Výsledky vyhledávání - "Mackenzie Coden"

Hyperglycemia impairs tolerance and promotes allergic inflammation in mouse models of asthma

Autor: Ashley Queener, Brian M Jeong, Mackenzie Coden, Ton Doan, Matthew Walker, Reina Nagasaka, Sergejs Berdnikovs

Publikováno v: The Journal of Immunology. 204:147.23-147.23

Glucose is a key source of energy in systemic and cellular metabolism and has known pro-inflammatory properties. Metabolic disorders (diabetes, insulin resistance) associate with asthma and other allergic diseases. This study sought to understand the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::171612f74cd3093e19028921999bb20b
https://doi.org/10.4049/jimmunol.204.supp.147.23

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Siglec-F-negative resident eosinophils represent an unexpectedly dominant population in homeostatic murine bone marrow

Autor: Brian M Jeong, Matthew Walker, Mackenzie Coden, Kiwon Nam, Reina Nagasaka, Hiam Abdala-Valencia, Sergejs Berdnikovs

Publikováno v: The Journal of Immunology. 204:63.14-63.14

Bone marrow, while known to be a hematopoietic site for eosinophils, also harbors resident populations of these cells. Identification of such resident eosinophils typically requires flow cytometry-assisted sorting, with Siglec-F as a key marker for i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ee0d033be8b99cb1c5d28d268a6af94b
https://doi.org/10.4049/jimmunol.204.supp.63.14

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Matrix protein Tenascin-C expands and reversibly blocks maturation of eosinophil progenitors

Autor: Ton C. Doan, Brian M. Jeong, Mackenzie Coden, Hiam Abdala-Valencia, Sergejs Berdnikovs

Publikováno v: The Journal of Immunology. 200:103.9-103.9

While eosinophil depletion is a sought after strategy in treating allergic disease, little is known about the local tissue factors regulating eosinophils. In disease, eosinophils encounter provisional extracellular matrix (ECM) glycoproteins such as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7ed69d7050feea0079987411b398758f
https://doi.org/10.4049/jimmunol.200.supp.103.9

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Novel insights into the puberty switch mechanisms of the sex bias in human asthma

Autor: Mackenzie Coden, Brian M. Jeong, Sergio Chiarella, Raul Rodriguez, Sergejs Berdnikovs

Publikováno v: The Journal of Immunology. 200:45.41-45.41

The gender bias in human asthma prevalence changes with puberty, with males having a higher asthma incidence before puberty and females having higher rates after. The mechanisms involved in this switch are unknown. Our previous research showed that m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cf9ddfa5a371b9dfcfc0caf4a1a00c53
https://doi.org/10.4049/jimmunol.200.supp.45.41

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The lung hematopoietic niche supports bone marrow-independent hematopoiesis and contributes to local eosinophil expansion during allergic inflammation

Autor: Brian M. Jeong, Mackenzie Coden, Ton C. Doan, Sergio Chiarella, Raul Rodriguez, Sergejs Berdnikovs

Publikováno v: The Journal of Immunology. 200:44.16-44.16

Bone marrow is classically viewed as the major source of differentiated leukocytes infiltrating tissues from circulation. Recent evidence shows that the lung can potentially function as a hematopoietic organ on its own. This is a novel concept and ti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fbbed82cc278e00bf31288f6342708a9
https://doi.org/10.4049/jimmunol.200.supp.44.16

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