Zobrazeno 1 - 10
of 105
pro vyhledávání: '"Macharouthu A"'
Autor:
Lindesay James, Knapp Martin, Jones Roy, Johnson Tony, Jacoby Robin, Hughes Alan, Holmes Clive, Griffin Mary, Gray Richard, Findlay David, Dening Tom, Burns Alistair, Brown Richard, Bentham Peter, Barber Bob, Banerjee Sube, Ballard Clive, Adams Jessica, Baldwin Ashley, Juszczak Ed, Phillips Patrick, Sheehan Bart, Jones Rob, McKeith Ian, McShane Rupert, Macharouthu Ajay, O'Brien John, Onions Caroline, Passmore Peter, Raftery James, Ritchie Craig, Howard Rob
Publikováno v:
Trials, Vol 10, Iss 1, p 57 (2009)
Abstract Background Alzheimer's disease (AD) is the commonest cause of dementia. Cholinesterase inhibitors, such as donepezil, are the drug class with the best evidence of efficacy, licensed for mild to moderate AD, while the glutamate antagonist mem
Externí odkaz:
https://doaj.org/article/f124176ba3634d4883815f7773527e19
Autor:
Harkness, Kirsty, Kuruvilla, Tarun, McShane, Rupert, Connelly, Peter, Duncan, Gordon, Calvert, Lucy, Lawrie, Alasdair, Sheridan, Matthew, Jackson, Eric, Udeze, Bernard, Pearson, Stephen, Langheinrich, Tobias, Wagle, Suvarna, Butchart, Joseph, Macharouthu, Ajay, Donaldson, Andrew, Neil, Wendy, Pattan, Vivek, Findlay, David, Thomas, Alan, Barber, Robert, Byrne, Andrew, Dalvi, Madhusudan, Negi, Rashi, McGuinness, Bernadette, Kehoe, Patrick Gavin *, Turner, Nicholas, Howden, Beth, Jarutyte, Lina, Clegg, Shona Louise, Malone, Ian Brian, Barnes, Josephine, Nielsen, Casper, Sudre, Carole Hélène, Wilson, Aileen, Thai, Ngoc Jade, Blair, Peter Sinclair, Coulthard, Elizabeth, Lane, Janet Athene, Passmore, Peter, Taylor, Jodi, Mutsaerts, Henk-Jan, Thomas, David Lee, Fox, Nick Charles, Wilkinson, Ian, Ben-Shlomo, Yoav
Publikováno v:
In The Lancet Neurology November 2021 20(11):895-906
Autor:
Grazia Daniela Femminella, Nicholas R. Livingston, Sanara Raza, Thalia van der Doef, Eleni Frangou, Sharon Love, Gail Busza, Valeria Calsolaro, Stefan Carver, Clive Holmes, Craig W. Ritchie, Robert M. Lawrence, Brady McFarlane, George Tadros, Basil H. Ridha, Carol Bannister, Zuzana Walker, Hilary Archer, Elizabeth Coulthard, Ben Underwood, Aparna Prasanna, Paul Koranteng, Salman Karim, Kehinde Junaid, Bernadette McGuinness, Anthony Peter Passmore, Ramin Nilforooshan, Ajayverma Macharouthu, Andrew Donaldson, Simon Thacker, Gregor Russell, Naghma Malik, Vandana Mate, Lucy Knight, Sajeev Kshemendran, Tricia Tan, Christian Holscher, John Harrison, David J. Brooks, Clive Ballard, Paul Edison
Publikováno v:
Alzheimer’s Research & Therapy, Vol 13, Iss 1, Pp 1-11 (2021)
Abstract Background Type 2 diabetes is a risk factor for Alzheimer’s disease (AD), and AD brain shows impaired insulin signalling. The role of peripheral insulin resistance on AD aetiopathogenesis in non-diabetic patients is still debated. Here we
Externí odkaz:
https://doaj.org/article/a198863d79fc4206ad26cdc93baa3fb5
Autor:
Grazia Daniela Femminella, Eleni Frangou, Sharon B. Love, Gail Busza, Clive Holmes, Craig Ritchie, Robert Lawrence, Brady McFarlane, George Tadros, Basil H. Ridha, Carol Bannister, Zuzana Walker, Hilary Archer, Elizabeth Coulthard, Ben R. Underwood, Aparna Prasanna, Paul Koranteng, Salman Karim, Kehinde Junaid, Bernadette McGuinness, Ramin Nilforooshan, Ajay Macharouthu, Andrew Donaldson, Simon Thacker, Gregor Russell, Naghma Malik, Vandana Mate, Lucy Knight, Sajeev Kshemendran, John Harrison, David J. Brooks, Anthony Peter Passmore, Clive Ballard, Paul Edison
Publikováno v:
Trials, Vol 20, Iss 1, Pp 1-10 (2019)
Abstract Background Liraglutide is a glucagon-like peptide-1 (GLP-1) analogue currently approved for type 2 diabetes and obesity. Preclinical evidence in transgenic models of Alzheimer’s disease suggests that liraglutide exerts neuroprotective effe
Externí odkaz:
https://doaj.org/article/3a0e309bbdd6411c977edcbdc27ca743
Autor:
Howard, Robert, Cort, Elizabeth, Bradley, Rosie, Harper, Emma, Kelly, Linda, Bentham, Peter, Ritchie, Craig, Reeves, Suzanne, Fawzi, Waleed, Livingston, Gill, Sommerlad, Andrew, Oomman, Sabu, Nazir, Ejaz, Nilforooshan, Ramin, Barber, Robert, Fox, Chris, Macharouthu, Ajay Verma, Ramachandra, Pranathi, Pattan, Vivek, Sykes, John, Curran, Val, Katona, Cornelius, Dening, Tom, Knapp, Martin, Gray, Richard
Publikováno v:
In The Lancet Psychiatry July 2018 5(7):553-563
Akademický článek
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Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Patrick Gavin Kehoe, Nicholas Turner, Beth Howden, Lina Jarutyte, Shona Louise Clegg, Ian Brian Malone, Josephine Barnes, Casper Nielsen, Carole Hélène Sudre, Aileen Wilson, Ngoc Jade Thai, Peter Sinclair Blair, Elizabeth Coulthard, Janet Athene Lane, Peter Passmore, Jodi Taylor, Henk-Jan Mutsaerts, David Lee Thomas, Nick Charles Fox, Ian Wilkinson, Yoav Ben-Shlomo, Kirsty Harkness, Tarun Kuruvilla, Rupert McShane, Peter Connelly, Gordon Duncan, Lucy Calvert, Alasdair Lawrie, Matthew Sheridan, Eric Jackson, Bernard Udeze, Stephen Pearson, Tobias Langheinrich, Suvarna Wagle, Joseph Butchart, Ajay Macharouthu, Andrew Donaldson, Wendy Neil, Vivek Pattan, David Findlay, Alan Thomas, Robert Barber, Andrew Byrne, Madhusudan Dalvi, Rashi Negi, Bernadette McGuinness
Publikováno v:
The Lancet. Neurology
Lancet Neurology, 20(11), 895-906. Lancet Publishing Group
Kehoe, P G, Turner, N, Howden, B, Jarutyte, L, Clegg, S L, Malone, I B, Barnes, J, Nielsen, C, Sudre, C H, Wilson, A, Thai, N J, Blair, P S, Coulthard, E, Lane, J A, Passmore, P, Taylor, J, Mutsaerts, H-J, Thomas, D L, Fox, N C, Wilkinson, I, Ben-Shlomo, Y & RADAR investigators 2021, ' Safety and efficacy of losartan for the reduction of brain atrophy in clinically diagnosed Alzheimer's disease (the RADAR trial) : a double-blind, randomised, placebo-controlled, phase 2 trial ', Lancet Neurology, vol. 20, no. 11, pp. 895-906 . https://doi.org/10.1016/S1474-4422(21)00263-5
RADAR investigators 2021, ' Safety and efficacy of losartan for the reduction of brain atrophy in clinically diagnosed Alzheimer's disease (the RADAR trial): a double-blind, randomised, placebo-controlled, phase 2 trial ', The Lancet. Neurology, vol. 20, no. 11, pp. 895-906 . https://doi.org/10.1016/S1474-4422(21)00263-5
2021, ' Safety and efficacy of losartan for the reduction of brain atrophy in clinically diagnosed Alzheimer's disease (the RADAR trial) : a double-blind, randomised, placebo-controlled, phase 2 trial ', Lancet Neurology, vol. 20, no. 11, pp. 895-906 . https://doi.org/10.1016/S1474-4422(21)00263-5
Kehoe, P G, Turner, N, Howden, B, Jarutyte, L, Clegg, S L, Malone, I B, Barnes, J, Nielsen, C, Sudre, C H, Wilson, A, Thai, N J, Blair, P S, Coulthard, E, Lane, J A, Passmore, P, Taylor, J, Mutsaerts, H-J, Thomas, D L, Fox, N C, Wilkinson, I & Ben-Shlomo, Y 2021, ' Safety and efficacy of losartan for the reduction of brain atrophy in clinically diagnosed Alzheimer's disease (the RADAR trial): a double-blind, randomised, placebo-controlled, phase 2 trial ', Lancet Neurology, vol. 20, no. 11, pp. 895-906 .
Lancet Neurology, 20(11), 895-906. Lancet Publishing Group
Kehoe, P G, Turner, N, Howden, B, Jarutyte, L, Clegg, S L, Malone, I B, Barnes, J, Nielsen, C, Sudre, C H, Wilson, A, Thai, N J, Blair, P S, Coulthard, E, Lane, J A, Passmore, P, Taylor, J, Mutsaerts, H-J, Thomas, D L, Fox, N C, Wilkinson, I, Ben-Shlomo, Y & RADAR investigators 2021, ' Safety and efficacy of losartan for the reduction of brain atrophy in clinically diagnosed Alzheimer's disease (the RADAR trial) : a double-blind, randomised, placebo-controlled, phase 2 trial ', Lancet Neurology, vol. 20, no. 11, pp. 895-906 . https://doi.org/10.1016/S1474-4422(21)00263-5
RADAR investigators 2021, ' Safety and efficacy of losartan for the reduction of brain atrophy in clinically diagnosed Alzheimer's disease (the RADAR trial): a double-blind, randomised, placebo-controlled, phase 2 trial ', The Lancet. Neurology, vol. 20, no. 11, pp. 895-906 . https://doi.org/10.1016/S1474-4422(21)00263-5
2021, ' Safety and efficacy of losartan for the reduction of brain atrophy in clinically diagnosed Alzheimer's disease (the RADAR trial) : a double-blind, randomised, placebo-controlled, phase 2 trial ', Lancet Neurology, vol. 20, no. 11, pp. 895-906 . https://doi.org/10.1016/S1474-4422(21)00263-5
Kehoe, P G, Turner, N, Howden, B, Jarutyte, L, Clegg, S L, Malone, I B, Barnes, J, Nielsen, C, Sudre, C H, Wilson, A, Thai, N J, Blair, P S, Coulthard, E, Lane, J A, Passmore, P, Taylor, J, Mutsaerts, H-J, Thomas, D L, Fox, N C, Wilkinson, I & Ben-Shlomo, Y 2021, ' Safety and efficacy of losartan for the reduction of brain atrophy in clinically diagnosed Alzheimer's disease (the RADAR trial): a double-blind, randomised, placebo-controlled, phase 2 trial ', Lancet Neurology, vol. 20, no. 11, pp. 895-906 .
BACKGROUND: Drugs modifying angiotensin II signalling could reduce Alzheimer's disease pathology, thus decreasing the rate of disease progression. We investigated whether the angiotensin II receptor antagonist losartan, compared with placebo, could r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4a28429bb9f725cd7e59ecafb894961
http://europepmc.org/articles/PMC8528717
http://europepmc.org/articles/PMC8528717
Autor:
Stefan Carver, Naghma Malik, Craig W. Ritchie, Sanara Raza, John E Harrison, Salman Karim, Gregor Russell, David J. Brooks, Clive Holmes, George Tadros, Gail Busza, Vandana Mate, Sajeev Kshemendran, Anthony Peter Passmore, Basil H. Ridha, Thalia van der Doef, Lucy Knight, Kehinde Junaid, Elizabeth Coulthard, Ben Underwood, Hilary Archer, Tricia Tan, Sharon Love, Zuzana Walker, Paul Koranteng, Ajayverma Macharouthu, Bernadette McGuinness, Andrew Donaldson, Simon Thacker, Clive Ballard, Grazia Daniela Femminella, Paul Edison, Valeria Calsolaro, Aparna Prasanna, Ramin Nilforooshan, Nicholas R Livingston, Christian Hölscher, Robert M. Lawrence, Carol Bannister, Brady McFarlane, Eleni Frangou
Publikováno v:
Femminella, G D, Livingston, N R, Raza, S, van der Doef, T, Frangou, E, Love, S, Busza, G, Calsolaro, V, Carver, S, Holmes, C, Ritchie, C W, Lawrence, R M, McFarlane, B, Tadros, G, Ridha, B H, Bannister, C, Walker, Z, Archer, H, Coulthard, E, Underwood, B, Prasanna, A, Koranteng, P, Karim, S, Junaid, K, McGuinness, B, Passmore, A P, Nilforooshan, R, Macharouthu, A, Donaldson, A, Thacker, S, Russell, G, Malik, N, Mate, V, Knight, L, Kshemendran, S, Tan, T, Holscher, C, Harrison, J, Brooks, D J, Ballard, C & Edison, P 2021, ' Does insulin resistance influence neurodegeneration in non-diabetic Alzheimer's subjects? ', Alzheimer's Research and Therapy, vol. 13, 47 (2021) . https://doi.org/10.1186/s13195-021-00784-w
Alzheimer's Research & Therapy
Alzheimer’s Research & Therapy, Vol 13, Iss 1, Pp 1-11 (2021)
Femminella, G D, Livingston, N R, Raza, S, Van Der Doef, T, Frangou, E, Love, S, Busza, G, Calsolaro, V, Carver, S, Holmes, C, Ritchie, C W, Lawrence, R M, Mcfarlane, B, Tadros, G, Ridha, B H, Bannister, C, Walker, Z, Archer, H, Coulthard, E, Underwood, B, Prasanna, A, Koranteng, P, Karim, S, Junaid, K, Mcguinness, B, Passmore, A P, Nilforooshan, R, Macharouthu, A, Donaldson, A, Thacker, S, Russell, G, Malik, N, Mate, V, Knight, L, Kshemendran, S, Tan, T, Holscher, C, Harrison, J, Brooks, D J, Ballard, C & Edison, P 2021, ' Does insulin resistance influence neurodegeneration in non-diabetic Alzheimer’s subjects? ', Alzheimer's research & therapy, vol. 13, no. 1 . https://doi.org/10.1186/s13195-021-00784-w
Femminella, G D, Livingston, N R, Raza, S, van der Doef, T, Frangou, E, Love, S, Busza, G, Calsolaro, V, Carver, S, Holmes, C, Ritchie, C W, Lawrence, R M, McFarlane, B, Tadros, G, Ridha, B H, Bannister, C, Walker, Z, Archer, H, Coulthard, E, Underwood, B, Prasanna, A, Koranteng, P, Karim, S, Junaid, K, McGuinness, B, Passmore, A P, Nilforooshan, R, Macharouthu, A, Donaldson, A, Thacker, S, Russell, G, Malik, N, Mate, V, Knight, L, Kshemendran, S, Tan, T, Holscher, C, Harrison, J, Brooks, D J, Ballard, C & Edison, P 2021, ' Does insulin resistance influence neurodegeneration in non-diabetic Alzheimer's subjects? ', Alzheimer's Research & Therapy, vol. 13, no. 1, pp. 47 . https://doi.org/10.1186/s13195-021-00784-w
Femminella, G D, Livingston, N R, Raza, S, van der Doef, T, Frangou, E, Love, S, Busza, G, Calsolaro, V, Carver, S, Holmes, C, Ritchie, C W, Lawrence, R M, McFarlane, B, Tadros, G, Ridha, B H, Bannister, C, Walker, Z, Archer, H, Coulthard, E, Underwood, B, Prasanna, A, Koranteng, P, Karim, S, Junaid, K, McGuinness, B, Passmore, A P, Nilforooshan, R, Macharouthu, A, Donaldson, A, Thacker, S, Russell, G, Malik, N, Mate, V, Knight, L, Kshemendran, S, Tan, T, Holscher, C, Harrison, J, Brooks, D J, Ballard, C & Edison, P 2021, ' Does insulin resistance influence neurodegeneration in non-diabetic Alzheimer's subjects? ', Alzheimer's research & therapy, vol. 13, 47 . https://doi.org/10.1186/s13195-021-00784-w
Alzheimer's Research & Therapy
Alzheimer’s Research & Therapy, Vol 13, Iss 1, Pp 1-11 (2021)
Femminella, G D, Livingston, N R, Raza, S, Van Der Doef, T, Frangou, E, Love, S, Busza, G, Calsolaro, V, Carver, S, Holmes, C, Ritchie, C W, Lawrence, R M, Mcfarlane, B, Tadros, G, Ridha, B H, Bannister, C, Walker, Z, Archer, H, Coulthard, E, Underwood, B, Prasanna, A, Koranteng, P, Karim, S, Junaid, K, Mcguinness, B, Passmore, A P, Nilforooshan, R, Macharouthu, A, Donaldson, A, Thacker, S, Russell, G, Malik, N, Mate, V, Knight, L, Kshemendran, S, Tan, T, Holscher, C, Harrison, J, Brooks, D J, Ballard, C & Edison, P 2021, ' Does insulin resistance influence neurodegeneration in non-diabetic Alzheimer’s subjects? ', Alzheimer's research & therapy, vol. 13, no. 1 . https://doi.org/10.1186/s13195-021-00784-w
Femminella, G D, Livingston, N R, Raza, S, van der Doef, T, Frangou, E, Love, S, Busza, G, Calsolaro, V, Carver, S, Holmes, C, Ritchie, C W, Lawrence, R M, McFarlane, B, Tadros, G, Ridha, B H, Bannister, C, Walker, Z, Archer, H, Coulthard, E, Underwood, B, Prasanna, A, Koranteng, P, Karim, S, Junaid, K, McGuinness, B, Passmore, A P, Nilforooshan, R, Macharouthu, A, Donaldson, A, Thacker, S, Russell, G, Malik, N, Mate, V, Knight, L, Kshemendran, S, Tan, T, Holscher, C, Harrison, J, Brooks, D J, Ballard, C & Edison, P 2021, ' Does insulin resistance influence neurodegeneration in non-diabetic Alzheimer's subjects? ', Alzheimer's Research & Therapy, vol. 13, no. 1, pp. 47 . https://doi.org/10.1186/s13195-021-00784-w
Femminella, G D, Livingston, N R, Raza, S, van der Doef, T, Frangou, E, Love, S, Busza, G, Calsolaro, V, Carver, S, Holmes, C, Ritchie, C W, Lawrence, R M, McFarlane, B, Tadros, G, Ridha, B H, Bannister, C, Walker, Z, Archer, H, Coulthard, E, Underwood, B, Prasanna, A, Koranteng, P, Karim, S, Junaid, K, McGuinness, B, Passmore, A P, Nilforooshan, R, Macharouthu, A, Donaldson, A, Thacker, S, Russell, G, Malik, N, Mate, V, Knight, L, Kshemendran, S, Tan, T, Holscher, C, Harrison, J, Brooks, D J, Ballard, C & Edison, P 2021, ' Does insulin resistance influence neurodegeneration in non-diabetic Alzheimer's subjects? ', Alzheimer's research & therapy, vol. 13, 47 . https://doi.org/10.1186/s13195-021-00784-w
Background Type 2 diabetes is a risk factor for Alzheimer’s disease (AD), and AD brain shows impaired insulin signalling. The role of peripheral insulin resistance on AD aetiopathogenesis in non-diabetic patients is still debated. Here we evaluated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abff61b5a79367e8f0ad4dae69e46610
https://research-information.bris.ac.uk/ws/files/277990943/s13195_021_00784_w.pdf
https://research-information.bris.ac.uk/ws/files/277990943/s13195_021_00784_w.pdf
Autor:
Paul Edison, Grazia Daniela Femminella, Craig W. Ritchie, Clive Holmes, Zuzana Walker, Basil H Ridha, Sanara Raza, Nicholas R Livingston, Joseph Nowell, Gail Busza, Eleni Frangou, Sharon Love, Gareth Williams, Robert M Lawrence, Brady McFarlane, Hilary Archer, Elizabeth Coulthard, Ben Underwood, Paul Koranteng, Salman Karim, Carol Bannister, Robert Perneczky, Aparna Prasanna, Kehinde Junaid, Bernadette McGuinness, Ramin Nilforooshan, Ajayverma Macharouthu, Andrew Donaldson, Simon Thacker, Gregor Russell, Naghma Malik, Vandana Mate, Lucy Knight, Sajeev Kshemendran, Christian Holscher, Anita Mansouri, Mae Chester‐Jones, Jane Holmes, Steven CR Williams, David J Brooks, John E Harrison, George Tadros, Anthony Peter Passmore, Clive Ballard
Publikováno v:
Alzheimer's & Dementia. 17
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fd8ab431967959e2094f0ccf0b38f90e
https://doi.org/10.1002/alz.057848
https://doi.org/10.1002/alz.057848