Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Machie Sakuma"'
Autor:
Akiko Hashimoto-Tane, Edward P. Bowman, Machie Sakuma, Natsumi Yoneda, Katsuyuki Yugi, Rene de Waal Malefyt, Takashi Saito
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Lymphocyte activation gene (Lag)-3 is an inhibitory co-receptor and target of immune checkpoint inhibitor (ICI) therapy for cancer. The dynamic behavior of Lag-3 was analyzed at the immune synapse upon T-cell activation to elucidate the Lag-3 inhibit
Externí odkaz:
https://doaj.org/article/01488bb5ac8c4a6ab38ab7b584d9ff15
Autor:
Masaru Takeshita, Hidehiro Fukuyama, Katsuhiko Kamada, Takehisa Matsumoto, Chieko Makino-Okamura, Qingshun Lin, Machie Sakuma, Eiki Kawahara, Isato Yamazaki, Tomomi Uchikubo-Kamo, Yuri Tomabechi, Kazuharu Hanada, Tamao Hisano, Saya Moriyama, Yoshimasa Takahashi, Mutsumi Ito, Masaki Imai, Tadashi Maemura, Yuri Furusawa, Seiya Yamayoshi, Yoshihiro Kawaoka, Mikako Shirouzu, Makoto Ishii, Hideyuki Saya, Yasushi Kondo, Yuko Kaneko, Katsuya Suzuki, Koichi Fukunaga, Tsutomu Takeuchi
Publikováno v:
iScience, Vol 26, Iss 6, Pp 106955- (2023)
Summary: Several antibody therapeutics have been developed against SARS-CoV-2; however, they have attenuated neutralizing ability against variants. In this study, we generated multiple broadly neutralizing antibodies from B cells of convalescents, by
Externí odkaz:
https://doaj.org/article/e2e3c31b08ae483eaf9d68617811b2ec
Autor:
Mei Suen Kong, Reiko Onishi, Nick Carpino, Tomohiro Kurosaki, Osamu Ohara, Yusuke Kawashima, Takashi Saito, Akiko Hashimoto-Tane, Machie Sakuma, Kohei Kometani, Tadashi Yokosuka, Kia Kien Phua
Publikováno v:
Science signaling. 12(567)
T cell activation is initiated by signaling molecules downstream of the T cell receptor (TCR) that are organized by adaptor proteins. CIN85 (Cbl-interacting protein of 85 kDa) is one such adaptor protein. Here, we showed that CIN85 limited T cell res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e88cdc7164eadb03526995d66de9f4ee
https://pubmed.ncbi.nlm.nih.gov/30723173
https://pubmed.ncbi.nlm.nih.gov/30723173
Autor:
Machie Sakuma, Hiroaki Tateno, Jun Uno, Yuzuru Mikami, Osamu Takeuchi, Tetsuhiro Matsuzawa, Shizuo Akira, Makoto Matsumoto, Takashi Saito, Jun Hirabayashi, Sho Yamasaki, Eri Ishikawa, Kiyoshi Takeda
Publikováno v:
Proceedings of the National Academy of Sciences. 106:1897-1902
Mincle (also called as Clec4e and Clecsf9) is a C-type lectin receptor expressed in activated phagocytes. Recently, we have demonstrated that Mincle is an FcRγ-associated activating receptor that senses damaged cells. To search an exogenous ligand(s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9079971516cd76a6978d69938e34d704
https://doi.org/10.1073/pnas.0805177106
https://doi.org/10.1073/pnas.0805177106
Autor:
Mitsuyo Takase-Utsugi, Machie Sakuma, Sho Yamasaki, Osami Kanagawa, Eri Ishikawa, Takashi Saito, Keigo Nishida
Publikováno v:
International Immunology. 20:1289-1297
Gads is a Grb2-like adaptor protein expressed in hematopoietic cells. We demonstrated that mast cells from Gads(-/-) mice have selective functional defects. Bone marrow-derived mast cells from Gads(-/-) mice failed to induce Ca(2+) mobilization, degr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95031ee96fa6ca8e4d4ce03ec975097d
https://doi.org/10.1093/intimm/dxn085
https://doi.org/10.1093/intimm/dxn085
Autor:
Akiko Hashimoto-Tane, Tadashi Yokosuka, Hiroshi Ike, Machie Sakuma, Osamu Ohara, Yayoi Kimura, Takashi Saito
Publikováno v:
The Journal of Experimental Medicine
Saito et al. describe a ring of focal adhesion molecules that surrounds T cell receptor microclusters and is essential for early T cell activation.
The immunological synapse (IS) formed at the interface between T cells and antigen-presenting cel
The immunological synapse (IS) formed at the interface between T cells and antigen-presenting cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82af6fdaab28dc004dfe2be85c283f44
https://pubmed.ncbi.nlm.nih.gov/27354546
https://pubmed.ncbi.nlm.nih.gov/27354546
Autor:
David L. Wiest, Machie Sakuma, Michio Hiroshima, Kumiko Sakata-Sogawa, Makio Tokunaga, Takashi Saito, Shou Yamasaki, Koji Ogata, Eri Ishikawa
Publikováno v:
nature immunology. 7(number 1):67-75
The pre-T cell receptor (TCR) is crucial for early T cell development and is proposed to function in a ligand-independent way. However, the molecular mechanism underlying the autonomous signals remains elusive. Here we show that the pre-TCR complex s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26b3691f3eec209df3b28f6470113437
http://t2r2.star.titech.ac.jp/cgi-bin/publicationinfo.cgi?q_publication_content_number=CTT100592722
http://t2r2.star.titech.ac.jp/cgi-bin/publicationinfo.cgi?q_publication_content_number=CTT100592722
Autor:
Chiaki Nakaseko, Machie Sakuma, Takehiko Fujisawa, Hiroshi Ohno, Takashi Saito, Hisashi Arase, Eiki Kominami, Mitsue Takeda-Ezaki, Tomohiko Iida
Publikováno v:
ResearcherID
CTLA-4 is expressed on the surface of activated T cells and negatively regulates T cell activation. Because a low-level expression of CTLA-4 on the cell surface is sufficient to induce negative signals in T cells, the surface expression of CTLA-4 is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dd760afafdc07138735e4dce3d843eb
https://doi.org/10.4049/jimmunol.165.9.5062
https://doi.org/10.4049/jimmunol.165.9.5062
Autor:
Fubito Nakatsu, Machie Sakuma, Hiroshi Ohno, Yo Matsuo, Nobuhiro Nakamura, Sho Yamasaki, Hisashi Arase, Takashi Saito
Publikováno v:
Journal of Biological Chemistry. 275:26213-26219
Some plasma membrane receptors in yeast are known to be internalized and degraded in lysosomes upon ligand-dependent ubiquitination. However, the role of ubiquitination in endocytosis and lysosomal degradation in higher eukaryotes has been controvers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1e1a981333c037f99cf85f6ac4bc3ad9
https://doi.org/10.1074/jbc.m907720199
https://doi.org/10.1074/jbc.m907720199
Publikováno v:
ResearcherID
Full activation of T cells with antigen (Ag) and antigen-presenting cells initiates effector functions and proliferation. When T cells are re-stimulated through the T cell receptor (TCR) after a primary stimulation with Ag, growth arrest and cell dea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26e0ceaa4db6504c2e45a501daa57125
https://doi.org/10.1002/eji.1830270733
https://doi.org/10.1002/eji.1830270733