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Autor:
Belov AM, Kozole J, Bean MF, Machutta CA, Zhang G, Gao EN, Ghislain L; Beckman Coulter Life Sciences, 170 Rose Orchard Way, San Jose, California 95134, United States., Datwani SS; Beckman Coulter Life Sciences, 170 Rose Orchard Way, San Jose, California 95134, United States., Leveridge M, Annan RS
Publikováno v:
Analytical chemistry [Anal Chem] 2020 Oct 20; Vol. 92 (20), pp. 13847-13854. Date of Electronic Publication: 2020 Oct 05.
Autor:
Machutta CA, Kollmann CS, Lind KE, Bai X, Chan PF, Huang J, Ballell L, Belyanskaya S, Besra GS, Barros-Aguirre D, Bates RH, Centrella PA, Chang SS, Chai J, Choudhry AE, Coffin A, Davie CP, Deng H, Deng J, Ding Y, Dodson JW, Fosbenner DT, Gao EN, Graham TL, Graybill TL, Ingraham K, Johnson WP, King BW, Kwiatkowski CR, Lelièvre J, Li Y, Liu X, Lu Q, Lehr R, Mendoza-Losana A, Martin J, McCloskey L, McCormick P, O'Keefe HP, O'Keeffe T, Pao C, Phelps CB, Qi H, Rafferty K, Scavello GS, Steiginga MS, Sundersingh FS, Sweitzer SM, Szewczuk LM, Taylor A, Fern Toh M, Wang J, Wang M, Wilkins DJ, Xia B, Yao G, Zhang J, Zhou J, Donahue CP, Messer JA, Holmes D, Arico-Muendel CC, Pope AJ, Gross JW, Evindar G
Publikováno v:
Nature communications [Nat Commun] 2018 Jul 13; Vol. 9, pp. 16227. Date of Electronic Publication: 2018 Jul 13.
Prioritizing multiple therapeutic targets in parallel using automated DNA-encoded library screening.
Autor:
Machutta CA; GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, USA., Kollmann CS; GlaxoSmithKline, 830 Winter Street, Waltham, Massachusetts 02451, USA., Lind KE; GlaxoSmithKline, 830 Winter Street, Waltham, Massachusetts 02451, USA., Bai X; GlaxoSmithKline, 830 Winter Street, Waltham, Massachusetts 02451, USA., Chan PF; GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, USA., Huang J; GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, USA., Ballell L; GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, Madrid 28760, Spain., Belyanskaya S; GlaxoSmithKline, 830 Winter Street, Waltham, Massachusetts 02451, USA., Besra GS; University of Birmingham, School of Biosciences, Edgbaston, Birmingham B15 2TT, UK., Barros-Aguirre D; GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, Madrid 28760, Spain., Bates RH; GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, Madrid 28760, Spain., Centrella PA; GlaxoSmithKline, 830 Winter Street, Waltham, Massachusetts 02451, USA., Chang SS; GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, USA., Chai J; GlaxoSmithKline, 830 Winter Street, Waltham, Massachusetts 02451, USA., Choudhry AE; GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, USA., Coffin A; GlaxoSmithKline, 830 Winter Street, Waltham, Massachusetts 02451, USA., Davie CP; GlaxoSmithKline, 830 Winter Street, Waltham, Massachusetts 02451, USA., Deng H; GlaxoSmithKline, 830 Winter Street, Waltham, Massachusetts 02451, USA., Deng J; GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, USA., Ding Y; GlaxoSmithKline, 830 Winter Street, Waltham, Massachusetts 02451, USA., Dodson JW; GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, USA., Fosbenner DT; GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, USA., Gao EN; GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, USA., Graham TL; GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, USA., Graybill TL; GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, USA., Ingraham K; GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, USA., Johnson WP; GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, USA., King BW; GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, USA., Kwiatkowski CR; GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, USA., Lelièvre J; GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, Madrid 28760, Spain., Li Y; GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, USA., Liu X; GlaxoSmithKline, 830 Winter Street, Waltham, Massachusetts 02451, USA., Lu Q; GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, USA., Lehr R; GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, USA., Mendoza-Losana A; GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, Madrid 28760, Spain., Martin J; GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, USA., McCloskey L; GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, USA., McCormick P; GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, USA., O'Keefe HP; GlaxoSmithKline, 830 Winter Street, Waltham, Massachusetts 02451, USA., O'Keeffe T; GlaxoSmithKline, 830 Winter Street, Waltham, Massachusetts 02451, USA., Pao C; GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, USA., Phelps CB; GlaxoSmithKline, 830 Winter Street, Waltham, Massachusetts 02451, USA., Qi H; GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, USA., Rafferty K; GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, USA., Scavello GS; GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, USA., Steiginga MS; GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, USA., Sundersingh FS; GlaxoSmithKline, 830 Winter Street, Waltham, Massachusetts 02451, USA., Sweitzer SM; GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, USA., Szewczuk LM; GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, USA., Taylor A; GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, USA., Toh MF; GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, USA., Wang J; GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, USA., Wang M; GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, USA., Wilkins DJ; GlaxoSmithKline, 830 Winter Street, Waltham, Massachusetts 02451, USA., Xia B; GlaxoSmithKline, 830 Winter Street, Waltham, Massachusetts 02451, USA., Yao G; GlaxoSmithKline, 830 Winter Street, Waltham, Massachusetts 02451, USA., Zhang J; GlaxoSmithKline, 830 Winter Street, Waltham, Massachusetts 02451, USA., Zhou J; GlaxoSmithKline, 830 Winter Street, Waltham, Massachusetts 02451, USA., Donahue CP; GlaxoSmithKline, 830 Winter Street, Waltham, Massachusetts 02451, USA., Messer JA; GlaxoSmithKline, 830 Winter Street, Waltham, Massachusetts 02451, USA., Holmes D; GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, USA., Arico-Muendel CC; GlaxoSmithKline, 830 Winter Street, Waltham, Massachusetts 02451, USA., Pope AJ; GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, USA., Gross JW; GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, USA., Evindar G; GlaxoSmithKline, 830 Winter Street, Waltham, Massachusetts 02451, USA.
Publikováno v:
Nature communications [Nat Commun] 2017 Jul 17; Vol. 8, pp. 16081. Date of Electronic Publication: 2017 Jul 17.
Autor:
Kapilashrami K; Department of Chemistry, Institute for Chemical Biology & Drug Discovery, Stony Brook University, Stony Brook, New York 11794, USA., Bommineni GR, Machutta CA, Kim P, Lai CT, Simmerling C, Picart F, Tonge PJ
Publikováno v:
The Journal of biological chemistry [J Biol Chem] 2013 Mar 01; Vol. 288 (9), pp. 6045-52. Date of Electronic Publication: 2013 Jan 10.
Autor:
Diaz E; Platform Technology and Science, GlaxoSmithKline, Collegeville, PA 19426, USA., Machutta CA, Chen S, Jiang Y, Nixon C, Hofmann G, Key D, Sweitzer S, Patel M, Wu Z, Creasy CL, Kruger RG, LaFrance L, Verma SK, Pappalardi MB, Le B, Van Aller GS, McCabe MT, Tummino PJ, Pope AJ, Thrall SH, Schwartz B, Brandt M
Publikováno v:
Journal of biomolecular screening [J Biomol Screen] 2012 Dec; Vol. 17 (10), pp. 1279-92. Date of Electronic Publication: 2012 Aug 17.
Autor:
Verma SK; Cancer Epigenetics Discovery Performance Unit, Oncology Research & Development, Protein Dynamics Discovery Performance Unit, Oncology Research & Development, and Platform Technology and Sciences, GlaxoSmithKline Pharmaceuticals , Collegeville, Pennsylvania 19426, United States., Tian X; Cancer Epigenetics Discovery Performance Unit, Oncology Research & Development, Protein Dynamics Discovery Performance Unit, Oncology Research & Development, and Platform Technology and Sciences, GlaxoSmithKline Pharmaceuticals , Collegeville, Pennsylvania 19426, United States., LaFrance LV; Cancer Epigenetics Discovery Performance Unit, Oncology Research & Development, Protein Dynamics Discovery Performance Unit, Oncology Research & Development, and Platform Technology and Sciences, GlaxoSmithKline Pharmaceuticals , Collegeville, Pennsylvania 19426, United States., Duquenne C; Cancer Epigenetics Discovery Performance Unit, Oncology Research & Development, Protein Dynamics Discovery Performance Unit, Oncology Research & Development, and Platform Technology and Sciences, GlaxoSmithKline Pharmaceuticals , Collegeville, Pennsylvania 19426, United States., Suarez DP; Cancer Epigenetics Discovery Performance Unit, Oncology Research & Development, Protein Dynamics Discovery Performance Unit, Oncology Research & Development, and Platform Technology and Sciences, GlaxoSmithKline Pharmaceuticals , Collegeville, Pennsylvania 19426, United States., Newlander KA; Cancer Epigenetics Discovery Performance Unit, Oncology Research & Development, Protein Dynamics Discovery Performance Unit, Oncology Research & Development, and Platform Technology and Sciences, GlaxoSmithKline Pharmaceuticals , Collegeville, Pennsylvania 19426, United States., Romeril SP; Cancer Epigenetics Discovery Performance Unit, Oncology Research & Development, Protein Dynamics Discovery Performance Unit, Oncology Research & Development, and Platform Technology and Sciences, GlaxoSmithKline Pharmaceuticals , Collegeville, Pennsylvania 19426, United States., Burgess JL; Cancer Epigenetics Discovery Performance Unit, Oncology Research & Development, Protein Dynamics Discovery Performance Unit, Oncology Research & Development, and Platform Technology and Sciences, GlaxoSmithKline Pharmaceuticals , Collegeville, Pennsylvania 19426, United States., Grant SW; Cancer Epigenetics Discovery Performance Unit, Oncology Research & Development, Protein Dynamics Discovery Performance Unit, Oncology Research & Development, and Platform Technology and Sciences, GlaxoSmithKline Pharmaceuticals , Collegeville, Pennsylvania 19426, United States., Brackley JA; Cancer Epigenetics Discovery Performance Unit, Oncology Research & Development, Protein Dynamics Discovery Performance Unit, Oncology Research & Development, and Platform Technology and Sciences, GlaxoSmithKline Pharmaceuticals , Collegeville, Pennsylvania 19426, United States., Graves AP; Cancer Epigenetics Discovery Performance Unit, Oncology Research & Development, Protein Dynamics Discovery Performance Unit, Oncology Research & Development, and Platform Technology and Sciences, GlaxoSmithKline Pharmaceuticals , Collegeville, Pennsylvania 19426, United States., Scherzer DA; Cancer Epigenetics Discovery Performance Unit, Oncology Research & Development, Protein Dynamics Discovery Performance Unit, Oncology Research & Development, and Platform Technology and Sciences, GlaxoSmithKline Pharmaceuticals , Collegeville, Pennsylvania 19426, United States., Shu A; Cancer Epigenetics Discovery Performance Unit, Oncology Research & Development, Protein Dynamics Discovery Performance Unit, Oncology Research & Development, and Platform Technology and Sciences, GlaxoSmithKline Pharmaceuticals , Collegeville, Pennsylvania 19426, United States., Thompson C; Cancer Epigenetics Discovery Performance Unit, Oncology Research & Development, Protein Dynamics Discovery Performance Unit, Oncology Research & Development, and Platform Technology and Sciences, GlaxoSmithKline Pharmaceuticals , Collegeville, Pennsylvania 19426, United States., Ott HM; Cancer Epigenetics Discovery Performance Unit, Oncology Research & Development, Protein Dynamics Discovery Performance Unit, Oncology Research & Development, and Platform Technology and Sciences, GlaxoSmithKline Pharmaceuticals , Collegeville, Pennsylvania 19426, United States., Aller GS; Cancer Epigenetics Discovery Performance Unit, Oncology Research & Development, Protein Dynamics Discovery Performance Unit, Oncology Research & Development, and Platform Technology and Sciences, GlaxoSmithKline Pharmaceuticals , Collegeville, Pennsylvania 19426, United States., Machutta CA; Cancer Epigenetics Discovery Performance Unit, Oncology Research & Development, Protein Dynamics Discovery Performance Unit, Oncology Research & Development, and Platform Technology and Sciences, GlaxoSmithKline Pharmaceuticals , Collegeville, Pennsylvania 19426, United States., Diaz E; Cancer Epigenetics Discovery Performance Unit, Oncology Research & Development, Protein Dynamics Discovery Performance Unit, Oncology Research & Development, and Platform Technology and Sciences, GlaxoSmithKline Pharmaceuticals , Collegeville, Pennsylvania 19426, United States., Jiang Y; Cancer Epigenetics Discovery Performance Unit, Oncology Research & Development, Protein Dynamics Discovery Performance Unit, Oncology Research & Development, and Platform Technology and Sciences, GlaxoSmithKline Pharmaceuticals , Collegeville, Pennsylvania 19426, United States., Johnson NW; Cancer Epigenetics Discovery Performance Unit, Oncology Research & Development, Protein Dynamics Discovery Performance Unit, Oncology Research & Development, and Platform Technology and Sciences, GlaxoSmithKline Pharmaceuticals , Collegeville, Pennsylvania 19426, United States., Knight SD; Cancer Epigenetics Discovery Performance Unit, Oncology Research & Development, Protein Dynamics Discovery Performance Unit, Oncology Research & Development, and Platform Technology and Sciences, GlaxoSmithKline Pharmaceuticals , Collegeville, Pennsylvania 19426, United States., Kruger RG; Cancer Epigenetics Discovery Performance Unit, Oncology Research & Development, Protein Dynamics Discovery Performance Unit, Oncology Research & Development, and Platform Technology and Sciences, GlaxoSmithKline Pharmaceuticals , Collegeville, Pennsylvania 19426, United States., McCabe MT; Cancer Epigenetics Discovery Performance Unit, Oncology Research & Development, Protein Dynamics Discovery Performance Unit, Oncology Research & Development, and Platform Technology and Sciences, GlaxoSmithKline Pharmaceuticals , Collegeville, Pennsylvania 19426, United States., Dhanak D; Cancer Epigenetics Discovery Performance Unit, Oncology Research & Development, Protein Dynamics Discovery Performance Unit, Oncology Research & Development, and Platform Technology and Sciences, GlaxoSmithKline Pharmaceuticals , Collegeville, Pennsylvania 19426, United States., Tummino PJ; Cancer Epigenetics Discovery Performance Unit, Oncology Research & Development, Protein Dynamics Discovery Performance Unit, Oncology Research & Development, and Platform Technology and Sciences, GlaxoSmithKline Pharmaceuticals , Collegeville, Pennsylvania 19426, United States., Creasy CL; Cancer Epigenetics Discovery Performance Unit, Oncology Research & Development, Protein Dynamics Discovery Performance Unit, Oncology Research & Development, and Platform Technology and Sciences, GlaxoSmithKline Pharmaceuticals , Collegeville, Pennsylvania 19426, United States., Miller WH; Cancer Epigenetics Discovery Performance Unit, Oncology Research & Development, Protein Dynamics Discovery Performance Unit, Oncology Research & Development, and Platform Technology and Sciences, GlaxoSmithKline Pharmaceuticals , Collegeville, Pennsylvania 19426, United States.
Publikováno v:
ACS medicinal chemistry letters [ACS Med Chem Lett] 2012 Oct 19; Vol. 3 (12), pp. 1091-6. Date of Electronic Publication: 2012 Oct 19 (Print Publication: 2012).
Autor:
Borgaro JG; Institute for Chemical Biology & Drug Discovery, Department of Chemistry, Stony Brook University, Stony Brook, New York 11794-3400, United States., Chang A, Machutta CA, Zhang X, Tonge PJ
Publikováno v:
Biochemistry [Biochemistry] 2011 Dec 13; Vol. 50 (49), pp. 10678-86. Date of Electronic Publication: 2011 Nov 17.
Autor:
Machutta CA; Institute for Chemical Biology and Drug Discovery, Department of Chemistry, Stony Brook University, Stony Brook, New York 11794-3400, USA., Bommineni GR, Luckner SR, Kapilashrami K, Ruzsicska B, Simmerling C, Kisker C, Tonge PJ
Publikováno v:
The Journal of biological chemistry [J Biol Chem] 2010 Feb 26; Vol. 285 (9), pp. 6161-9. Date of Electronic Publication: 2009 Dec 16.
Autor:
Luckner SR; Rudolf Virchow Center for Experimental Biomedicine, Institute for Structural Biology, University of Würzburg, Würzburg, Germany., Machutta CA, Tonge PJ, Kisker C
Publikováno v:
Structure (London, England : 1993) [Structure] 2009 Jul 15; Vol. 17 (7), pp. 1004-13.