Benzenesulfonohydrazide-tethered non-fused and fused heterocycles as potential anti-mycobacterial agents targeting enoyl acyl carrier protein reductase (InhA) with antibiofilm activity.

Autor: Al-Warhi T; Department of Chemistry, College of Science, Princess Nourah bint Abdulrahman University Riyadh Saudi Arabia., Sabt A; Chemistry of Natural Compounds Department, Pharmaceutical and Drug Industries Research Institute, National Research Centre Dokki Cairo 12622 Egypt., Korycka-Machala M; Laboratory of Genetics and Physiology of Mycobacterium, Institute of Medical Biology of the Polish Academy of Sciences Lodz Poland jdziadek@cbm.pan.pl., Kassem AF; Department of Chemistry, College of Science and Humanities in Al-Kharj, Prince Sattam Bin Abdulaziz University Al-Kharj 11942 Saudi Arabia., Shaldam MA; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Kafrelsheikh University Kafrelsheikh 33516 Egypt wagdy2000@gmail.com., Ibrahim HAA; Pediatric Department, Faculty of Medicine, Cairo University Cairo Egypt., Kawka M; Department of Molecular Microbiology, Faculty of Biology and Environmental Protection, University of Lodz Lodz Poland., Dziadek B; Department of Molecular Microbiology, Faculty of Biology and Environmental Protection, University of Lodz Lodz Poland., Kuzioła M; Laboratory of Genetics and Physiology of Mycobacterium, Institute of Medical Biology of the Polish Academy of Sciences Lodz Poland jdziadek@cbm.pan.pl.; Bio-Med-Chem Doctoral School of the University of Lodz and Lodz Institutes of the Polish Academy of Sciences Lodz Poland., Eldehna WM; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Kafrelsheikh University Kafrelsheikh 33516 Egypt wagdy2000@gmail.com.; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Pharos University in Alexandria Canal El Mahmoudia St. Alexandria 21648 Egypt., Dziadek J; Laboratory of Genetics and Physiology of Mycobacterium, Institute of Medical Biology of the Polish Academy of Sciences Lodz Poland jdziadek@cbm.pan.pl.

Publikováno v: RSC advances [RSC Adv] 2024 Sep 23; Vol. 14 (41), pp. 30165-30179. Date of Electronic Publication: 2024 Sep 23 (Print Publication: 2024).

New coumarin linked thiazole derivatives as antimycobacterial agents: Design, synthesis, enoyl acyl carrier protein reductase (InhA) inhibition and molecular modeling.

Autor: Kassem AF; Chemistry of Natural and Microbial Products Department, Pharmaceutical and Drug Industries Research Institute, National Research Centre, Dokki, Cairo 12622, Egypt., Sabt A; Chemistry of Natural Compounds Department, Pharmaceutical and Drug Industries Research Institute, National Research Centre, Dokki, Cairo 12622, Egypt., Korycka-Machala M; Laboratory of Genetics and Physiology of Mycobacterium, Institute of Medical Biology of the Polish Academy of Sciences, Lodz, Poland., Shaldam MA; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Kafrelsheikh University, Kafrelsheikh 33516, Egypt., Kawka M; Department of Molecular Microbiology, Faculty of Biology and Environmental Protection, University of Lodz, Lodz, Poland., Dziadek B; Department of Molecular Microbiology, Faculty of Biology and Environmental Protection, University of Lodz, Lodz, Poland., Kuzioła M; Laboratory of Genetics and Physiology of Mycobacterium, Institute of Medical Biology of the Polish Academy of Sciences, Lodz, Poland; Bio-Med-Chem Doctoral School of the University of Lodz and Lodz Institutes of the Polish Academy of Sciences, Lodz, Poland., Dziadek J; Laboratory of Genetics and Physiology of Mycobacterium, Institute of Medical Biology of the Polish Academy of Sciences, Lodz, Poland. Electronic address: jdziadek@cbm.pan.pl., Batran RZ; Chemistry of Natural Compounds Department, Pharmaceutical and Drug Industries Research Institute, National Research Centre, Dokki, Cairo 12622, Egypt. Electronic address: rasha_batran@yahoo.com.

Publikováno v: Bioorganic chemistry [Bioorg Chem] 2024 Sep; Vol. 150, pp. 107511. Date of Electronic Publication: 2024 May 31.

Transcriptional and phenotypical alterations associated with a gradual benzo[a]pyrene-induced transition of human bronchial epithelial cells into mesenchymal-like cells.

Autor: Hýžďalová M; Department of Pharmacology and Toxicology, Veterinary Research Institute, Hudcova 70, Brno 62100, Czech Republic., Procházková J; Department of Pharmacology and Toxicology, Veterinary Research Institute, Hudcova 70, Brno 62100, Czech Republic; Department of Cytokinetics, Institute of Biophysics of the Czech Academy of Sciences, Kralovopolska 135, Brno 61200, Czech Republic., Straková N; Department of Pharmacology and Toxicology, Veterinary Research Institute, Hudcova 70, Brno 62100, Czech Republic., Pěnčíková K; Department of Pharmacology and Toxicology, Veterinary Research Institute, Hudcova 70, Brno 62100, Czech Republic., Strapáčová S; Department of Pharmacology and Toxicology, Veterinary Research Institute, Hudcova 70, Brno 62100, Czech Republic., Slováčková J; Department of Pharmacology and Toxicology, Veterinary Research Institute, Hudcova 70, Brno 62100, Czech Republic; Department of Histology and Embryology, Masaryk University, Kamenice 3, Brno 62500, Czech Republic., Kajabová S; Department of Pharmacology and Toxicology, Veterinary Research Institute, Hudcova 70, Brno 62100, Czech Republic; Department of Experimental Biology, Faculty of Science, Masaryk University, Kamenice 5, 625 00 Brno, Czech Republic., Líbalová H; Department of Genetic Toxicology and Epigenetics, Institute of Experimental Medicine of the Czech Academy of Sciences, Videnska 1083, Prague 142 20, Czech Republic., Topinka J; Department of Genetic Toxicology and Epigenetics, Institute of Experimental Medicine of the Czech Academy of Sciences, Videnska 1083, Prague 142 20, Czech Republic., Kabátková M; Department of Cytokinetics, Institute of Biophysics of the Czech Academy of Sciences, Kralovopolska 135, Brno 61200, Czech Republic., Vondráček J; Department of Cytokinetics, Institute of Biophysics of the Czech Academy of Sciences, Kralovopolska 135, Brno 61200, Czech Republic., Mollerup S; Research Group for Occupational Toxicology, The National Institute of Occupational Health in Norway, Oslo 0304, Norway., Machala M; Department of Pharmacology and Toxicology, Veterinary Research Institute, Hudcova 70, Brno 62100, Czech Republic. Electronic address: miroslav.machala@vri.cz.

Publikováno v: Environmental toxicology and pharmacology [Environ Toxicol Pharmacol] 2024 Apr; Vol. 107, pp. 104424. Date of Electronic Publication: 2024 Mar 22.

Predicted occurrence of ancient coppice woodlands in the Czech Republic

Autor: Madera P, Machala M, Slach T, Friedl M, Cernušáková L, Volarík D, Buček A

Publikováno v: iForest - Biogeosciences and Forestry, Vol 10, Iss 1, Pp 788-795 (2017)

Coppicing started in the Neolithic period and has been practiced throughout European history. This traditional silvicultural system was abandoned in many European countries during the 20th century. The Czech Republic now has a very low proportion of

Externí odkaz: https://doaj.org/article/9bba27e3a23c4d42885bd1a99a5f3f4d

Carcinogenicity of perfluorooctanoic acid and perfluorooctanesulfonic acid.

Autor: Zahm S; International Agency for Research on Cancer, Lyon, France., Bonde JP; International Agency for Research on Cancer, Lyon, France., Chiu WA; International Agency for Research on Cancer, Lyon, France., Hoppin J; International Agency for Research on Cancer, Lyon, France., Kanno J; International Agency for Research on Cancer, Lyon, France., Abdallah M; International Agency for Research on Cancer, Lyon, France., Blystone CR; International Agency for Research on Cancer, Lyon, France., Calkins MM; International Agency for Research on Cancer, Lyon, France., Dong GH; International Agency for Research on Cancer, Lyon, France., Dorman DC; International Agency for Research on Cancer, Lyon, France., Fry R; International Agency for Research on Cancer, Lyon, France., Guo H; International Agency for Research on Cancer, Lyon, France., Haug LS; International Agency for Research on Cancer, Lyon, France., Hofmann JN; International Agency for Research on Cancer, Lyon, France., Iwasaki M; International Agency for Research on Cancer, Lyon, France., Machala M; International Agency for Research on Cancer, Lyon, France., Mancini FR; International Agency for Research on Cancer, Lyon, France., Maria-Engler SS; International Agency for Research on Cancer, Lyon, France., Møller P; International Agency for Research on Cancer, Lyon, France., Ng JC; International Agency for Research on Cancer, Lyon, France., Pallardy M; International Agency for Research on Cancer, Lyon, France., Post GB; International Agency for Research on Cancer, Lyon, France., Salihovic S; International Agency for Research on Cancer, Lyon, France., Schlezinger J; International Agency for Research on Cancer, Lyon, France., Soshilov A; International Agency for Research on Cancer, Lyon, France., Steenland K; International Agency for Research on Cancer, Lyon, France., Steffensen IL; International Agency for Research on Cancer, Lyon, France., Tryndyak V; International Agency for Research on Cancer, Lyon, France., White A; International Agency for Research on Cancer, Lyon, France., Woskie S; International Agency for Research on Cancer, Lyon, France., Fletcher T; International Agency for Research on Cancer, Lyon, France., Ahmadi A; International Agency for Research on Cancer, Lyon, France., Ahmadi N; International Agency for Research on Cancer, Lyon, France., Benbrahim-Tallaa L; International Agency for Research on Cancer, Lyon, France., Bijoux W; International Agency for Research on Cancer, Lyon, France., Chittiboyina S; International Agency for Research on Cancer, Lyon, France., de Conti A; International Agency for Research on Cancer, Lyon, France., Facchin C; International Agency for Research on Cancer, Lyon, France., Madia F; International Agency for Research on Cancer, Lyon, France., Mattock H; International Agency for Research on Cancer, Lyon, France., Merdas M; International Agency for Research on Cancer, Lyon, France., Pasqual E; International Agency for Research on Cancer, Lyon, France., Suonio E; International Agency for Research on Cancer, Lyon, France., Viegas S; International Agency for Research on Cancer, Lyon, France., Zupunski L; International Agency for Research on Cancer, Lyon, France., Wedekind R; International Agency for Research on Cancer, Lyon, France., Schubauer-Berigan MK; International Agency for Research on Cancer, Lyon, France.

Publikováno v: The Lancet. Oncology [Lancet Oncol] 2024 Jan; Vol. 25 (1), pp. 16-17. Date of Electronic Publication: 2023 Nov 30.