, Vol 19, Iss, Pp 196-205 (2021)
Graphical abstract
Highlights • Exophiala dermatitidis is a constitutively melanized yeast that is highly resistant to ionizing radiation. • We analyzed the genome and transcriptomes of E. dermatitidis strains adapted to chronic ionizing rad
Highlights • Exophiala dermatitidis is a constitutively melanized yeast that is highly resistant to ionizing radiation. • We analyzed the genome and transcriptomes of E. dermatitidis strains adapted to chronic ionizing rad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0047c511512dfaad1859989c486b44e1
http://europepmc.org/articles/PMC7772362
http://europepmc.org/articles/PMC7772362
Publikováno v:
Pharmaceutics, Vol 10, Iss 4, p 262 (2018)
(1) Background: Monoclonal antibodies are used in the treatment of multiple conditions including cancer, autoimmune disorders, and infectious diseases. One of the initial steps in the selection of an antibody candidate for further pre-clinical develo
Externí odkaz:
https://doaj.org/article/2517bad1a2be45e1bd3e5fbe52e17b2a
Autor:
Rubin Jiao, Rickles David J, Ekaterina Dadachova, Susan Buhl, Karishma Smart, Zewei Jiang, Mackenzie E. Malo, Ruth A. Bryan, Kevin J. H. Allen, Muath Helal
Publikováno v:
Cancer Medicine, Vol 8, Iss 11, Pp 5289-5300 (2019)
Cancer Medicine
Cancer Medicine
Background Pancreatic ductal adenocarcinoma (PDAC) accounts for >90% of pancreatic malignancies, and has median survival of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74d1ba302654f7359198ab82a487ac19
https://doaj.org/article/9ed1c8cdf1a4417bbfe386cc7289b284
https://doaj.org/article/9ed1c8cdf1a4417bbfe386cc7289b284