Protection against Marburg Virus and Sudan Virus in NHP by an Adenovector-Based Trivalent Vaccine Regimen Is Correlated to Humoral Immune Response Levels

Autor: Machteld M. Tiemessen, Laura Solforosi, Liesbeth Dekking, Dominika Czapska-Casey, Jan Serroyen, Nancy J. Sullivan, Ariane Volkmann, Maria Grazia Pau, Benoit Callendret, Hanneke Schuitemaker, Kerstin Luhn, Roland Zahn, Ramon Roozendaal

Publikováno v: Vaccines, Vol 10, Iss 8, p 1263 (2022)

The Marburg virus (MARV) and Sudan virus (SUDV) belong to the filovirus family. The sporadic human outbreaks occur mostly in Africa and are characterized by an aggressive disease course with high mortality. The first case of Marburg virus disease in

Externí odkaz: https://doaj.org/article/da2eb72a5deb4a68a93957d1fb5e72b3

Decreased Histone Acetylation Levels at Th1 and Regulatory Loci after Induction of Food Allergy

Autor: Bilal Alashkar Alhamwe, Laura A. P. M. Meulenbroek, Désirée H. Veening-Griffioen, Tjalling M. D. Wehkamp, Fahd Alhamdan, Sarah Miethe, Hani Harb, Astrid Hogenkamp, Léon M. J. Knippels, Elke Pogge von Strandmann, Harald Renz, Johan Garssen, Betty C. A. M. van Esch, Holger Garn, Daniel P. Potaczek, Machteld M. Tiemessen

Publikováno v: Nutrients, Vol 12, Iss 10, p 3193 (2020)

Immunoglobulin E (IgE)-mediated allergy against cow’s milk protein fractions such as whey is one of the most common food-related allergic disorders of early childhood. Histone acetylation is an important epigenetic mechanism, shown to be involved i

Externí odkaz: https://doaj.org/article/aab0e6eca7c94518a9ae8f2e07d217a0

Potential Biomarkers, Risk Factors, and Their Associations with IgE-Mediated Food Allergy in Early Life: A Narrative Review

Autor: Laurien H. Ulfman, Liisa Lehtoranta, Machteld M. Tiemessen, Maria Carmen Collado, Carlos Gómez-Gallego, Caroline E. Childs, Tobias Recker, Seppo Salminen, Daniel Munblit

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname

Food allergy affects the quality of life of millions of people worldwide and presents a significant psychological and financial burden for both national and international public health. In the past few decades, the prevalence of allergic disease has

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18c580c1f796401ddb52408436d4767e
https://doi.org/10.1093/advances/nmab122

Functional definition of a transcription factor hierarchy regulating T cell lineage commitment

Autor: David San Leon Granado, Machteld M. Tiemessen, Laura Garcia-Perez, Karin Pike-Overzet, Frank J. T. Staal, Farbod Famili, Marja C.J.A. van Eggermond, Haoyu Wu, Martijn Cordes, Jihed Chouaref, Lucia Daxinger, Martijn H. Brugman

Publikováno v: Science Advances, 6(31). AMER ASSOC ADVANCEMENT SCIENCE
Science Advances

The major transcription factors that regulate how stem cells commit to become T lymphocytes are functionally defined
T cell factor 1 (Tcf1) is the first T cell–specific protein induced by Notch signaling in the thymus, leading to the activatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d12675a50c74968cf01b24eb83d9993a
https://hdl.handle.net/1887/3182055

Management of Cow's Milk Allergy from an Immunological Perspective : What Are the Options?

Autor: Nicolette W. de Jong, Edward F. Knol, Laurien H. Ulfman, Machteld M. Tiemessen

Publikováno v: Nutrients, 11(11). Multidisciplinary Digital Publishing Institute (MDPI)
Nutrients
Nutrients, Vol 11, Iss 11, p 2734 (2019)
Nutrients, 11(11):2734. Multidisciplinary Digital Publishing Institute (MDPI)

The immunological mechanism underlying Immunoglobuline E (IgE)-mediated cow’s milk allergy has been subject to investigations for many years. Identification of the key immune cells (mast cells, B cells) and molecules (IgE) in the allergic process h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e35793069de1939397d623fd3d2f690
https://dspace.library.uu.nl/handle/1874/391714