Zobrazeno 1 - 10
of 75
pro vyhledávání: '"Maciej Paszkowski"'
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Design of recombinases with new target sites is usually achieved through cycles of directed molecular evolution. Here the authors report Recombinase Generator, RecGen, an algorithm for generation of designer-recombinases; they perform experimental va
Externí odkaz:
https://doaj.org/article/98c42521ad4941e8b782b57f29143de6
Publikováno v:
Lubricants, Vol 11, Iss 10, p 425 (2023)
This study examines the effect of mining pollutants and wear products on the rheological and tribological properties of a lubricating grease working in the microclimate of the Polkowice-Sieroszowice mine belonging to the KGHM Polska Miedź Group (Pol
Externí odkaz:
https://doaj.org/article/c1a6b20d82614a209d88704123bf1e71
Autor:
Felix Lansing, Liliya Mukhametzyanova, Teresa Rojo-Romanos, Kentaro Iwasawa, Masaki Kimura, Maciej Paszkowski-Rogacz, Janet Karpinski, Tobias Grass, Jan Sonntag, Paul Martin Schneider, Ceren Günes, Jenna Hoersten, Lukas Theo Schmitt, Natalia Rodriguez-Muela, Ralf Knöfler, Takanori Takebe, Frank Buchholz
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Correction of disease-causing large genomic inversions remains challenging. Here, the authors developed a dual designer-recombinase system (RecF8) that efficiently corrects a 140 kb inversion frequently found in patients with severe Hemophilia A.
Externí odkaz:
https://doaj.org/article/8d46d2035aed42e78c73c8d76348317f
Autor:
Ceren Güneş, Maciej Paszkowski-Rogacz, Susann Rahmig, Shahryar Khattak, Aylin Camgöz, Martin Wermke, Andreas Dahl, Martin Bornhäuser, Claudia Waskow, Frank Buchholz
Publikováno v:
Stem Cell Reports, Vol 12, Iss 5, Pp 1084-1098 (2019)
Summary: Large-scale RNAi screens are a powerful approach to identify functions of genes in a cell-type-specific manner. For model organisms, genetically identical (isogenic) cells from different cell types are readily available, making comparative s
Externí odkaz:
https://doaj.org/article/c7e4e0564b58471387e6cfe367555d57
Autor:
Olga Alexandra Sidorova, Shady Sayed, Maciej Paszkowski-Rogacz, Michael Seifert, Aylin Camgöz, Ingo Roeder, Martin Bornhäuser, Christian Thiede, Frank Buchholz
Publikováno v:
Cells, Vol 11, Iss 5, p 854 (2022)
DNA-methyltransferase 3A (DNMT3A) mutations belong to the most frequent genetic aberrations found in adult acute myeloid leukemia (AML). Recent evidence suggests that these mutations arise early in leukemogenesis, marking leukemic progenitors and ste
Externí odkaz:
https://doaj.org/article/95b7956488124b99b7253265acaa0fda
Autor:
Debojyoti Chakraborty, Maciej Paszkowski-Rogacz, Nicolas Berger, Li Ding, Jovan Mircetic, Jun Fu, Vytautas Iesmantavicius, Chunaram Choudhary, Konstantinos Anastassiadis, A. Francis Stewart, Frank Buchholz
Publikováno v:
Cell Reports, Vol 21, Iss 11, Pp 3012-3021 (2017)
Long noncoding RNAs (lncRNAs) have been implicated in diverse biological processes, including embryonic stem cell (ESC) maintenance. However, their functional mechanisms remain largely undefined. Here, we show that the lncRNA Panct1 regulates the tra
Externí odkaz:
https://doaj.org/article/26d7fd4feca44e1e81e064abd4826fe8
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
TP53 is mutated in many cancers, a system to detect and selectively eliminate p53 mutant cells is an attractive therapeutic strategy. Here, the authors present a genetic sensor that can detect p53 activity and is coupled to the thymidine kinase gene,
Externí odkaz:
https://doaj.org/article/a523286eef224f22b2c54b9effda2530
Autor:
Dennis Kappei, Marion Scheibe, Maciej Paszkowski-Rogacz, Alina Bluhm, Toni Ingolf Gossmann, Sabrina Dietz, Mario Dejung, Holger Herlyn, Frank Buchholz, Matthias Mann, Falk Butter
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
Since protein interactions can be sensitive to small sequence changes, phylogenomics alone gives limited insight into protein functional evolution. Here, the authors illustrate how the combination of phylogenomics and interaction proteomics helps elu
Externí odkaz:
https://doaj.org/article/8d2c6013e78f4544b5d7c1228b6c7357
Autor:
Bauyrzhan Rakhadilov, Nurgamit Kantay, Zhuldyz Sagdoldina, Dosym Erbolatuly, Gulsym Bektasova, Maciej Paszkowski
Publikováno v:
Materials Research Express, Vol 8, Iss 5, p 056402 (2021)
This paper presents the results of experimental investigations of the physical and mechanical properties, structure and surface morphology of Al _2 O _3 - and ZrO _2 -based coatings deposited by detonation spraying. The coatings were sprayed onto tit
Externí odkaz:
https://doaj.org/article/da8d9feb23d542618f81b7ac9458bb96
Autor:
Maciej Paszkowski, Piotr Czuczwar, Sławomir Woźniak, Monika Paszkowska, Piotr Szkodziak, Krzysztof Patyra, Tomasz Paszkowski
Publikováno v:
Annals of Agricultural and Environmental Medicine, Vol 23, Iss 1, Pp 153-156 (2015)
Introduction and objective Spontaneous abortion constitutes one of the most frequent complication of human pregnancy. Despite intensive research efforts undertaken to date, the etiopathogenesis of early pregnancy loss has not been fully elucidated. T
Externí odkaz:
https://doaj.org/article/281c7022ca404ecdbdbe878147db7114