Výsledky vyhledávání - "Machiko Nakanishi"

Identification of Metabolites of a New Thromboxane A2 Receptor Antagonist, S-1452, in Rats

Autor: Yuzo Nakagawa, Junko Kikuchi, Yoshihiro Terui, Kouji Iwatani, Takeo Yoshimori, Ryo Norikura, Kenji Mizojiri, Machiko Nakanishi

Publikováno v: Drug Metabolism and Pharmacokinetics. 8:67-81

The metabolism of S-1452, calcium (5Z)-7-[(1R, 2S, 3S, 4S)-3-phenylsulfonylaminobicyclo[2.2.1]hept-2-yl]-5-heptenoate hydrate, a new TXA2 receptor antagonist, in rats was studied. Twelve unconjugated metabolites including the unchanged free acid of S

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::00e0c5e1935d35964e0432607878680e
https://doi.org/10.2133/dmpk.8.67

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Studies on the Metabolic Fate of a New Thromboxane A2 Receptor Antagonist, S-1452. (II). Distribution and Excretion after Single and Repeated Oral Administration to Rats

Autor: Machiko Nakanishi, Shinya Futaguchi, Hiroshi Okabe, Yuka Iwamoto, Ryo Norikura, Kenji Mizojiri, Hideo Tanaka, Takeo Yoshimori

Publikováno v: Drug Metabolism and Pharmacokinetics. 8:97-105

The tissue distribution and excretion of S-1452 were studied in rats after a single and repeated oral administration of 14C-S-1452 at a dose of 5mg/kg or 5mg/kg/day for 10 days. 1. The level of radioactivity in the liver was markedly higher than thos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::271aea0c4d424d9a4de5e61a4ff9c35b
https://doi.org/10.2133/dmpk.8.97

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Studies on the Metabolic Fate of a New Thromboxane A2 Receptor Antagonist, S-1452. (III). Transfer into the Fetus and Milk in Rats

Autor: Yuka Iwamoto, Takeo Yoshimori, Kenji Mizojiri, Ryo Norikura, Machiko Nakanishi, Hideo Tanaka

Publikováno v: Drug Metabolism and Pharmacokinetics. 8:107-112

Transfer of radioactivity into the fetus and milk were studied after a single oral administration of 14C-S-1452 at a dose of 5mg/kg in pregnant rats on 19 days of gestation and in lactating rats. 1. In whole body autoradiography, distribution pattern

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cc5258ae4ea36da3fd7f8e05ae8b059c
https://doi.org/10.2133/dmpk.8.107

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Studies on the Metabolic Fate of a New Thromboxane A2 Receptor Antagonist, S-1452. (I). Absorption, Distribution, Metabolism and Excretion after Single Administration to Rats

Autor: Machiko Nakanishi, Kenji Mizojiri, Tsuyoshi Murakami, Ryo Norikura, Takeo Yoshimori

Publikováno v: Drug Metabolism and Pharmacokinetics. 8:83-96

The absorption, distribution, metabolism and excretion of S-1452, a new thromboxane A2 receptor antagonist, were studied after a single oral or intravenous administration of 14C-labelled compounds at a dose of 5mg/kg to fasted and non-fasted rats. Al

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e72b1b493bad35213f6ecc21f64e758a
https://doi.org/10.2133/dmpk.8.83

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Dynamic pH junction technique for on-line preconcentration of peptides in capillary electrophoresis

Autor: Jong-Bok Kim, Shigeru Terabe, Koshi Imami, Maria Rowena N. Monton, Machiko Nakanishi

Publikováno v: Journal of chromatography. A. 1079(1-2)

A method based on the presence of a dynamic pH junction within the capillary to induce band narrowing for enhanced detection sensitivity for some peptides is presented. This technique is predicated on a sharp reduction in an analyte's migration veloc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4651a9397fbc6f9da736821d28c7d85
https://pubmed.ncbi.nlm.nih.gov/16038313

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Separate assessment of intestinal and hepatic first-pass effects using a rat model with double cannulation of the portal and jugular veins

Autor: Kenji Mizojiri, Tsuyoshi Murakami, Machiko Nakanishi, Noboru Okamura, Ryo Norikura, Takeo Yoshimori

Publikováno v: Drug metabolism and pharmacokinetics. 18(4)

To separately assess intestinal and hepatic first-pass effects with absorption ratio data, we have established an experimental model of rats double-cannulated into the portal and jugular veins. The model allows us to take blood samples simultaneously

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0216672e67e4c8d411bbf0a3f6149be9
https://pubmed.ncbi.nlm.nih.gov/15618743

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Disposition of S-1108, a New Oral Cephem Antibiotic, and Metabolic Fate of Pivalic Acid Liberated from [ pivaloyl - 14 C]S-1108 in Rats and Dogs

Autor: Machiko Nakanishi, Yoshihiko Katsuyama, Kenji Mizojiri, Shinya Futaguchi, Ryo Norikura, Takeo Yoshimori, Tohru Nagasaki

Publikováno v: Antimicrob Agents Chemother

[pivaloyl-14C]S-1108, which is 14C labeled at the pivalic acid moiety of the pivaloyloxymethyl side chain of S-1108, was administered orally to rats and dogs, and the disposition of pivalic acid cleft from S-1108 was examined. Besides pivaloylcarniti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca488fc1f0aae8041e8f180b7a6f6455
https://doi.org/10.1128/aac.39.10.2373a

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[Pharmacology of a new sleep-inducer, a 1H-1,2,4-triazolyl benzophenone derivative, 450191-S (VIII). Examination and determination of metabolites in human plasma and urine]

Autor: Toshiro YAMAGUCHI, Machiko NAKANISHI, Meiko YAMASHITA, Hiromi MATSUMOTO, Masahiro NAKAMURA, Goro KOMINAMI, Kouji IWATANI, Yuzo NAKAGAWA, Masao KONO, Koichi SUGENO, Hiroshi FUKUDA

Publikováno v: Nihon yakurigaku zasshi. Folia pharmacologica Japonica. 90(4)

Oral administration of 450191-S to humans at 4 mg/man led to the formation of the same plasma metabolites as those found in animals; i.e., M-1, M-2, M-A, M-3 and M-4. Unlike in animals, M-4 was the major metabolite in human plasma for 6 hr after dosi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38197f614cab31609ac37a2c95fec830
https://pubmed.ncbi.nlm.nih.gov/3428781

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