Combining P301L and S320F tau variants produces a novel accelerated model of tauopathy.

Autor: Koller EJ; Department of Neuroscience, University of Florida, Gainesville, FL, USA.; Center for Translational Research in Neurodegenerative Disease, University of Florida, Gainesville, FL, USA., Gonzalez De La Cruz E; Center for Translational Research in Neurodegenerative Disease, University of Florida, Gainesville, FL, USA., Machula T; Center for Translational Research in Neurodegenerative Disease, University of Florida, Gainesville, FL, USA., Ibanez KR; Center for Translational Research in Neurodegenerative Disease, University of Florida, Gainesville, FL, USA., Lin WL; Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL, USA., Williams T; Department of Neuroscience, University of Florida, Gainesville, FL, USA.; Center for Translational Research in Neurodegenerative Disease, University of Florida, Gainesville, FL, USA., Riffe CJ; Center for Translational Research in Neurodegenerative Disease, University of Florida, Gainesville, FL, USA., Ryu D; Center for Translational Research in Neurodegenerative Disease, University of Florida, Gainesville, FL, USA., Strang KH; Department of Neuroscience, University of Florida, Gainesville, FL, USA.; Center for Translational Research in Neurodegenerative Disease, University of Florida, Gainesville, FL, USA., Liu X; Center for Translational Research in Neurodegenerative Disease, University of Florida, Gainesville, FL, USA., Janus C; Department of Neuroscience, University of Florida, Gainesville, FL, USA.; Center for Translational Research in Neurodegenerative Disease, University of Florida, Gainesville, FL, USA., Golde TE; Department of Neuroscience, University of Florida, Gainesville, FL, USA.; Center for Translational Research in Neurodegenerative Disease, University of Florida, Gainesville, FL, USA.; McKnight Brain Institute, University of Florida, Gainesville, FL, USA., Dickson D; Department of Neuroscience, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL, USA., Giasson BI; Department of Neuroscience, University of Florida, Gainesville, FL, USA.; Center for Translational Research in Neurodegenerative Disease, University of Florida, Gainesville, FL, USA.; McKnight Brain Institute, University of Florida, Gainesville, FL, USA., Chakrabarty P; Department of Neuroscience, University of Florida, Gainesville, FL, USA.; Center for Translational Research in Neurodegenerative Disease, University of Florida, Gainesville, FL, USA.; McKnight Brain Institute, University of Florida, Gainesville, FL, USA.

Publikováno v: Human molecular genetics [Hum Mol Genet] 2019 Oct 01; Vol. 28 (19), pp. 3255-3269.

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Inhibiting tau-induced elevated nSMase2 activity and ceramides is therapeutic in an Alzheimer's disease mouse model.

Autor: Tallon, Carolyn^1,2 (AUTHOR), Bell, Benjamin J.^1,2 (AUTHOR), Malvankar, Medhinee M.¹ (AUTHOR), Deme, Pragney² (AUTHOR), Nogueras-Ortiz, Carlos³ (AUTHOR), Eren, Erden³ (AUTHOR), Thomas, Ajit G.¹ (AUTHOR), Hollinger, Kristen R.¹ (AUTHOR), Pal, Arindom^1,2 (AUTHOR), Mustapic, Maja³ (AUTHOR), Huang, Meixiang^1,2 (AUTHOR), Coleman, Kaleem^1,4 (AUTHOR), Joe, Tawnjerae R.^1,4 (AUTHOR), Rais, Rana^1,2,5 (AUTHOR), Haughey, Norman J.^2,6,7 (AUTHOR) nhaughe1@jh.edu, Kapogiannis, Dimitrios^2,3 (AUTHOR) kapogiannisd@mail.nih.gov, Slusher, Barbara S.^1,2,5,6,8,9 (AUTHOR) bslusher@jhmi.edu

Publikováno v: Translational Neurodegeneration. 12/4/2023, Vol. 12 Issue 1, p1-20. 20p.

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