Zobrazeno 1 - 10
of 76
pro vyhledávání: '"Maciej M. Markiewski"'
Autor:
Aristotelis Astrinidis, Chenggang Li, Erik Y. Zhang, Xueheng Zhao, Shuyang Zhao, Minzhe Guo, Tasnim Olatoke, Ushodaya Mattam, Rong Huang, Alan G. Zhang, Lori Pitstick, Elizabeth J. Kopras, Nishant Gupta, Roman Jandarov, Eric P. Smith, Elizabeth Fugate, Diana Lindquist, Maciej M. Markiewski, Magdalena Karbowniczek, Kathryn A. Wikenheiser-Brokamp, Kenneth D. R. Setchell, Francis X. McCormack, Yan Xu, Jane J. Yu
Publikováno v:
JCI Insight, Vol 8, Iss 9 (2023)
Tuberous sclerosis complex (TSC) is characterized by multisystem, low-grade neoplasia involving the lung, kidneys, brain, and heart. Lymphangioleiomyomatosis (LAM) is a progressive pulmonary disease affecting almost exclusively women. TSC and LAM are
Externí odkaz:
https://doaj.org/article/ad95cbd9b11f46108c30b103c315f140
Autor:
Mariam Oladejo, Hong-My Nguyen, Ashok Silwal, Britney Reese, Wyatt Paulishak, Maciej M. Markiewski, Laurence M. Wood
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Targeting tumor-associated angiogenesis is currently at the forefront of renal cell carcinoma (RCC) therapy, with sunitinib and bevacizumab leading to increased survival in patients with metastatic RCC (mRCC). However, resistance often occurs shortly
Externí odkaz:
https://doaj.org/article/8d8d0892bcd349818ff349fad6d22f6e
Autor:
Martin Kolev, Madhumita Das, Monica Gerber, Scott Baver, Pascal Deschatelets, Maciej M. Markiewski
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
The role of complement in cancer has received increasing attention over the last decade. Recent studies provide compelling evidence that complement accelerates cancer progression. Despite the pivotal role of complement in fighting microbes, complemen
Externí odkaz:
https://doaj.org/article/1d9f607e85c3424b9f5a277c18a5dae6
Publikováno v:
Frontiers in Immunology, Vol 11 (2021)
Nanoparticle-based anticancer medications were first approved for cancer treatment almost 2 decades ago. Patients benefit from these approaches because of the targeted-drug delivery and reduced toxicity, however, like other therapies, adverse reactio
Externí odkaz:
https://doaj.org/article/706b3d6d470940c0a59a1a8f2f91abbf
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Externí odkaz:
https://doaj.org/article/05cd822fd1f144c194d75078232dc4ee
Autor:
Jun-Hung Cho, Bhaumik Patel, Santosh Bonala, Sasikanth Manne, Yan Zhou, Surya K. Vadrevu, Jalpa Patel, Marco Peronaci, Shanawaz Ghouse, Elizabeth P. Henske, Fabrice Roegiers, Krinio Giannikou, David J. Kwiatkowski, Hossein Mansouri, Maciej M. Markiewski, Brandon White, Magdalena Karbowniczek
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
Tuberous sclerosis complex (TSC) is a rare genetic condition causing tumours with differentiation abnormalities; however the molecular mechanisms causing these defects are unclear. Here the authors show that Notch cooperates with Rheb to block cell d
Externí odkaz:
https://doaj.org/article/c032945d8d7b42608e09e9eacf6389a4
Autor:
Nehal Gupta, Shreyas Gaikwad, Itishree Kaushik, Stephen E. Wright, Maciej M. Markiewski, Sanjay K. Srivastava
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 10, p 5150 (2021)
A major contributing factor in triple-negative breast cancer progression is its ability to evade immune surveillance. One mechanism for this immunosuppression is through ribosomal protein S19 (RPS19), which facilitates myeloid-derived suppressor cell
Externí odkaz:
https://doaj.org/article/3ba2af4e1d5a4b52abb099f52a925b51
Publikováno v:
Antibodies, Vol 9, Iss 4, p 67 (2020)
The link of the complement system to angiogenesis has remained circumstantial and speculative for several years. Perhaps the most clinically relevant example of possible involvement of complement in pathological neovascularization is age-related macu
Externí odkaz:
https://doaj.org/article/27b12425a83149c28a3b8443c5b99456
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Complement is an effector of innate immunity and a bridge connecting innate immunity and subsequent adaptive immune responses. It is essential for protection against infections and for orchestrating inflammatory responses. Recent studies have also de
Externí odkaz:
https://doaj.org/article/3c3ed83df0f84ab6af2d624ca5a137c0
Autor:
Tasnim Olatoke, Andrew Wagner, Aristotelis Astrinidis, Erik Y. Zhang, Minzhe Guo, Alan G. Zhang, Ushodaya Mattam, Elizabeth J. Kopras, Nishant Gupta, Eric P. Smith, Magdalena Karbowniczek, Maciej M. Markiewski, Kathryn A. Wikenheiser-Brokamp, Jeffrey A. Whitsett, Francis X. McCormack, Yan Xu, Jane J. Yu
Publikováno v:
Science Advances. 9
Lymphangioleiomyomatosis (LAM) is a rare, progressive lung disease that predominantly affects women. LAM cells carry TSC1/TSC2 mutations, causing mTORC1 hyperactivation and uncontrolled cell growth. mTORC1 inhibitors stabilize lung function; however,