Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Mack Flinspach"'
Autor:
Jie Yin, Yanyong Kang, Aaron P. McGrath, Karen Chapman, Megan Sjodt, Eiji Kimura, Atsutoshi Okabe, Tatsuki Koike, Yuhei Miyanohana, Yuji Shimizu, Rameshu Rallabandi, Peng Lian, Xiaochen Bai, Mack Flinspach, Jef K. De Brabander, Daniel M. Rosenbaum
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Abstract The OX2 orexin receptor (OX2R) is a highly expressed G protein-coupled receptor (GPCR) in the brain that regulates wakefulness and circadian rhythms in humans. Antagonism of OX2R is a proven therapeutic strategy for insomnia drugs, and agoni
Externí odkaz:
https://doaj.org/article/9405c8a136a547eebb4d8f70de895b56
Autor:
Jie Yin, Yanyong Kang, Aaron P. McGrath, Karen Chapman, Megan Sjodt, Eiji Kimura, Atsutoshi Okabe, Tatsuki Koike, Yuhei Miyanohana, Yuji Shimizu, Rameshu Rallabandi, Peng Lian, Xiaochen Bai, Mack Flinspach, Jef K. De Brabander, Daniel M. Rosenbaum
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-2 (2023)
Externí odkaz:
https://doaj.org/article/9a0f713de8cb43e89a329843e0e714da
Autor:
Robert A. Neff, Mack Flinspach, Alan Gibbs, Amy Y. Shih, Natali A. Minassian, Yi Liu, Ross Fellows, Ondrej Libiger, Stephanie Young, Michael W. Pennington, Michael J. Hunter, Alan D. Wickenden
Publikováno v:
Journal of Biological Chemistry. 295:1315-1327
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c42a1ce24d936c9dc2af72dbb0b9d557
https://doi.org/10.1016/s0021-9258(17)49888-7
https://doi.org/10.1016/s0021-9258(17)49888-7
Autor:
Amy Y. Shih, Ondrej Libiger, Stephanie Young, Alan Gibbs, Alan D. Wickenden, Michael J. Hunter, Ross Fellows, Yi Liu, Robert A. Neff, Michael W. Pennington, Natali A. Minassian, Mack Flinspach
Publikováno v:
Journal of Biological Chemistry. 295:1315-1327
Pain is a significant public health burden in the United States, and current treatment approaches rely heavily on opioids, which often have limited efficacy and can lead to addiction. In humans, functional loss of the voltage-gated sodium channel Nav
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8b3333971182bd93835c976bcc0d6718
https://doi.org/10.1074/jbc.ra119.011318
https://doi.org/10.1074/jbc.ra119.011318
Autor:
Robert A, Neff, Mack, Flinspach, Alan, Gibbs, Amy Y, Shih, Natali A, Minassian, Yi, Liu, Ross, Fellows, Ondrej, Libiger, Stephanie, Young, Michael W, Pennington, Michael J, Hunter, Alan D, Wickenden
Publikováno v:
J Biol Chem
Pain is a significant public health burden in the United States, and current treatment approaches rely heavily on opioids, which often have limited efficacy and can lead to addiction. In humans, functional loss of the voltage-gated sodium channel Na(
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1a7d71b7a0b75aaac86abe5aa31806d9
https://pubmed.ncbi.nlm.nih.gov/31871053
https://pubmed.ncbi.nlm.nih.gov/31871053
Autor:
Q. Xu, Tony L. Yaksh, William A. Eckert, Michael J. Hunter, Rebecca Hagan, J. Freedman, M. Zhou, A. D. Piekarz, Ross Fellows, Rachelle Bonesteel, Kelly A. Eddinger, Michael W. Pennington, Alan Gibbs, Yanfang Liu, Alan D. Wickenden, Ronald V. Swanson, Robert A. Neff, Mack Flinspach
Publikováno v:
Scientific Reports
Scientific reports, vol 7, iss 1
Scientific reports, vol 7, iss 1
Pain places a devastating burden on patients and society and current pain therapeutics exhibit limitations in efficacy, unwanted side effects and the potential for drug abuse and diversion. Although genetic evidence has clearly demonstrated that the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d007efa4fb9267ccd4fec38368d0f7cc
https://doi.org/10.1038/srep39662
https://doi.org/10.1038/srep39662
Autor:
Grzegorz Bulaj, Pradip K. Bandyopadhyay, Yi Liu, Shrinivasan Raghuraman, Baldomero M. Olivera, Layla Azam, Natali A. Minassian, Marshall Bern, Beatrix Ueberheide, Rebecca Hagan, H. Mimi Zhou, Brad R. Green, Julita S. Imperial, Doju Yoshikami, Alan D. Wickenden, Aleksandra Walewska, Joanna Gajewiak, Min Min Zhang, Mack Flinspach
Publikováno v:
Proceedings of the National Academy of Sciences. 111:2758-2763
A cone snail venom peptide, μO§-conotoxin GVIIJ from Conus geographus, has a unique posttranslational modification, S-cysteinylated cysteine, which makes possible formation of a covalent tether of peptide to its target Na channels at a distinct lig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e16aa93a382b2f4eabc990179cc3ecc5
https://doi.org/10.1073/pnas.1324189111
https://doi.org/10.1073/pnas.1324189111
Autor:
Ross Fellows, Amy Y. Shih, Michael J. Hunter, Alan Gibbs, Judith Ann Connor, Natali A. Minassian, Yi Liu, Steven W. Sutton, Matthew Husovsky, Tara Mirzadegan, Robert A. Neff, Alan D. Wickenden, Mack Flinspach, Serena M. Nelson
Publikováno v:
Journal of Biological Chemistry. 288:22707-22720
Voltage-gated sodium channels (VGSCs) are essential to the normal function of the vertebrate nervous system. Aberrant function of VGSCs underlies a variety of disorders, including epilepsy, arrhythmia, and pain. A large number of animal toxins target
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ba133dfd50309ab97efc52c22489636
https://doi.org/10.1074/jbc.m113.461392
https://doi.org/10.1074/jbc.m113.461392
Autor:
Mack Flinspach, Hui Huang, Huiying Li, Joumana Jamal, Richard B. Silverman, Thomas L. Poulos, Weiping Yang
Publikováno v:
Biochemistry. 43:5181-5187
In a continuing effort to unravel the structural basis for isoform-selective inhibition of nitric oxide synthase (NOS) by various inhibitors, we have determined the crystal structures of the nNOS and eNOS heme domain bound with two D-nitroarginine-co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9f8a250a80801c4f9f4e6b136bbe55b
https://doi.org/10.1021/bi0361867
https://doi.org/10.1021/bi0361867
Autor:
Richard B. Silverman, Thomas L. Poulos, Weiping Yang, Elizabeth A. Litzinger, Hui Huang, José Antonio Gómez-Vidal, Huiying Li, Mack Flinspach, Jung-Mi Hah, Joumana Jamal
Publikováno v:
Nature Structural & Molecular Biology. 11:54-59
Three nitric oxide synthase (NOS) isoforms, eNOS, nNOS and iNOS, generate nitric oxide (NO) crucial to the cardiovascular, nervous and host defense systems, respectively. Development of isoform-selective NOS inhibitors is of considerable therapeutic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d99b7ccd886268f156107ccab77bdfd
https://doi.org/10.1038/nsmb704
https://doi.org/10.1038/nsmb704