Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Machender R. Kandadi"'
Autor:
Shuyi Wang, Jun Tao, Huaguo Chen, Machender R. Kandadi, Mingming Sun, Haixia Xu, Gary D. Lopaschuk, Yan Lu, Junmeng Zheng, Hu Peng, Jun Ren
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 11, Iss 11, Pp 3508-3526 (2021)
Given the opposing effects of Akt and AMP-activated protein kinase (AMPK) on metabolic homeostasis, this study examined the effects of deletion of Akt2 and AMPKα2 on fat diet-induced hepatic steatosis. Akt2–Ampkα2 double knockout (DKO) mice were
Externí odkaz:
https://doaj.org/article/9eeb02dc06cc42c9a49a107ebabdbf0d
Autor:
Shuyi Wang, Jun Tao, Huaguo Chen, Machender R. Kandadi, Mingming Sun, Haixia Xu, Gary D. Lopaschuk, Yan Lu, Junmeng Zheng, Hu Peng, Jun Ren
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 13, Iss 2, Pp 897-898 (2023)
Externí odkaz:
https://doaj.org/article/2d54bb860fe84b16aa1d632caddeb320
Autor:
Mingming Sun, Gary D. Lopaschuk, Huaguo Chen, Haixia Xu, Shuyi Wang, Jun Ren, Hu Peng, Yan Lu, Jun Tao, Junmeng Zheng, Machender R. Kandadi
Publikováno v:
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 11, Pp 3508-3526 (2021)
Acta Pharmaceutica Sinica B, Vol 11, Iss 11, Pp 3508-3526 (2021)
Given the opposing effects of Akt and AMP-activated protein kinase (AMPK) on metabolic homeostasis, this study examined the effects of deletion of Akt2 and AMPKα2 on fat diet-induced hepatic steatosis. Akt2–Ampkα2 double knockout (DKO) mice were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e2e64074d0d7faa1b9d2da70550a409
https://doi.org/10.1016/j.apsb.2021.07.006
https://doi.org/10.1016/j.apsb.2021.07.006
Publikováno v:
Biochim Biophys Acta Mol Basis Dis
Increased age often leads to a gradual deterioration in cardiac geometry and contractile function although the precise mechanism remains elusive. Both Akt and AMPK play an essential role in the maintenance of cardiac homeostasis. This study examined
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca6208c70a75668e250a5f6f640f9f88
https://doi.org/10.1016/j.bbadis.2018.08.011
https://doi.org/10.1016/j.bbadis.2018.08.011
Autor:
Jun Ren, Zhaohui Pei, Guangwei Li, Machender R. Kandadi, Yaguang Bi, Yan Gong, Shuyi Wang, Ne N. Wu, Jun Tao
Publikováno v:
Biochimica et biophysica acta. Molecular basis of disease. 1866(10)
High fat diet intake contributes to undesired cardiac geometric and functional changes although the underlying mechanism remains elusive. Akt and AMPK govern to cardiac homeostasis. This study examined the impact of deletion of Akt2 (main cardiac iso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccea207d63ffd5e1d5cb8c91ae5757f4
https://pubmed.ncbi.nlm.nih.gov/35717934
https://pubmed.ncbi.nlm.nih.gov/35717934
Autor:
Sreejayan Nair, Jie Chen, Jun Ren, Zhaohui Pei, Asli F. Ceylan, Machender R. Kandadi, Shuyi Wang, Yinan Hua
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1864:3339-3352
Endothelin (ET)-1 is implicated in the pathophysiology of cardiovascular diseases although its role in obesity anomalies has not been fully elucidated. This study was designed to examine the impact of ET-1 receptor A (ETA) ablation on obesity-induced
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::994f58d4046c822f22f65eba69092ec5
https://doi.org/10.1016/j.bbadis.2018.07.020
https://doi.org/10.1016/j.bbadis.2018.07.020
Autor:
Yinan Hua, Machender R. Kandadi, Peter W. Nathanielsz, Sreejayan Nair, Stephen P. Ford, Mei-Jun Zhu, Subat Turdi, Jun Ren
Publikováno v:
The Journal of Nutritional Biochemistry. 24:1982-1990
Maternal overnutrition is associated with predisposition of offspring to cardiovascular disease in later life. Since maternal overnutrition may promote fetal and placental inflammatory responses, we hypothesized that maternal overnutrition/obesity in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8af83a8ede37150e7a4f9e60a175385
https://doi.org/10.1016/j.jnutbio.2013.07.003
https://doi.org/10.1016/j.jnutbio.2013.07.003
Publikováno v:
Current Pharmaceutical Design. 19:4874-4887
This study was designed to evaluate the role of ULK1 in AMPK-mediated myocardial autophagy and contractile dysfunction following acute alcohol challenge. Wild-type and AMPK knockout mice were challenged with ethanol (3 g/kg/d, i.p.) for 3 days. Myoca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04e905ab8e6864645508de8a6b293d4e
https://doi.org/10.2174/1381612811319270010
https://doi.org/10.2174/1381612811319270010
Publikováno v:
British Journal of Pharmacology. 167:612-626
BACKGROUND AND PURPOSE Anthrax lethal toxin (LeTx) is known to induce circulatory shock and death, although the underlying mechanisms have not been elucidated. This study was designed to evaluate the role of toll-like receptor 4 (TLR4) in anthrax let
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::14590d7a0276db4c26e8bd565f8c370c
https://doi.org/10.1111/j.1476-5381.2012.02040.x
https://doi.org/10.1111/j.1476-5381.2012.02040.x
Publikováno v:
Experimental Diabetes Research
Experimental Diabetes Research, Vol 2012 (2012)
Experimental Diabetes Research, Vol 2012 (2012)
(1) Hyperglycemia leads to cytotoxicity in the heart. Although several theories are postulated for glucose toxicity-induced cardiomyocyte dysfunction, the precise mechanism still remains unclear. (2) This study was designed to evaluate the impact of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f092c4f0aad36b031ae407242c069a96
https://doi.org/10.1155/2012/829758
https://doi.org/10.1155/2012/829758