Zobrazeno 1 - 10
of 216
pro vyhledávání: '"Machteld N. Hylkema"'
Publikováno v:
Environment International, Vol 190, Iss , Pp 108833- (2024)
Background: Childhood exposure to polycyclic aromatic hydrocarbons (PAHs) or lead (Pb) is associated with epigenetic modifications. However, the effects of their co-exposures on IGF1 (Insulin-like growth factor 1) methylation and the potential role i
Externí odkaz:
https://doaj.org/article/cd394b0a2be84f7687557505311de41a
Autor:
Roderick H. J. de Hilster, Marjan A. Reinders-Luinge, Annemarie Schuil, Theo Borghuis, Martin C. Harmsen, Janette K. Burgess, Machteld N. Hylkema
Publikováno v:
Bioengineering, Vol 11, Iss 9, p 946 (2024)
Chronic obstructive pulmonary disease (COPD) is a chronic lung disease characterized by ongoing inflammation, impaired tissue repair, and aberrant interplay between airway epithelium and fibroblasts, resulting in an altered extracellular matrix (ECM)
Externí odkaz:
https://doaj.org/article/3df3b1d0ed8145518b10d63a49ca5e37
Autor:
Sabine Bartel, Justina C. Wolters, Hasnat Noor, Karim Rafie, Jiahua Fang, Benedikt Kirchner, Esther Nolte-′t Hoen, Michael W. Pfaffl, Steven Rutgers, Wim Timens, Maarten van den Berge, Machteld N. Hylkema
Publikováno v:
Cells, Vol 13, Iss 11, p 945 (2024)
Chronic obstructive pulmonary disease (COPD) is a progressive lung disease for which there is no cure. Accumulating research results suggest a role for extracellular vesicles (EVs) in the pathogenesis of COPD. This study aimed to uncover the involvem
Externí odkaz:
https://doaj.org/article/17a0e1b40c69407f9b113d33e5cde8e4
Autor:
Dan-Dan Wu, Andy T. Y. Lau, Yan-Ming Xu, Marjan Reinders-Luinge, Mihaly Koncz, Antal Kiss, Wim Timens, Marianne G. Rots, Machteld N. Hylkema
Publikováno v:
Epigenetics, Vol 18, Iss 1 (2023)
Ubiquitin carboxyl-terminal hydrolase L1 (UCHL1) is highly expressed in smokers, but little is known about the molecular mechanism of UCHL1 in airway epithelium and its possible role in affecting extracellular matrix (ECM) remodelling in the underlyi
Externí odkaz:
https://doaj.org/article/2a12fdb3945348458e0b03b9495d19c6
Autor:
Stefan Pfeiffer, Gregor Jatzlauk, Joni V. Lund, Eistine Boateng, Draginja Kovacevic, Machteld N. Hylkema, Sabine Bartel, Michael Schloter, Susanne Krauss‐Etschmann
Publikováno v:
Immunity, Inflammation and Disease, Vol 10, Iss 8, Pp n/a-n/a (2022)
Abstract Early life exposures to antibiotics negatively impact respiratory health and are associated with an increased risk of childhood asthma. It is explained that the lung is inclined to develop chronic inflammatory phenotypes due to early antibio
Externí odkaz:
https://doaj.org/article/8ae33708c5db439c936ee462304d7879
Autor:
Khosbayar Lkhagvadorj, Karolin F. Meyer, Laura P. Verweij, Wierd Kooistra, Marjan Reinders-Luinge, Henk W. Dijkhuizen, Inge A. M. de Graaf, Torsten Plösch, Machteld N. Hylkema
Publikováno v:
Epigenetics, Vol 15, Iss 12, Pp 1370-1385 (2020)
Prenatal smoke exposure (PSE) is a risk factor for nicotine dependence. One susceptibility gene for nicotine dependence is Cytochrome P450 (CYP) 2A6, an enzyme responsible for the conversion of nicotine to cotinine and nicotine clearance in the liver
Externí odkaz:
https://doaj.org/article/9c83266db7144cbbba7fce50a2335ecf
PAH exposure is associated with enhanced risk for pediatric dyslipidemia through serum SOD reduction
Publikováno v:
Environment International, Vol 145, Iss , Pp 106132- (2020)
Background: Exposure to polycyclic aromatic hydrocarbons (PAHs) is linked to abnormal lipid metabolism, but evidence regarding PAHs as risk factors for dyslipidemia is lacking. Objective: To investigate the respective role and interaction of PAH expo
Externí odkaz:
https://doaj.org/article/73748a05ee2e488aa8854993ac0e2d13
Autor:
Hataitip Tasena, Wim Timens, Maarten van den Berge, Joy van Broekhuizen, Brian K. Kennedy, Machteld N. Hylkema, Corry-Anke Brandsma, Irene H. Heijink
Publikováno v:
Cells, Vol 11, Iss 3, p 526 (2022)
We recently identified microRNAs (miRNAs) associated with chronic mucus hypersecretion (CMH) in chronic obstructive pulmonary disease (COPD), which were expressed in both airway epithelial cells and fibroblasts. We hypothesized that these miRNAs are
Externí odkaz:
https://doaj.org/article/b204f0832e2c480299332a852d4564ec
Publikováno v:
Environment International, Vol 139, Iss , Pp - (2020)
Background: Polycyclic aromatic hydrocarbons (PAHs), as a group of persistent organic pollutants, are linked to impaired immune function and low-grade inflammation in adults and children. However, the potential of PAHs to lead to a cytokine storm ass
Externí odkaz:
https://doaj.org/article/f4d7bed5e367454a9e35977054957ac3
Publikováno v:
Environment International, Vol 138, Iss , Pp - (2020)
Background: Exposure to atmospheric fine particle matter (PM2.5) pollution and the absorbed pollutants is known to contribute to numerous adverse health effects in children including to growth. Objective: The aim of this study was to evaluate exposur
Externí odkaz:
https://doaj.org/article/de079a1e57924b95948ea599bd754eaf