Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Maciej T, Nogalski"'
Autor:
Maciej T. Nogalski, Alexander Solovyov, Anupriya S. Kulkarni, Niyati Desai, Adam Oberstein, Arnold J. Levine, David T. Ting, Thomas Shenk, Benjamin D. Greenbaum
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
The human genome includes a large amount of repetitive sequence, such as human satellite II (HSATII), but their function remains largely unknown. Here, Nogalski et al. show that herpesvirus infection induces HSATII RNA expression, which in turn affec
Externí odkaz:
https://doaj.org/article/0c0a14c407d84879b5ec6d1592ca8488
Autor:
Niyati Desai, Maciej T. Nogalski, Alexander Solovyov, David T. Ting, Arnold J. Levine, Benjamin Greenbaum, Adam Oberstein, Anupriya S. Kulkarni, Thomas Shenk
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Nature Communications
Nature Communications
Tandem satellite repeats account for 3% of the human genome. One of them, Human Satellite II (HSATII), is highly expressed in several epithelial cancers and cancer cell lines. Here we report an acute induction of HSATII RNA in human cells infected wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::706c4dc56cec6fef3d12c50c2d2b1afe
https://doaj.org/article/0c0a14c407d84879b5ec6d1592ca8488
https://doaj.org/article/0c0a14c407d84879b5ec6d1592ca8488
Publikováno v:
Proc Natl Acad Sci U S A
The tryptophan metabolite, kynurenine, is known to be produced at elevated levels within human cytomegalovirus (HCMV)-infected fibroblasts. Kynurenine is an endogenous aryl hydrocarbon receptor (AhR) ligand. Here we show that the AhR is activated fol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b6b14bc8772ad5433c11339f96dc587
https://doi.org/10.1073/pnas.2026336118
https://doi.org/10.1073/pnas.2026336118
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2244
Human cytomegalovirus (HCMV) is a betaherpesvirus with a global seroprevalence of 60-90%. HCMV is the leading cause of congenital infections and poses a great health risk to immunocompromised individuals. Although HCMV infection is typically asymptom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::13e4ba6221861749f21e5c51ca38bc71
https://pubmed.ncbi.nlm.nih.gov/33555579
https://pubmed.ncbi.nlm.nih.gov/33555579
Publikováno v:
Methods in Molecular Biology ISBN: 9781071611104
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::18b4fd01fc2591b7799169847ee67486
https://doi.org/10.1007/978-1-0716-1111-1_1
https://doi.org/10.1007/978-1-0716-1111-1_1
Autor:
Maciej T. Nogalski, Thomas Shenk
Publikováno v:
Proc Natl Acad Sci U S A
Pericentromeric human satellite II (HSATII) repeats are normally silent but can be actively transcribed in tumor cells, where increased HSATII copy number is associated with a poor prognosis in colon cancer, and in human cytomegalovirus (HCMV)-infect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35baf48d81c20669c74d8a2f3498d7c9
https://pubmed.ncbi.nlm.nih.gov/33257565
https://pubmed.ncbi.nlm.nih.gov/33257565
Autor:
Maciej T Nogalski, Gary C T Chan, Emily V Stevenson, Donna K Collins-McMillen, Andrew D Yurochko
Publikováno v:
PLoS Pathogens, Vol 9, Iss 7, p e1003463 (2013)
We have established that HCMV acts as a specific ligand engaging and activating cellular integrins on monocytes. As a result, integrin signaling via Src activation leads to the functional activation of paxillin required for efficient viral entry and
Externí odkaz:
https://doaj.org/article/e08ee6e133b24746a9af40f6a861e6db
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 116(38)
Human cytomegalovirus (HCMV) manipulates many aspects of host cell biology to create an intracellular milieu optimally supportive of its replication and spread. Our study reveals that levels of several components of the purinergic signaling system, i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b52cf90cf26d26a4202e3c701fdaa8c1
https://pubmed.ncbi.nlm.nih.gov/31481624
https://pubmed.ncbi.nlm.nih.gov/31481624
Autor:
Stephen J. Cieply, Emily V. Stevenson, Andrew D. Yurochko, Maciej T. Nogalski, Gary C. Chan, Jung Heon Kim, John R. Caskey, Donna Collins-McMillen
Publikováno v:
Journal of Virology. 90:2356-2371
Monocytes play a key role in the hematogenous dissemination of human cytomegalovirus (HCMV) to target organ systems. To infect monocytes and reprogram them to deliver infectious virus, HCMV must overcome biological obstacles, including the short life
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::396b3a61db46673f5e3d60ca9129abcb
https://doi.org/10.1128/jvi.01994-15
https://doi.org/10.1128/jvi.01994-15
Autor:
Stephen J. Cieply, Caroline R. Spohn, Andrew D. Yurochko, Gary C. Chan, Emily V. Stevenson, Donna Collins-McMillen, Maciej T. Nogalski, Byeong Jae Lee, Jung Heon Kim, Robert W. Frost
Publikováno v:
Journal of Virology. 91
Human cytomegalovirus (HCMV) infects peripheral blood monocytes and triggers biological changes that promote viral dissemination and persistence. We have shown that HCMV induces a proinflammatory state in infected monocytes, resulting in enhanced mon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de6512f03d5e410c1930e255b04c7bb9
https://doi.org/10.1128/jvi.00622-17
https://doi.org/10.1128/jvi.00622-17