Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Mack Kuo"'
Autor:
Guy A. Schiehser, T. R. Santha Kumar, James C. Sacchettini, John W. Anderson, Sean Ekins, Arba L. Ager, Han Chun Tsai, William R. Jacobs, Mack Kuo, David P. Jacobus, Jacek Terpinski, Joel S. Freundlich, David A. Fidock, Dimitri Sarantakis
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:1022-1025
Exploration of triclosan analogs has led to novel diaryl ureas with significant potency against in vitro cultures of drug-resistant and drug-sensitive strains of the human malaria parasite Plasmodium falciparum. Compound 18 demonstrated EC(50) values
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88b2f88d4f025073854e5f99e80dcc75
https://doi.org/10.1016/j.bmcl.2012.12.022
https://doi.org/10.1016/j.bmcl.2012.12.022
Autor:
Brian B. Gourlie, Remo Perozzo, Mack Kuo, Andrew Janjigian, James C. Sacchettini, Hiroyuki Iwamoto, Jill S. Gregory, Scott F. Sneddon, Christopher Yee, David Alland, Barry N. Kreiswirth, Mark M. Staveski, Marina Leonard, James M. Musser, David A. Fidock, William R. Jacobs, Hector R. Morbidoni
Publikováno v:
Journal of Biological Chemistry. 278:20851-20859
Tuberculosis and malaria together result in an estimated 5 million deaths annually. The spread of multidrug resistance in the most pathogenic causative agents, Mycobacterium tuberculosis and Plasmodium falciparum, underscores the need to identify act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::05c1e437ba7b585d5df0220264c6adaa
https://doi.org/10.1074/jbc.m211968200
https://doi.org/10.1074/jbc.m211968200
Autor:
Geoffrey S. Waldo, Jodie M. Johnston, Edward N. Baker, Radha Chauhan, Min S. Park, Jin KukYang, Bernhard Rupp, David Eisenberg, David Leys, Clare V. Smith, Tom Alber, Kirsty J. McLean, Shekhar C. Mande, Daniel H. Anderson, Marcin I. Apostol, Nandita Bachhawat, Vivek Sharma, William R. Jacobs, Vickery L. Arcus, Thomas C. Terwilliger, Se Won Suh, Andrew W. Munro, Harindarpal S. Gill, Mack Kuo, Avinash Kale, Celia W. Goulding, James C. Sacchettini, J. Shaun Lott, Joel Berendzen
Publikováno v:
Current Drug Target -Infectious Disorders. 2:121-141
Structural genomics, the large-scale determination of protein structures, promises to provide a broad structural foundation for drug discovery. The tuberculosis (TB) Structural Genomics Consortium is devoted to encouraging, coordinating, and facilita
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d91b70308ebf08dc9bb6c94a6f0f2ea
https://doi.org/10.2174/1568005023342551
https://doi.org/10.2174/1568005023342551
Autor:
Amar Bir Singh Sidhu, Robert Bittman, Remo Perozzo, Mack Kuo, Jacob T. Valiyaveettil, David A. Fidock, James C. Sacchettini, William R. Jacobs
Publikováno v:
Journal of Biological Chemistry. 277:13106-13114
The human malaria parasite Plasmodium falciparum synthesizes fatty acids using a type II pathway that is absent in humans. The final step in fatty acid elongation is catalyzed by enoyl acyl carrier protein reductase, a validated antimicrobial drug ta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f62b2e4e970201f911d2da74677f0bb
https://doi.org/10.1074/jbc.m112000200
https://doi.org/10.1074/jbc.m112000200
Autor:
Anthony D. Baughn, Christopher F. Basler, Catherine Vilchèze, David Alland, Joel S. Freundlich, Mack Kuo, William R. Jacobs, Jo Ann A. Tufariello, Lawrence W. Leung, James C. Sacchettini
Publikováno v:
Antimicrobial agents and chemotherapy. 55(8)
Drug resistance in Mycobacterium tuberculosis has become a serious global health threat, which is now complicated by the emergence of extensively drug-resistant strains. New drugs that are active against drug-resistant tuberculosis (TB) are needed. W
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9daaca85bbd5ade75718e3c00db026b1
https://pubmed.ncbi.nlm.nih.gov/21628538
https://pubmed.ncbi.nlm.nih.gov/21628538
Autor:
Helen H. Chen, Laura Chapman, Quoc Hoang, Mack Kuo, Muthian Shanmugasundaram, Anilkumar R. Kore
Publikováno v:
Bioorganicmedicinal chemistry letters. 19(5)
The synthesis and proteolytic inhibitor function of two new tetrapeptides, methoxysuccinyl-Ala-Ala-Pro-Phe-chloromethyl ketone (MeOSuc-AAPF-CH(2)Cl) and methoxysuccinyl-Ala-Pro-Ala-Phe-chloromethyl ketone (MeOSuc-APAF-CH(2)Cl) are described. The effi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3df2e0dc644ba8c88439170cdd466f8
https://pubmed.ncbi.nlm.nih.gov/19211247
https://pubmed.ncbi.nlm.nih.gov/19211247
Autor:
Joel S. Freundlich, Guy A. Schiehser, Hong Ming Shieh, Han Chun Tsai, Juan Carlos Valderramos, Feng Wang, David A. Fidock, T. R. Santha Kumar, Stephanie G. Valderramos, David P. Jacobus, William R. Jacobs, Mack Kuo, Min Yu, John W. Anderson, Louis J. Nkrumah, James C. Sacchettini
Publikováno v:
The Journal of biological chemistry. 282(35)
The x-ray crystal structures of five triclosan analogs, in addition to that of the isoniazid-NAD adduct, are described in relation to their integral role in the design of potent inhibitors of the malarial enzyme Plasmodium falciparum enoyl acyl carri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfbfa4520614a4b739f198ab237d0d30
https://pubmed.ncbi.nlm.nih.gov/17567585
https://pubmed.ncbi.nlm.nih.gov/17567585
Autor:
Min Yu, Juan Carlos Valderramos, Hong Ming Shieh, William R. Jacobs, James C. Sacchettini, Guy A. Schiehser, David P. Jacobus, Dimitri Sarantakis, David A. Fidock, Joel S. Freundlich, John W. Anderson, Edinson Lucumi, Mack Kuo
Publikováno v:
Bioorganicmedicinal chemistry letters. 15(23)
A structure-based approach has been taken to develop 4′-substituted analogs of triclosan that target the key malarial enzyme Plasmodium falciparum enoyl acyl carrier protein reductase (PfENR). Many of these compounds exhibit nanomolar potency again
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a000fecabdad1752ee556235128b8e3e
https://pubmed.ncbi.nlm.nih.gov/16198563
https://pubmed.ncbi.nlm.nih.gov/16198563
Autor:
William R. Jacobs, Catherine Vilchèze, Torin R. Weisbrod, Mack Kuo, James C. Sacchettini, Hector R. Morbidoni, Hiroyuki Iwamoto
Publikováno v:
Journal of bacteriology. 182(14)
The mechanism of action of isoniazid (INH), a first-line antituberculosis drug, is complex, as mutations in at least five different genes ( katG , inhA , ahpC , kasA , and ndh ) have been found to correlate with isoniazid resistance. Despite this com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d01b2a3796c61cdf3e5ac6cb09148038
https://pubmed.ncbi.nlm.nih.gov/10869086
https://pubmed.ncbi.nlm.nih.gov/10869086
Autor:
David P. Jacobus, Guy A. Schiehser, Min Yu, William R. Jacobs, John W. Anderson, Edinson Lucumi, Mack Kuo, Dimitri Sarantakis, Hong Ming Shieh, David A. Fidock, James C. Sacchettini, Joel S. Freundlich, Juan Carlos Valderramos
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:3618-3619
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cf00d820f39b5360d91348bb62b64e71
https://doi.org/10.1016/j.bmcl.2005.12.054
https://doi.org/10.1016/j.bmcl.2005.12.054