Transient anti-cytokine autoantibodies superimpose the hyperinflammatory response in Kawasaki disease and multisystem inflammatory syndrome in children: a comparative cohort study on correlates of diseaseResearch in context

Autor: Stejara A. Netea, Giske Biesbroek, Diana van Stijn, Hanna Ijspeert, Caspar I. van der Made, Machiel H. Jansen, Judy Geissler, J.M. (Merlijn) van den Berg, Martijn van der Kuip, Mariken P. Gruppen, Dieneke Schonenberg-Meinema, Berber Kapitein, A.M. (Marceline) Tutu van Furth, Sietse Q. Nagelkerke, Dasja Pajkrt, Frans B. Plötz, M.E.J. (Lisette) den Boer, Gijs W. Landman, Marlies A. van Houten, Ines Goetschalckx, Erik J.M. Toonen, Frank L. van de Veerdonk, Irene M. Kuipers, Willem A. Dik, Taco W. Kuijpers, T. Hendriks, M.K. Felderhof, N.M. Weggelaar, L. Filippini, L. Rozendaal, M. Groeneweg, R. Nuboer, M. Bruijn, K.M. Dolman, J.G. Noordzij, J.P. de Winter, A.M. Vlieger, F.B. Plötz, L.C. Delemarre

Publikováno v: EBioMedicine, Vol 95, Iss , Pp 104736- (2023)

Summary: Background: Children with SARS-CoV-2 related Multisystem Inflammatory Syndrome in Children (MIS-C) often present with clinical features that resemble Kawasaki disease (KD). Disease severity in adult COVID-19 is associated to the presence of

Externí odkaz: https://doaj.org/article/93828e5e066e4179b2b6ff7905fc558a

Treatment of an HLH-mimic disease based on HAVCR2 variants with absent TIM-3 expression

Autor: Samantha A. M. Tromp, Marijn A. Gillissen, Sophie J. Bernelot Moens, Ester M. M. van Leeuwen, Machiel H. Jansen, Lianne Koens, Caroline E. Rutten, Taco W. Kuijpers

Publikováno v: Blood, 6(15), 4501-4505. American Society of Hematology
Tromp, S A M, Gillissen, M A, Bernelot Moens, S J, van Leeuwen, E M M, Jansen, M H, Koens, L, Rutten, C E & Kuijpers, T W 2022, ' Treatment of an HLH-mimic disease based on HAVCR2 variants with absent TIM-3 expression ', Blood, vol. 6, no. 15, pp. 4501-4505 . https://doi.org/10.1182/bloodadvances.2022007450
Blood advances, 6(15), 4501-4505. American Society of Hematology

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09e95baafaad3b563d8714067c4509f6
https://doi.org/10.1182/bloodadvances.2022007450

High-throughput compound screen reveals mTOR inhibitors as potential therapeutics to reduce (auto)antibody production by human plasma cells

Autor: Paul Tuijnenburg, Ester M. M. van Leeuwen, Cor Lieftink, Roderick L. Beijersbergen, Machiel H. Jansen, Taco W. Kuijpers, Daan J. aan de Kerk, Ben Morris

Publikováno v: European journal of immunology, 50(1), 73-85. Wiley-VCH Verlag
European Journal of Immunology

Antibody production by the B cell compartment is a crucial part of the adaptive immune response. Dysregulated antibody production in the form of autoantibodies can cause autoimmune disease. To date, B‐cell depletion with anti‐CD20 antibodies is c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::556cd75dbe1bf70f1c3de8414135808f
https://doi.org/10.1002/eji.201948241

A combined immunodeficiency with severe infections, inflammation, and allergy caused by ARPC1B deficiency

Autor: Jovanka R King, Cristina Bottino, Patrick Quinn, Alexander Blank, Asbjørg Stray-Pedersen, Michael Gold, Ulrich Pannicke, Emily M. Mace, Lisa R. Forbes, Marwan Abu-Halaweh, Eva-Maria Jacobsen, Anton T.J. Tool, Sabrina Chiesa, Roberta Caorsi, Marco Gattorno, Silvia Giliani, Stefano Volpi, Jordan S. Orange, Ivan K. Chinn, Taco W. Kuijpers, Immacolata Brigida, Hamid Ahanchian, Paul Tuijnenburg, Federica Barzaghi, Bertrand Boisson, Zeynep Coban Akdemir, Gregor Dückers, Chris Pearson, Machiel H. Jansen, Alexander B. Meijer, Maria Pia Cicalese, Ansgar Schulz, Filiz O. Seeborg, Eloy Cuadrado, Hasan Tawamie, Ehsan Ghayoor Karimiani, Jean-Laurent Casanova, Raed Alzyoud, Tomasz Gambin, Stefania Marcenaro, Luigi D. Notarangelo, Anselm Enders, Rae S. M. Yeung, Klaus Schwarz, Reza Maroofian, Hans Christian Erichsen, Paolo Picco, Ester M. M. van Leeuwen, Tim Niehues, Ronald M. Laxer, James R. Lupski, Alessandro Aiuti

Publikováno v: Journal of Allergy and Clinical Immunology, 143(6), 2296-2299. Mosby Inc.
Journal of allergy and clinical immunology, 143(6), 2296-2299. Mosby Inc.
Journal of Allergy and Clinical Immunology, 143(6), 2296. Mosby Inc.

We report the natural history, clinical manifestations, genetics, and immunohematological findings in 14 patients from 11 families with ARPC1B deficiency, delineating the spectrum of the disease that appears progressive and challenging to manage clin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c41993e3bdfd1b3e9e98ef6538a9100e
https://doi.org/10.1016/j.jaci.2019.02.003

A reversion of an IL2RG mutation in combined immunodeficiency providing competitive advantage to the majority of CD8+ T cells

Autor: Taco W. Kuijpers, Ester M.M. van Leeuwen, Barbara H. Barendregt, Paul Klarenbeek, Daan J. aan de Kerk, Paul A. Baars, Machiel H. Jansen, Niek de Vries, René A.W. van Lier, Mirjam van der Burg

Publikováno v: Haematologica, Vol 98, Iss 7 (2013)

Mutations in the common gamma chain (γc, CD132, encoded by the IL2RG gene) can lead to B+T−NK− X-linked severe combined immunodeficiency, as a consequence of unresponsiveness to γc-cytokines such as interleukins-2, -7 and -15. Hypomorphic mutat

Externí odkaz: https://doaj.org/article/3135c2c8e5d44233ad97b1a493673ae6