Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Maciej Swat"'
Publikováno v:
Pharmaceuticals, Vol 13, Iss 10, p 265 (2020)
The kinetic model of Prostaglandin H Synthase-1 (PGHS-1) was developed to investigate its complex network kinetics and non-steroidal anti-inflammatory drugs (NSAIDs) efficacy in different in vitro and in vivo conditions. To correctly describe the com
Externí odkaz:
https://doaj.org/article/33718472102a40cbab3dfeb0e2f1eaa5
Autor:
James P Sluka, Xiao Fu, Maciej Swat, Julio M Belmonte, Alin Cosmanescu, Sherry G Clendenon, John F Wambaugh, James A Glazier
Publikováno v:
PLoS ONE, Vol 11, Iss 9, p e0162428 (2016)
We describe a multi-scale, liver-centric in silico modeling framework for acetaminophen pharmacology and metabolism. We focus on a computational model to characterize whole body uptake and clearance, liver transport and phase I and phase II metabolis
Externí odkaz:
https://doaj.org/article/16b20de816ff4c75b82958dcd34c4023
Autor:
Abbas Shirinifard, James Alexander Glazier, Maciej Swat, J Scott Gens, Fereydoon Family, Yi Jiang, Hans E Grossniklaus
Publikováno v:
PLoS Computational Biology, Vol 8, Iss 5, p e1002440 (2012)
Choroidal neovascularization (CNV) of the macular area of the retina is the major cause of severe vision loss in adults. In CNV, after choriocapillaries initially penetrate Bruch's membrane (BrM), invading vessels may regress or expand (CNV initiatio
Externí odkaz:
https://doaj.org/article/7aec8a87954f41b3b0c14dd03743282c
Publikováno v:
PLoS ONE, Vol 6, Iss 10, p e24999 (2011)
The actions of cell adhesion molecules, in particular, cadherins during embryonic development and morphogenesis more generally, regulate many aspects of cellular interactions, regulation and signaling. Often, a gradient of cadherin expression levels
Externí odkaz:
https://doaj.org/article/b8772b2988374f9a92d548ec06d16749
Publikováno v:
PLoS Computational Biology, Vol 6, p e1000841 (2010)
We present a computer simulation and associated experimental validation of assembly of glial-like support cells into the interweaving hexagonal lattice that spans the Drosophila pupal eye. This process of cell movements organizes the ommatidial array
Externí odkaz:
https://doaj.org/article/7513861bc38845cda7f26d01cc3b3ed0
Autor:
Nikodem J Poplawski, Abbas Shirinifard, Ubirajara Agero, J Scott Gens, Maciej Swat, James A Glazier
Publikováno v:
PLoS ONE, Vol 5, Iss 5, p e10641 (2010)
We use the Glazier-Graner-Hogeweg model to simulate three-dimensional (3D), single-phenotype, avascular tumors growing in an homogeneous tissue matrix (TM) supplying a single limiting nutrient. We study the effects of two parameters on tumor morpholo
Externí odkaz:
https://doaj.org/article/3bb657c5e84b4a49bd1247d8db9f10c5
Autor:
Abbas Shirinifard, J Scott Gens, Benjamin L Zaitlen, Nikodem J Popławski, Maciej Swat, James A Glazier
Publikováno v:
PLoS ONE, Vol 4, Iss 10, p e7190 (2009)
We present a 3D multi-cell simulation of a generic simplification of vascular tumor growth which can be easily extended and adapted to describe more specific vascular tumor types and host tissues. Initially, tumor cells proliferate as they take up th
Externí odkaz:
https://doaj.org/article/8a0b88616fc840fea6ac27cfdf8f80ae
Autor:
Bridget S. Wilson, Yi Jiang, Melanie E. Moses, Carolyn Y. Muller, Maciej Swat, Rebecca J. Lee, Mara P. Steinkamp, Kimberly R. Kanigel Winner
In ovarian cancer, metastasis is typically confined to the peritoneum. Surgical removal of the primary tumor and macroscopic secondary tumors is a common practice, but more effective strategies are needed to target microscopic spheroids persisting in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83f8b40de10b5377c823e165948c8bf0
https://doi.org/10.1158/0008-5472.c.6508148.v1
https://doi.org/10.1158/0008-5472.c.6508148.v1
Autor:
Bridget S. Wilson, Yi Jiang, Melanie E. Moses, Carolyn Y. Muller, Maciej Swat, Rebecca J. Lee, Mara P. Steinkamp, Kimberly R. Kanigel Winner
Further details on model assumptions, statistical analysis, and model parameters. Supplementary Figure 1: Vascular Densities in Bowel and Omentum Metastatic Sites for Individual Patients Do Not Correlate. Supplementary Figure 2: Box Plots of Vascular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30b54255420211ea22ac3655222cf58f
https://doi.org/10.1158/0008-5472.22411082
https://doi.org/10.1158/0008-5472.22411082
Autor:
Tyson R. Shepherd, Clint Davis, Charles D. Johnson, Stephen Tanner, Jocelyne Bruand, Thomas Hraha, Tian Tian, Steven Alvarez, Eric Abbate, Shea Lambert, Timothy M. Shaver, Bryan A Leland, Paul Hardenbol, Michael Graige, Stephen Federowicz, Mathew Barber, Scott Bolte, Christopher G. Abraham, Miles Gander, Simon Cawley, Gozde Gencer, J. Christian J. Ray, Andrew D. Garst, Richard Fox, Maciej Swat, Surbhi Jain, Matthew Estes, Kara Juneau, Craig A. Struble, Ken Wishart, Andrea L. Halweg-Edwards, Deanna M. Church, Francesca Pearson, Eileen Colie Spindler, Nandini Krishnamurthy, Chad Sanada, Joshua Shorenstein
Genome engineering methodologies are transforming biological research and discovery. Approaches based on CRISPR technology have been broadly adopted and there is growing interest in the generation of massively parallel edited cell libraries. Comparin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3fe0e8bc1ff7b70e400f9a7f173cf58a
https://doi.org/10.1101/2021.09.23.458228
https://doi.org/10.1101/2021.09.23.458228