The multikinase inhibitor RXDX-105 is effective against neuroblastoma in vitro and in vivo

Autor: Flynn, Sean M, Lesperance, Jacqueline, Macias, Andrew, Phanhthilath, Nikki, Paul, Megan Rose, Kim, Jong Wook, Tamayo, Pablo, Zage, Peter E

Publikováno v: Oncotarget, vol 10, iss 59

Neuroblastoma is the most common extracranial solid tumor of childhood and accounts for 15% of all pediatric cancer-related deaths. New therapies are needed to improve outcomes for children with high-risk and relapsed tumors. Inhibitors of the RET ki

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https://escholarship.org/uc/item/3b1491sn

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The multikinase inhibitor RXDX-105 is effective against neuroblastoma in vitro and in vivo .

Autor: Flynn SM; Department of Surgery, University of California San Diego, La Jolla, CA, USA., Lesperance J; Department of Pediatrics, Division of Hematology-Oncology, University of California San Diego, La Jolla, CA, USA., Macias A; Department of Pediatrics, Division of Hematology-Oncology, University of California San Diego, La Jolla, CA, USA., Phanhthilath N; Department of Pediatrics, Division of Hematology-Oncology, University of California San Diego, La Jolla, CA, USA., Paul MR; Department of Pediatrics, Division of Hematology-Oncology, University of California San Diego, La Jolla, CA, USA.; Peckham Center for Cancer and Blood Disorders, Rady Children's Hospital, San Diego, CA, USA., Kim JW; Department of Medicine, Moores Cancer Center, University of California San Diego, La Jolla, CA, USA., Tamayo P; Department of Medicine, Moores Cancer Center, University of California San Diego, La Jolla, CA, USA., Zage PE; Department of Pediatrics, Division of Hematology-Oncology, University of California San Diego, La Jolla, CA, USA.; Peckham Center for Cancer and Blood Disorders, Rady Children's Hospital, San Diego, CA, USA.; Department of Medicine, Moores Cancer Center, University of California San Diego, La Jolla, CA, USA.

Publikováno v: Oncotarget [Oncotarget] 2019 Oct 29; Vol. 10 (59), pp. 6323-6333. Date of Electronic Publication: 2019 Oct 29 (Print Publication: 2019).